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Production of Biologicals by Plant Cell Cultures

  • Donald K. Dougall
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 118)

Abstract

The inclusion of a chapter on the production of biologicals by plant cell cultures in this volume is both appropriate and timely. The topic is timely because the production of a biological by plant cell cultures on commercial scale may be operational within five years. The primary purpose of this chapter is to review the current state of knowledge of plant cell culture as it bears on the production of biologicals.

Keywords

Suspension Culture Callus Culture Plant Tissue Culture Rosmarinic Acid Plant Cell Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Akasu, M., H. Itokawa, and M. Fujita. 1976. Biscoclaurine alkaloids in callus tissues of Stephania cepharantha. Phyto-chemistry (Oxf.) 15:471–473.CrossRefGoogle Scholar
  2. 2.
    Alfermann, A.W., D. Merz and E. Reinhard. 1975. Induction of anthocyanin biosynthesis in tissue cultures of Daucus carota. Planta Medica. Suppl. 70–78.Google Scholar
  3. 3.
    Alfermann, A.W., H.M. Boy, P.C. Döller, W. Hagedorn, M. Heins, J. Wahl, and E. Reinhard. 1977. Biotransformation of cardiac glycosides by plant cell cultures. Pgs. 125–141 in W. Barz, E. Reinhard, and M.H. Zenk, eds. Plant tissue culture and its biotechnological application. Springer-Verlag, Berlin. Springer-Verlag, Berlin.CrossRefGoogle Scholar
  4. 4.
    Bauch, H.J. and E. Leistner. 1978. Aromatic metabolites in cell suspension cultures of Galium mollugo L. Planta Medica 33:105–123.CrossRefGoogle Scholar
  5. 5.
    Bergmann, K. 1960. Growth and division of single cells of higher plants in vitro. J. Gen. Physiol. 43(4):841–851.PubMedCrossRefGoogle Scholar
  6. 6.
    Butcher, D.N. 1977. Secondary products in tissue cultures. Pgs. 668–693 in J. Reinert and Y.P.S. Bajaj, eds. Plant, cell, tissue, and organ culture. Springer-Verlag, Berlin, New York.Google Scholar
  7. 7.
    Butcher, D.N., and J.D. Connolly. 1971. An investigation of factors which influence the production of abnormal terpenoids by callus cultures of Andrographis paniculata Nees. J. Exp. Bot. 22:314–322.CrossRefGoogle Scholar
  8. 8.
    Constabel, F., O.L. Gamborg, W.G.W. Kurz and W. Steck. 1974. Production of secondary metabolites in plant cell cultures. Planta Med. 25:158–165.PubMedCrossRefGoogle Scholar
  9. 9.
    Döller, G. 1978. Influence of the medium on the production of serpentine by suspension cultures of Catharanthus roseus (1.) G. Don. Pgs. 109–129 in. A.W. Alfermann and E. Reinhard, eds. Production of natural compounds by cell culture methods. Proceedings of an international symposium on plant cell culture. BPT-Bericht.Google Scholar
  10. 10.
    Döller, Von G., A.W. Alfermann, and E. Reinhard. 1976. Produc-tion of indole alkaloids in tissue cultures of Catharanthusroseus. Planta Medica 30: 14–20.PubMedCrossRefGoogle Scholar
  11. 11.
    Dougall, D.K., G. Whitten and K.W. Weyrauch. Unpublished.Google Scholar
  12. 12.
    Dougall, D.K. 1979. Factors affecting the yields of secondary products in plant tissue cultures. Proceedings of the Fourth Annual College of Biological Sciences Colloquium: Plant Cell and Tissue Culture — Principles and Applications. Ohio State university Press. (in press).Google Scholar
  13. 13.
    Dougall, D.K. 1979. Preservation of germ plasm. University of Tennessee Symposium. “Propagation of Higher Plants Through Tissue Culture: A Bridge Between Applications and Research.” (proceedings in press).Google Scholar
  14. 14.
    Dougall, D.K. 1979. Storage of Plant Cell Lines. In E John Staba, ed. Plant Tissue Culture as a Source of Biochemicals. CRC Press, Inc., Cleveland (in press).Google Scholar
  15. 15.
    Efstratiadis, A., J.N. Vournakis, H. Donis-Keller, G. Chaconas, D.K Dougall, and F. Kafatos. 1977. End labeling of enzymatical-ly decapped mRNA. Nucleic acids research. 4.(12):4165–4174.PubMedCrossRefGoogle Scholar
  16. 16.
    Farnsworth, N.R. and A.S. Bingel. 1976. Problems and prospects of discovering new drugs from higher plants by pharmacological screening. Pgs. 1–22 in H. Wagner and P. Wolff, eds. New natural products and plant drugs with pharmacological, biological or therapeutical activity. Springer-Verlag. Berlin, Heidelberg, NY.Google Scholar
  17. 17.
    Fowler, M.W. 1977. Growth of cell cultures under chemostat conditions. Pgs. 253–265 in W. Barz, E. Reinhard, and M.H. Zenk, eds. Plant Tissue Culture and Its Bio-technological Application. Springer-Verlag, Berlin.CrossRefGoogle Scholar
  18. 18.
    Furuya, T., H. Kojima and K. Syōno. 1971. Regulation of nicotine biosynthesis by auxins in tobacco cellus tissues. Phytochem. 10:1529–1532.CrossRefGoogle Scholar
  19. 19.
    Gamborg, O.L., T. Murashige, T.A. Thorpe, and I.K. Vasil. 1976. Plant tissue culture media. In Vitro 12:473–477.PubMedCrossRefGoogle Scholar
  20. 20.
    Gibbs, J.L. and D.K. Dougall. 1965. The growth of single cells from Nicotiana tabacum callus tissue in nutrient medium containing agar. Exp. Cell Res. 40:85–95.PubMedCrossRefGoogle Scholar
  21. 21.
    Goldstein, W.E., L.L. Lasure and M.B. Ingle. 1979. Product cost analysis, in E. John Staba, ed. Plant Tissue Culture as a Source of Biochemicals. CRC Press, Inc., Cleveland, OH (in press).Google Scholar
  22. 22.
    Heins, M. 1978. Screening of Digitalis lanata plants and cell cultures for hydroxlation capacity. Pgs. 39–47 in. A.W. Alfermann and E. Reinhard eds. Production of natural compounds by cell culture methods. Proceedings of an international symposium on plant cell culture. BPT-Bericht.Google Scholar
  23. 23.
    Hiraoka, N., and M. Tabata. 1974. Alkaloid production by plants regenerated from cultured cells of Datura innoxia. Phytochemistry (Oxf.) 13:1671–1675.CrossRefGoogle Scholar
  24. 24.
    Hirotani, M., and T. Furuya. 1977. Restoration of cardenolide synthesis in redifferentiated shoots from callus cultures of Digitalis purpurea. Phytochemistry (Oxf.) 16:610–611.CrossRefGoogle Scholar
  25. 25.
    Ikeda, T., T. Matsumoto, and M. Noguchi. 1975. Formation of ubiquinone by tobacco plant cells in suspension culture. Phytochemistry (Oxf.) 15:568–569.CrossRefGoogle Scholar
  26. 26.
    Ikeda, T., T. Matsumoto, and M. Noguchi. 1976. Effects of nutritional factors on the formation of ubiquinone by tobacco plant cells in suspension culture. Agri. Biol. Chem. 40:1765–1770.CrossRefGoogle Scholar
  27. 27.
    Ikuta, A., K. Syōno and T. Furuya. 1974. Alkaloids of callus tissue and redifferentiated plantlets in Papaveraceae. Phytochemistry (Oxf.) 13:2175–2179.CrossRefGoogle Scholar
  28. 28.
    Ikuta, A., K. Syōno, and T. Furuya. 1975. Alkaloids in plants regenerated from Coptis callus cultures. Phytochemistry (Oxf.) 14: 1209–1210.CrossRefGoogle Scholar
  29. 29.
    Jain, S.C., H. Rosenberg and S.J. Stohs. 1977. Steroidal constituents of Trigone11a occulta tissue cultures. Planta Med. 31:109–111.PubMedCrossRefGoogle Scholar
  30. 30.
    Jhang, J.J., E.J. Staba, and J.Y. Kim. 1974. American and Korean ginseng tissue cultures: growth, chemical analysis, and plantlet production. In Vitro 9: 253–259.CrossRefGoogle Scholar
  31. 31.
    Kamimura, S., M. Akutsu, and M. Nishikawa. 1976. Formation of thebaine in the suspension culture of Papaver bracteatum. Agric. Biol. Chem. 40:913–919.CrossRefGoogle Scholar
  32. 32.
    Kao, K.N. and M.R. Michayluk. 1975. Nutritional requirements for growth of Vicia hajastana cells and protoplasts at very low population density in liquid media. Planta (Berl.) 126:105–110.CrossRefGoogle Scholar
  33. 33.
    Kato, A., Y. Shimizu, and S. Nagai. 1975. Effect of initial KLa on the growth of tobacco cells in batch culture. J. Ferment. Techol. 58:744–751.Google Scholar
  34. 34.
    Kato, K., Y. Shiozawa, A. Yamada, K. Nishida, and M. Noguchi. 1972. A jar fermentor culture of Nicotiana tabacum L. cell suspensions. Agric. Biol. Chem. 36:899–902.CrossRefGoogle Scholar
  35. 35.
    Kato, K., T. Matsumoto, A. Koiwai, S. Mizusaki, K. Nishida, M. Noguchi, and E. Tamaki. 1972. Liquid suspension culture of tobacco cells. Proc. IV IFS: Ferment. Technol. Today 1972:689–695.Google Scholar
  36. 36.
    Kaul. B., S.J. Stohs, and E.J. Staba. 1969. Dioscorea tissue cultures. III. Influence of various factors on diosgenin production by Dioscorea deltoidea callus and suspension cultures. Lloydia 32:347–359.PubMedGoogle Scholar
  37. 37.
    Khanna, P., A. Uddin, and M. Sogani. 1976. Pseudoephedrine from in vivo and in vitro tissue cultures of Ephedra foliata Boiss. Indian J. Pharm. 38:140–141.Google Scholar
  38. 38.
    King, P.J., and H.E. Street. 1973. Growth patterns in cell cultures. Pgs. 269–337 in H.E. Street, ed. Plant Tissue and Cell Culture. (Botanical Monographs, Vol. 11.) University of California Press, Berkeley and Los Angeles.Google Scholar
  39. 39.
    Krikorian, A.D., and F.C. Steward. 1969. Biochemical differentiation: The biosynthetic potentialities of growing and quiescent tissue. Pgs. 227–326 in F.C. Steward, ed. Plant Physiology, A Treatise. Vol. VB. Academic Press, New York.Google Scholar
  40. 40.
    Mandels, M. 1972. The culture of plant cells. Pgs. 201–215 in T.K. Ghose, A. Fiechter, and N. Blakebrough, eds. Advances in Biochemical Engineering 2. Springer-Verlag, Berlin.Google Scholar
  41. 41.
    Misawa, M., H. Tanaka, O. Chiyo, and N. Mukai. 1975. Production of a plasmin inhibitory substance by Scopolia japonica suspension cultures. Biotechol. Bioeng. 17:305–314. !CrossRefGoogle Scholar
  42. 42.
    Mizukami, H., M. Konoshima, and M. Tabata. 1978. Variation in pigment production in Lithospermum erythrorhizon callus cultures. Phytochemistry (Oxf.) 17:95–97.CrossRefGoogle Scholar
  43. 43.
    Muir, W.H., A.C. Hildebrant and A.J. Riker. 1958. The preparation, isolation and growth in culture of single cells from higher plants. Am. J. Bot. 45:589–597.CrossRefGoogle Scholar
  44. 44.
    Noguchi, M., T. Matsumoto, Y. Hirata, K. Yamamoto, A. Katsuyama, A. Kato, S. Azechi, and K. Kato. 1977. Improvement of growth rates of plant cell cultures. Pgs. 85–94 in W. Barz, E. Reinhard, and M.H. Zenk, eds. Plant tissue culture and its bio-technological application. Springer-Verlag, Berlin, NY.Google Scholar
  45. 45.
    Ogino, T., N. Hiraoka and M. Tabata. 1978. Selection of high nicotine-producing cell lines of tobacco callus by single-cell cloning. Phytochem. 17:1907–1910.CrossRefGoogle Scholar
  46. 46.
    Ohta, S., O. Matsui and M. Yatazawa. 1978. Culture conditions for nicotine production in tobacco tissue culture. Agri. Biol. Chem. 42:1245–1251.CrossRefGoogle Scholar
  47. 47.
    Puhan, Z. and S.M. Martin. 1971. The industrial potential of plant cell culture. Prog. Ind. Microbio. 9:13–39.Google Scholar
  48. 48.
    Razzaque, A. andB.E. Ellis. 1977. Rosmarinic acid production in Coleus cell cultures. Planta 137:287–291.CrossRefGoogle Scholar
  49. 49.
    Reinhard, E., M. Heins, U. Helmbold, and J. Wahl. 1978. Production of ß-Methyldigoxin by cell cultures of Digitalis Ianata. Pg. 79 in Abstracts. Fourth international congress of plant tissue and cell culture. Calgary, Alberta Canada.Google Scholar
  50. 50.
    Roller, U. 1978. Selection of plants and plant tissue cultures of Catharanthus roseus with high content of serpentine and ajmalicine. Pgs. 95–108 in A.W. Alfermann and E. Reinhard, eds. Production of natural compounds by cell culture methods.Google Scholar
  51. 51.
    Routien, J.B., and Nickell, L.G. 1956. Cultivation of plant tissue. U.S. Patent. 2, 747, 334.Google Scholar
  52. 52.
    Schulte, U. andM.H. Zenk. 1977. A replica plating method for plant cells. Physiol. Plant. 39:139–142.CrossRefGoogle Scholar
  53. 53.
    Staba, E.J. 1977. Tissue culture and pharmacy. Pgs. 694–718 in J. Reinert and Y.P.S. Bajaj, eds. Plant, cell, tissue and organ culture. Springer-Verlag, Berlin, New York.Google Scholar
  54. 54.
    Steck, W., B.K. Bailey, J.P. Shyluk, and O.L. Gamborg. 1971 Coumarins and alkaloids from cell cultures of Ruta graveolens. Phytochemistry (Oxf). 10:191–194.CrossRefGoogle Scholar
  55. 55.
    Tabata, M. andN. Hiraoka. 1976. Variation of alkaloid production in Nicotiana rustica callus cultures. Physiol. Plant. 38:19–23.CrossRefGoogle Scholar
  56. 56.
    Tabata, M., H. Mizukami, N. Hiraoka and M. Konoshima. 1974. Pigment formation in callus cultures of Lithospermum erythrorhi-zon. Phytochem. 13:927–932.CrossRefGoogle Scholar
  57. 57.
    Tabata, M., H. Yamamoto, N. Hiraoka and M. Konoshima. 1972. Organization and alkaloid production in tissue cultures of Scopolia parviflora. Phytochemistry (Oxf.) 11:949–955.CrossRefGoogle Scholar
  58. 58.
    Tabata, M., N. Hiraoka, M. Ikenoue, Y. Sano, and M. Konoshima. 1975. The production of anthraquinones in callus cultures of Cassia tora. Lloydia 38:131–134.PubMedGoogle Scholar
  59. 59.
    Tabata, M., H. Yamamoto, N. Hiraoka, Y. Marumoto, and M. Konoshima. 1971. Regulation of nicotine production in tobacco tissue culture by plant growth regulators. Phytochemistry (Oxf.) 10:723–729.CrossRefGoogle Scholar
  60. 60.
    Tanaka, H., Y. Machida, H. Tanaka, N. Mukai, and M. Misawa. 1974. Accumulation of glutamine by suspension cultures of Symphytum officinale. Agric. Biol. Chem. 38:987–992.CrossRefGoogle Scholar
  61. 61.
    Tulecke, W., R. Taggart, and L. Colavito. 1965. Continuous cultures of higher plant cells in liquid media. Contrib. Boyce Thompson Inst. 23:33–46.Google Scholar
  62. 62.
    Tyler, V.E., L.R. Brady and J.E. Robbers. 1976. Pharmacognosy. 7th edition Lea and Febiger. Philadelphia.Google Scholar
  63. 63.
    Wahl, J. 1978. Biotransformation of ß-Methyldigitoxin by Digitalis lanata fermentor cultures. Pgs. 48–59 in A.W. Alfermann and E. Reinhard eds. Production of natural compounds by cell culture methods. Proceedings of an international symposium on plant cell culture. PFT-Bericht.Google Scholar
  64. 64.
    Waller, G.R. and E.K. Nowacki. 1978. Alkaloid biology and metabolism in plants. Plenum Press, New York and London.CrossRefGoogle Scholar
  65. 65.
    Westcott, R.J., and G.G. Henshaw. 1976. Phenolic synthesis and phenylalanine ammonia-lyase activity in suspension cultures of Acer pseudoplatanus L. Planta. (Berl.) 131:67–73.CrossRefGoogle Scholar
  66. 66.
    Wilson, G. and P. Marron. 1978. Growth and anthraquinone biosynthesis by Galium mollugo L. cells in batch and chemostat culture. J. Exp. Bot. 29:837–851.CrossRefGoogle Scholar
  67. 67.
    Withers, L.A. 1978. Freeze-preservation of cultured cells and tissues. Pgs. 297–306 in T.A. Thorpe, ed. Frontiers of plant tissue culture 1978. International Association for Plant Tissue Culture. The Bookstore, University of Calgary, Calgary, Alberta Canada.Google Scholar
  68. 68.
    Withers, L.A. and H.E. Street. 1977. The freeze-preservation of plant cell cultures of Digitalis lanata. Pgs. 227–244 in. W. Barz, E. Reinhard and M.H. Zenk, eds. Plant tissue culture and its bio-technological application. Springer-Verlag Berlin Heidelberg, New York.Google Scholar
  69. 69.
    Zenk, M.H. 1978. The impact of plant cell culture on industry. Pgs. 1–13 in T.A. Thorpe ed. Frontiers of plant tissue culture 1978. pubs. International Association for Plant Tissue Culture. The Bookstore, University of Calgary, Calgary, Alberta, Canada.Google Scholar
  70. 70.
    Zenk, M.H., El-Shagi and U. Schulte. 1975. Anthaquinone production by cell cultures of Morinda citrifolia. Planta Medica Suppl. 79-101.Google Scholar
  71. 71.
    Zenk, M.H., H. El-Shagi, and B. Ulbrich. 1977. Production of rosmarinic acid by cell-suspension cultures of Coleus blumei. Naturwissenschaften 64:585.CrossRefGoogle Scholar
  72. 72.
    Zenk, M.H., H. El-Shagi, H. Arens, J. Stöckigt, E.W. Weiler, and B. Deus. 1977. Formation of the indole alkaloids serpentine and ajmalicine in cell suspension cultures of Catharanthus roseus. Pgs. 27–43 in W. Barz, E. Reinhard, and M.H. Zenk, eds. Plant tissue culture and its bio-technological applications. Springer-Verlag, Berlin, Heidelberg, New York.CrossRefGoogle Scholar
  73. 73.
    Kato, A.P., S. Kawazoe, M. Iijima and Y. Shimizu. 1976. Continuous culture of tobacco cells. J. Ferment. Technol. 54; 82–87.Google Scholar
  74. 74.
    Wagner, F. and H. Vogelmann. 1977. Cultivation of plant tissue cultures in bioreactors and formation of secondary metabolites. Pgs. 245–252 in W. Barz, E. Reinhard, and M.H. Zenk, eds. Plant Tissue culture and its bio-technological applications. Springer-Verlag, Berlin.CrossRefGoogle Scholar
  75. 75.
    Veliky, I.A. 1977. Effect of pH on tryptophol formation by cultured Ipomoea sp. plant cells. Lloydia 40:482–486.Google Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Donald K. Dougall
    • 1
  1. 1.W. Alton Jones Cell Science CenterLake PlacidUSA

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