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Cellular, Molecular, and Clinical Aspects of Allergic Disorders pp 291–320Cite as

Urticaria and Angioedema

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Part of the book series: Comprehensive Immunology ((COMIMUN,volume 6))

Abstract

Urticaria and angioedema are common disorders affecting approximately 15-20% of the population at least once during their lifetime (Swinny, 1941; Sheldon et al., 1954; McKee, 1966). Urticarial lesions result from localized dilatation and transudation of fluid from small venules, and in their simplest form are thought to represent the same sort of wheal-and-flare reaction observed when histamine is injected into the skin. Clinically, one observes the presence of pruritic, erythematous cutaneous wheals that blanch with pressure, reflecting the underlying edema and dilated blood vessels. The histopathological features of urticaria are dilatation of cutaneous blood vessels and lymphatics in the superficial dermis, widening of dermal papillae, flattening of rete pegs, and swelling of collagen fibers.

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  1. Allen P. Kaplan

    Present address: Division of Allergy-Rheumatology, Health Sciences Center, State University of New York, Stony Brook, New York, 11794, USA

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  1. Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    Allen P. Kaplan

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    Sudhir Gupta M.D., F.R.C.P.(C), F.A.C.P.  & Robert A. Good Ph.D., M.D.  & 

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Kaplan, A.P. (1979). Urticaria and Angioedema. In: Gupta, S., Good, R.A. (eds) Cellular, Molecular, and Clinical Aspects of Allergic Disorders. Comprehensive Immunology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0988-8_8

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