Abstract
The biological effect of chemical agents can only be the result of an interaction of the molecules of the active agent and particular molecules or molecular complexes present in the biological object. The same holds true for endogenous bioactive agents such as hormones, neurotransmitters, etc. Often these messengers have their molecular sites of action, referred to as their specific receptors, located on the outer cell membrane (Lefkowitz et al., 1976). They then transmit information from remote or nearby cells to the surface of the target cells where they trigger these cells, thus inducing certain changes in cell function. The interaction between the bioactive agent and its specific receptors initiates the transduction of information received from outside to the cell interior. An example is the generation of intracellular mediators such as cyclic AMP. Similarly, the hormone-receptor complex, in the case of the interaction of steroid hormones and their specific proteins in the cytoplasm, is involved in the transduction of information to the cell nucleus. The presence of specific receptor for the bioactive agents either on the outer cell membrane or in the cytoplasm of only particular tissue cells accounts for a selectivity in action on these tissues.
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AriĆ«ns, E.J., Beld, A.J., de Miranda, J.F.R., Simonis, A.M. (1979). The Pharmacon-Receptor-Effector Concept. In: OāBrien, R.D. (eds) General Principles and Procedures. The Receptors, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0979-6_2
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