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Chromatin Structure and Function pp 67–107Cite as

Circular Dichroism of DNA, Proteins and Chromatin

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Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 21a))

Abstract

Although great strides have been made towards the elucidation of the structure of chromatin, many details remain unanswered as to the manner in which DNA is folded and condensed in the nucleus. The role played by the histones in the condensation of DNA in the nucleosome and the higher order tertiary structure still awaits clarification. The state of condensation of DNA plays an important role in genetic regulation as this conformational flexibility determines which regions of the DNA are available for transcription.

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  1. Grad. Dept. Biochemistry, Brandeis University, 415 South St., Waltham, Massachusetts, 02154, USA

    Gerald D. Fasman

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  1. Temple University, Philadelphia, Pennsylvania, USA

    Claudio A. Nicolini

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Fasman, G.D. (1979). Circular Dichroism of DNA, Proteins and Chromatin. In: Nicolini, C.A. (eds) Chromatin Structure and Function. NATO Advanced Study Institutes Series, vol 21a. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0973-4_5

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