Skip to main content
SpringerLink
Log in

Interaction of Insecticides with Acetylcholine Receptors

  • Chapter
Neurotoxicology of Insecticides and Pheromones

  • 69 Accesses

Abstract

The rational design of insecticides depends on the discovery of biochemical differences between target insects and organisms (including man) that should not be affected. This permits the selection of agents that act on a site that is not present in vertebrates, or at least has lower sensitivity to the agent. Our comparative study of vertebrate and insect acetylcholine receptors, which is just beginning, is in part an attempt to identify compounds with selective blocking ability on the acetylcholine receptors of insects.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. Sakai, M. (1969) Rev. Plant Protec. Res. 2, 17.

    Google Scholar 

  2. Farrow, J.T., and O’Brien, R.D. (1973) Molec. Pharmacol. 9, 33.

    CAS  Google Scholar 

  3. Schleifer, L.S., and Eldefrawi, M.E. (1974) Neuropharmacol. 13, 53.

    Article  CAS  Google Scholar 

  4. Salvaterra, P.M., and Mahler, H.R. (1976) J. Biol. Chem. 251, 6327.

    PubMed  CAS  Google Scholar 

  5. Yamamura, H.I., and Snyder, S.H. (1974) Proc. Nat. Acad. Sci. USA 71, 1725.

    Article  PubMed  CAS  Google Scholar 

  6. McCance, I., Phillis, J.W., Tebecis, A.K., and Westerman, R.A. (1968) Br. J. Pharmacol. Chemother. 32, 652.

    PubMed  CAS  Google Scholar 

  7. Bradley, P.B., and Wolstencroft, J.H. (1965) Br. Med. Bull. 21, 15.

    PubMed  CAS  Google Scholar 

  8. Anderson, P., and Curtis, D.R. (1964) Acta Physiol. Scand. 61, 100.

    Article  Google Scholar 

  9. Dudai, Y., and Amsterdam, A. (1977) Brain Res. 130, 551.

    Article  PubMed  CAS  Google Scholar 

  10. Schmidt-Nielsen, B.K., Gepner, J.I., Teng, N.N.H., and Hall, L.M. (1977) J. Neurochem. 29, 1013.

    Article  PubMed  CAS  Google Scholar 

  11. Dudai, Y. (1978) Biochim. Biophys. Acta (in press.).

    Google Scholar 

  12. Sanes, J.R., Prescott, D.J., and Hildebrand, J.G. (1977) Brain Res. 119, 389.

    Article  PubMed  CAS  Google Scholar 

  13. Dudai, Y. (1977) FEBS Lett. 76., 211.

    Article  PubMed  CAS  Google Scholar 

  14. Shain, W., Greene, L.A., Carpenter, D.O., Sytkowski, A.J., and Vogel, Z. (1974) Brain Res. 72, 225.

    Article  PubMed  CAS  Google Scholar 

  15. Dudai, Y., and Ben-Barak, J. (1977) FEBS Lett. 81, 134.

    Article  PubMed  CAS  Google Scholar 

  16. Eldefrawi, A.T., and O’Brien, R.D. (1970) J. Neurochem. 17, 1287.

    Article  PubMed  CAS  Google Scholar 

  17. Eldefrawi, M.E., Eldefrawi, A.T., and O’Brien, R.D. (1971) Molec. Pharmacol. 7, 104.

    CAS  Google Scholar 

  18. Eldefrawi, M.E., Eldefrawi, A.T., and O’Brien, R.D. (1970) J. Agr. Food Chem. 18, 1113.

    Article  CAS  Google Scholar 

  19. Jewess, P.J., Clarke, B.S., and Donnellan, J.F. (1975) Croat. Chem. Acta 47, 459.

    CAS  Google Scholar 

  20. Mansour, N.A., Eldefrawi, M.E., and Eldefrawi, A.T. (1977) Biochemistry 16, 4126.

    Article  PubMed  CAS  Google Scholar 

  21. Donnellan, J.F., Jewess, P.J., and Cattell, K.J. (1975) J. Neurochem. 25, 623.

    Article  PubMed  CAS  Google Scholar 

  22. Tripathi, R.K., and O’Brien, R.D. (1977) Biochem. Biophys. Acta 480, 382.

    PubMed  CAS  Google Scholar 

  23. Clarke, B.S., and Donnellan, J.F. (1975) Biochem. Soc. Trans. 2, 1373.

    Google Scholar 

  24. Yeh, J.Z., Narahashi, T., and Almon, R.R. (1975) J. Pharmacol. Exp. Ther. 194, 373.

    PubMed  CAS  Google Scholar 

  25. Daly, J.W., Karle, I., Myers, C.W., Tokuyama, T., Waters, J.A., and Witkop, B. (1971) Proc. Nat. Acad. Sci. USA 68, 1870.

    Article  PubMed  CAS  Google Scholar 

  26. Mansour, N.A., Eldefrawi, A.T., and Eldefrawi, M.E. (1978) Life Sci. (in press).

    Google Scholar 

  27. Albuquerque, E.X., Eldefrawi, A.T., Eldefrawi, M.E., Mansour, N.A. and Tsai, M.-C. (1978) Science 199, 788.

    Article  PubMed  CAS  Google Scholar 

  28. Eldefrawi, M.E., Britten, A.G., and O’Brien, R.D. (1971) Pestic. Biochem. Physiol. 1, 101.

    Article  CAS  Google Scholar 

  29. Narahashi, T. (1974) Physiol. Rev. 54, 813.

    Article  PubMed  CAS  Google Scholar 

  30. Rollo, I.M. (1975) in “The Pharmacological Basis of Therapeutics”, Goodman, L.S., and Gilman, A.G., Eds., Fifth Edition, Macmillan, New York, pp. 1018–1044.

    Google Scholar 

  31. Hillman, G.R., and Senft, A.W. (1975) Am. J. Trop. Med. Hyg. 24, 827.

    PubMed  CAS  Google Scholar 

  32. Norton, S., and de Beer, E.J. (1957) Am. J. Trop. Med. Hyg. 6, 848.

    Google Scholar 

  33. Del Castillo, J., Morales, T.A., and Sanchez, V. (1963) Nature 200, 706.

    Article  CAS  Google Scholar 

  34. Aziz, S.A. and Eldefrawi, M.E. (1973) Pestic. Biochem. Physiol. 3, 168.

    Article  CAS  Google Scholar 

  35. Fertuck, H.C., and Salpeter, M.M. (1976) J. Cell Biol. 69, 144.

    Article  PubMed  CAS  Google Scholar 

  36. Denburg, J.L., Eldefrawi, M.E., and O’Brien, R.D. (1972) Proc. Nat. Acad. Sci. USA 69, 111.

    Article  Google Scholar 

  37. Jones, S.W., Galasso, R.T., and O’Brien, R.D. (1977) J. Neurochem. 29, 803.

    Article  PubMed  CAS  Google Scholar 

  38. Marquis, J.K., Hilt, D.C., and Mautner, H.G. (1977) Biochem. Biophys. Res. Commun. 78, 476.

    Article  PubMed  CAS  Google Scholar 

  39. Greene, L.A., Sytkowski, A.J., Vogel, Z., and Nirenberg, M.W. (1973) Nature 243, 163.

    Article  PubMed  CAS  Google Scholar 

  40. Fumagalli, L., DeRenzis, G., and Miani, N. (1976) J. Neurochem. 27, 47.

    Article  PubMed  CAS  Google Scholar 

  41. Wilson, S.P., and Kirshner, N. (1977) J. Neurochem. 28, 687.

    Article  PubMed  CAS  Google Scholar 

  42. Chou, T.C., and Lee, C.Y. (1969) Eur. J. Pharmacol. 8, 326.

    Article  PubMed  CAS  Google Scholar 

  43. Obata, K. (1974) Brain Res. 73, 71.

    Article  PubMed  CAS  Google Scholar 

  44. Brown, D.A., and Fumagalli, L. (1977) Brain Res. 129, 165.

    Article  PubMed  CAS  Google Scholar 

  45. Bursztajn, S., and Gershon, M.D. (1977) J. Physiol. 269, 17.

    PubMed  CAS  Google Scholar 

  46. Patrick, J. and Stallcup, B. (1977) J. Biol. Chem. 252, 8629.

    PubMed  CAS  Google Scholar 

  47. Carbonetto, S., Fambrough, D.M., and Müller, K.J. (1977) Neurosci. Abstracts 3, 454.

    Google Scholar 

  48. Colquhoun, D., and Rang, H.P. (1976) Molec. Pharmacol. 12, 519.

    CAS  Google Scholar 

  49. Kehoe, J.S. (1972) J. Physiol. 225 115.

    PubMed  CAS  Google Scholar 

  50. Kehoe, J.S., Sealock, R., and Bon, C. (1976) Brain Res. 107, 527.

    Article  PubMed  CAS  Google Scholar 

  51. Kehoe, J.S., and Marder, E. (1976) Ann. Rev. Pharmacol. Toxicol. 16, 245.

    Article  CAS  Google Scholar 

  52. Luduena, F.P., and Brown, T.G. (1952) J. Pharmacol. Exp. Ther. 105, 232.

    PubMed  CAS  Google Scholar 

  53. Florey, E. (1967) Comp. Biochem. Physiol. 20, 365.

    Article  PubMed  CAS  Google Scholar 

  54. Shankland, D.L., Rose, J.A., Donniger, C. (1971) J. Neurobio. 2, 247.

    Article  CAS  Google Scholar 

  55. Sattelle, D.B., McClay, A.S., Dowson R.J., and Callec, J.J. (1976) J. Exp. Biol. 64, 13.

    PubMed  CAS  Google Scholar 

  56. Twarog, B.M. (1954) J. Cell. Comp. Physiol. 44, 141.

    Article  CAS  Google Scholar 

  57. Cambridge, C.W., Holgate, J.A., Sharp, J.A. (1959) J. Physiol. 148, 451.

    PubMed  CAS  Google Scholar 

  58. Marder, E. (1976) J. Physiol. 257, 63.

    PubMed  CAS  Google Scholar 

  59. Carlson, A.J. (1907) Am. J. Physiol. 17, 177.

    Google Scholar 

  60. Naidu, M.B. (1955) Bull. Ent. Res. 6, 205.

    Article  Google Scholar 

  61. Eldefrawi, M.E., Eldefrawi, A.T., Seifert, S., and O’Brien, R.D. (1972) Arch. Biochem. Biophys. 150, 210.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Neurobiology and Behavior, Cornell University, Ithaca, New York, 14853, USA

    S. W. Jones, P. Sudershan & R. D. O’Brien

Authors
  1. S. W. Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Sudershan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. D. O’Brien
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, Medical School, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois, 60611, USA

    Toshio Narahashi

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Plenum Press, New York

About this chapter

Cite this chapter

Jones, S.W., Sudershan, P., O’Brien, R.D. (1979). Interaction of Insecticides with Acetylcholine Receptors. In: Narahashi, T. (eds) Neurotoxicology of Insecticides and Pheromones. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0970-3_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-0970-3_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0972-7

  • Online ISBN: 978-1-4684-0970-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation