Abstract
Material elsewhere in this volume provides ample documentation of the existence of specific receptor molecules for a variety of signal-transmitting molecules acting on cells. The neurotransmitters and the circulating hormones are the most obvious categories of these messengers (although far from the only ones). We shall use the term receptor here to denote such structures in the cell plasma membrane, equipped specifically to recognize primary messenger molecules arriving at their cell and to trigger directly the cellular response to these or to initiate the required signal to other machinery that generates the response (e.g., a separate nucleotide cyclase). In contrast, messenger-binding components in the cell interior which are not concerned with the primary recognition of externally incident messengers, while they may be involved in some cases in mediating the cellular response (e.g., to thyroid or steroid hormones), present an entirely different aspect to the problem of receptor location and will not be considered here. Receptors involved in the immune response, which are a very special case, are also outside the scope of this chapter.
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Barnard, E.A. (1979). Visualization and Counting of Receptors at the Light and Electron Microscope Levels. In: O’Brien, R.D. (eds) General Principles and Procedures. The Receptors, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0979-6_7
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