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Drug Effects on Platelet Adherence to Collagen and Damaged Vessel Walls

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Book cover Drugs, Lipid Metabolism, and Atherosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 109))

Abstract

The interaction of platelets with damaged vessel walls leads to the formation of platelet-fibrin thrombi and may also contribute to the development of atherosclerotic lesions because platelets adherent to exposed collagen release a mitogen that stimulates smooth muscle cell proliferation. The first step in thrombus formation, platelet adherence to an injured vessel wall, can be studied quantitatively by the use of platelets labeled with 51chromium. In these investigations, rabbit aortas were damaged by passage of a balloon catheter and segments of the aortas were everted on probes that were rotated in platelet suspensions. Collagen-coated glass cylinders were also used. Adherence was measured in a medium containing approximately physiologic concentrations of calcium, magnesium, protein and red blood cells. Conditions of testing influence the effect of non-steroidal anti-inflammatory drugs, sulfinpyrazone, and dipyridamole on platelet adherence. Aspirin and sulfinpyrazone were not inhibitory when tested in a medium with a 40% hematocrit; this indicates that products formed by platelets from arachidonate probably do not play a major part in the adherence of the first layer of platelets to the surface, although they may be involved in thrombus formation.

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References

  1. Mustard, J.F. and Packham, M.A. Thromb. Diath. Haemorrh.33 444 (1975)

    PubMed  CAS  Google Scholar 

  2. Mustard, J.F., Moore, S., Packham, M.A. and Kinlough- Rathbone, R.L. In: Proceedings of the First International Atherosclerosis Conference," Prog. Biochem. Pharmacol., Karger, Basel (in press).

    Google Scholar 

  3. Ross, R., Glomset, J. and Harker, L.A. Am. J. Pathol. 86: 675 (1977)

    CAS  Google Scholar 

  4. Davignon, J. In: Hypertension: Physiopathology and Treatment J. Genest, E. Koiw and O. Kuchel, editors, McGraw- Hill, 1977, in press.

    Google Scholar 

  5. Ross, R. and Glomset, J.A. New Engl. J. Med. 7:369 (1976)

    Article  Google Scholar 

  6. HoImsen, H. In: Biochemistry and Pharmacology of Platelets, Ciba Foundation Symposium 3 5, Elsevier, New York, 1975, p. 175

    Google Scholar 

  7. Chesney, C.M., Harper, E. and Colman, R.W. J. Clin. Invest. 53 1647 (1974)

    Article  PubMed  CAS  Google Scholar 

  8. Legrand, Y., Pignaud, G. and Caen, J.P. Haemostasis 6: 180 (1977)

    PubMed  CAS  Google Scholar 

  9. Packham, M.A., Nishizawa, E.E. and Mustard, J.F. Biochem. Pharmacol. (Suppl.): 171 (1968)

    Google Scholar 

  10. Nachman, R.L., Weksler, B. and Ferris, B. J. Clin. Invest. 51 549 (1972)

    Article  CAS  Google Scholar 

  11. Moncada, S., Ferreira, S.H. and Vane, J.R. Nature 246: 217 (1973)

    Article  PubMed  CAS  Google Scholar 

  12. Kuehl, F.A., Jr., Humes, J.L., Egan, R.W., Ham, E.A., Beveridge, G.C. and van Arman, C.G. Nature 265: 170 (1977)

    Article  PubMed  CAS  Google Scholar 

  13. Bunting, S., Gryglewski, R., Moncada, S. and Vane, J.R. Prostaglandins 12:897 (1976)

    Article  PubMed  CAS  Google Scholar 

  14. Svensson, J. and Hamberg, M. Prostaglandins 12: 943 (1976)

    Article  PubMed  CAS  Google Scholar 

  15. Needleman, P., Kulkarni, P.S. and Raz, A. Science 195: 409 (1977)

    Article  PubMed  CAS  Google Scholar 

  16. Ross, R., Glomset, J., Kariya, B. And” Harker, L. Proc. Natl. Acad. Sci. USA 71: 1207 (1974)

    Article  CAS  Google Scholar 

  17. Moore, S., Friedman, R.J., Singal, D.P. Gauldie, J., Blajchman, M.A. and Roberts, R.S. Thrombos. Haemostasis 35 70 (1976)

    CAS  Google Scholar 

  18. Friedman, R.J., Stemerman, M.B., Wenz, B., Moore, S., Gauldie, J., Gent, M., Tiell, M.L. and Spaet, T.H. J. Clin. Invest., in press

    Google Scholar 

  19. Baumgartner, H.R., Muggli, R., Tschopp, T.B. and Turitto, V.T. Thrombos. Haemostasis 35 124 (1976)

    CAS  Google Scholar 

  20. Smith, J.B., Ingerman, C., Kocsis, J.J. and Silver, M.J. J. Clin. Invest. 53: 1468 (1974)

    Article  PubMed  CAS  Google Scholar 

  21. Willis, A.L., Vane, F.M., Kuhn, D.C., Scott, C.G. and Petrin, M. Prostaglandins 8: 453 (1974)

    Article  PubMed  CAS  Google Scholar 

  22. Hamberg, M. and Samuelsson, B. Proc. Natl. Acad. Sci. USA 71:400 (1974)

    Google Scholar 

  23. Hamberg, M., Svensson, J. and Samuelsson, B. Proc. Natl. Acad. Sci. USA 72: 2994 (1975)

    Article  PubMed  CAS  Google Scholar 

  24. Niewiarowski, S., Stuart, R.K. and Thomas, D.P. Proc. Soc. Exp. Biol. Med. 123: 196 (1966)

    PubMed  CAS  Google Scholar 

  25. Walsh, P.N. Br. J. Haematol. 22: 237 (1972)

    Article  PubMed  CAS  Google Scholar 

  26. Schiffman, S., Rimon, A. and Rapaport, S.I. Br. J. Haematol. 35: 429 (1977)

    Article  PubMed  CAS  Google Scholar 

  27. Joist, J.H., Dolezel, G., Lloyd, J.V., Kinlough- Rathbone, R.L. and Mustard, J.F. J. Lab. Clin. Med. 84: 474 (1974

    CAS  Google Scholar 

  28. Mustard, J.F. and Packham, M.A. In: Inflammation, Immunity and Hypersensitivity, H.Z. Movat, editor. Harper and Row, New York, 1971, p. 528

    Google Scholar 

  29. Walsh, P.N. Blood 43 597 (1974)

    Google Scholar 

  30. Nemerson, Y. and Pitlick, F.A. In: Progress in Hemostasis and Thrombosis, T.H. Spaet, editor. Vol. 1, Grune and Stratton, New York, 1972, p. 1

    Google Scholar 

  31. Bills, T.K. Smith, J.B. and Silver, M. J. J. Clin. Invest. 60: 1 (1977)

    Article  CAS  Google Scholar 

  32. Packham, M.A., Kinlough-Rathbone, R.L., Reimer H.-J., Scott, S. and Mustard, J.F. In: Prostaglandins in Hematology, M.J. Silver, J.B. Smith, J.J. Kocsis, editors. Spectrum Publications, New York, 1977, p. 247

    Google Scholar 

  33. Kinlough-Rathbone, R.L., Packham, M.A., Reimers, H.J., Cazenave, J.-P. and Mustard, J.F. J. Lab. Clin. Med., in press

    Google Scholar 

  34. Niewiarowski, S., Regoeczi, E., Stewart, G.J., Senyi, A. and Mustard, J.F. J. Clin. Invest. 51 685 (1972)

    Article  PubMed  CAS  Google Scholar 

  35. Weksler, B.B. and Coupal, C.E. J. Exp. Med. 137: 1419 (1973)

    Article  PubMed  CAS  Google Scholar 

  36. Turner, S.R., Tainer, J.A. and Lynn, W.S. Nature 257: 680 (1975)

    Article  PubMed  CAS  Google Scholar 

  37. Dalldorf, F.G., Pate, D.H. and Langdell, R.D. Arch. Pathol. 85: 149 (1968)

    PubMed  CAS  Google Scholar 

  38. Burch, G.E. Am. Heart J. 87: 407 (1974)

    Article  PubMed  CAS  Google Scholar 

  39. Hardin, N.J., Minick, C.R. and Murphy, G.E. Am. J. Pathol. 73: 301 (1973)

    PubMed  CAS  Google Scholar 

  40. Lough, J. and Moore, S. Lab. invest. 33: 130 (1975)

    PubMed  CAS  Google Scholar 

  41. Harker, L.A., Ross, R., Slichter, S.J. and Scott, C.R. J. Clin. Invest. 58 731 (1976)

    CAS  Google Scholar 

  42. Ross, R. and Harker, L. Science 193: 1094 (1976)

    Article  PubMed  CAS  Google Scholar 

  43. Thomsen, H.K. Atherosclerosis 20.:233 (1974)

    Article  Google Scholar 

  44. Ross, R. and Harker, L. Science 193: 1094 (1976)

    Article  PubMed  CAS  Google Scholar 

  45. Fry, D.L. Circ. Res. 22: 165 (1968)

    Article  PubMed  CAS  Google Scholar 

  46. Cazenave, J.-P., Packham, M.A., Davies, J.A., Kinlough-Rathbone, R.L. and Mustard, J.F. In: The Significance of Platelet Function Tests in the Evaluation of Hemostatic and Thrombotic Tendencies Workshop on Platelets, H.J. Day, M.B. Zucker, H. Helmsen, editors, Philadelphia, 1976, in press

    Google Scholar 

  47. Muggli, R. and Baumgartner, H.R. Thromb. Diath. Haemorrh. 34: 333 (1975)

    PubMed  CAS  Google Scholar 

  48. Cazenave, J.-P., Packham, M.A. and Mustard, J.F. J. Lab. Clin. Med. 82: 978 (1973)

    PubMed  CAS  Google Scholar 

  49. Dosne, A.-M., Drouet, L. and Dassin, E. Microvasc. Res. 11: 111 (1976)

    Article  PubMed  CAS  Google Scholar 

  50. Schlossman, D. Acta Radiol. Diag. 14: 97 (1973)

    CAS  Google Scholar 

  51. Lagergren, H., Olsson, P. and Swedenborg, J. Surgery 25: 643 (1974)

    Google Scholar 

  52. Baumgartner, H.R., Stemerman, M.B. and Spaet, T.H. Experentia 27 283 (1971)

    Article  CAS  Google Scholar 

  53. Brass, L.F., Faile, D. and Bensusan, H.B. J. Lab. Clin. Med. 82: 525 (1976)

    Google Scholar 

  54. Cowan, D.H., Robertson, A.L., Jr., Giroski, P. and Shook, P. Abstracts, 6th International Symposium on Drugs Affecting Lipid Metabolism, these proceedings

    Google Scholar 

  55. Lyman, B., Rosenberg, L. and Karpatkin, S. J. Clin. Invest. 50 1854 (1971)

    Article  PubMed  CAS  Google Scholar 

  56. Cazenave, J.-P., Packham, M.A., Guccione, M.A. and Mustard, J.F. J. Lab. Clin. Med. 86 551 (1975)

    PubMed  CAS  Google Scholar 

  57. Goldsmith, H.L. In: Progress in Hemostasis and Thrombosis, T.H. Spaet, editor. Vol. 1, Grune and Stratton,New York, 1972, p. 97

    Google Scholar 

  58. Turitto, V.T. and Baumgartner, H.R. Microvasc. Res. 9: 335 (1975)

    Article  PubMed  CAS  Google Scholar 

  59. Leonard, E.F., Grabowski, E.F. and Turitto, V.T. Ann. N.Y. Acad. Sci. 201: 329 (1972)

    Article  PubMed  CAS  Google Scholar 

  60. Brash, J.L., Brophy, J.M. and Feuerstein, I.A. J. Biomed. Mat. Res. 10: 429 (1976)

    Article  CAS  Google Scholar 

  61. Baumgartner, H.R. and Muggli, R. Thromb. Diath. Haemorrh. Suppl. 60: 345 (1974)

    CAS  Google Scholar 

  62. Davies, J.A., Essien, E., Kinlough-Rathbone, R.L., Cazenave, J.-P. and Mustard, J.F. Blood 46: 1003 (1975)

    Google Scholar 

  63. Cazenave, J.-P., Packham, M.A., Guccione, M.A. and Mustard, J.F. J. Lab. Clin. Med. 83 797 (1974)

    PubMed  CAS  Google Scholar 

  64. Willis, A.L. Science 183 325 (1974)

    Article  PubMed  CAS  Google Scholar 

  65. Roth, G.J. and Majerus, P.W. In: Prostaglandins in Hematology, M.J. Silver, J.B. Smith and J.J. Kocsis, editors. Spectrum Publications, New York, 1977, p. 345

    Google Scholar 

  66. Malmsten, C., Hamberg, M., Svensson, J. and Samuelsson, B. Proc. Natl. Acad. Sci. USA 72 1446 (1975)

    Article  PubMed  CAS  Google Scholar 

  67. Ali, M. and McDonald, J.W.D. J. Lab. Clin. Med. 89 868 (1977)

    PubMed  CAS  Google Scholar 

  68. Danese, C.A., Voleti, C.D. and Weiss, H.J. Thromb. Diath. Haem. 25 288 (1971)

    CAS  Google Scholar 

  69. Mustard, J.F. and Packham, M.A. In: Current Drug Reviews: Cardiology, Vol. 3, Australasia, Adis Press, in press

    Google Scholar 

  70. Mills, D.C.B, and Smith, J.B. Biochem. J. 121: 185 (1971)

    PubMed  CAS  Google Scholar 

  71. Wolfe, S.M. and Shulman, N.R. Biochem. Biophys. Res.Commun. 35 265 (1969)

    Article  PubMed  CAS  Google Scholar 

  72. Haslam, R.J. In: Biochemistry and Pharmacology of Platelets, Ciba Foundation Symposium 3 5, Elsevier, New York, 1975, p. 121

    Google Scholar 

  73. Kinlough-Rathbone, R.L., Packham, M.A. and Mustard, J.F. Brit. J. Haematol, 19: 559 (1970)

    Article  CAS  Google Scholar 

  74. Ferreira, S.H. and Vane, J.R. Nature 216: 868 (1967)

    Article  PubMed  CAS  Google Scholar 

  75. Mannucci, P.M. and Pareti, F.I. J. Lab. Clin. Med. 84: 828 (1974)

    CAS  Google Scholar 

  76. Cazenave, J.-P., Davies, J.A., Senyi, A.F., Blajchman, M.A., Hirsh, J. and Mustard, J.F. Blood 48:1009 (1976)

    Google Scholar 

  77. Hong, S.-C.L. and Levine, L. Proc. Natl. Acad. Sci. USA 73: 1730 (1976)

    Article  PubMed  CAS  Google Scholar 

  78. Cazenave, J.-P., Guccione, M.A., Packham, M.A. and Mustard, J.F. Br. J. Haematol. 35:131 (1977)

    Article  Google Scholar 

  79. Cazenave, J.-P., Packham, M.A., Guccione, M.A. and Mustard, J.F. Proc. Soc. Exptl. Biol. Med. 142: 159 (1973)

    CAS  Google Scholar 

  80. McClure, P.D., Casserly, J.G., Monsier, C. and Crozier, D. Lancet 2: 1307 (1970)

    Article  PubMed  CAS  Google Scholar 

  81. Brown, C.H.,III, Natelson, E.A., Bradshaw, M.W., Alfrey, C.P., Jr. and Williams, T.W., Jr. Antimicrobial Agents and Chemotherapy 7 652 (1975)

    Article  PubMed  CAS  Google Scholar 

  82. Brown, C.H., III, Bradshaw, M.W., Natelson, E.A., Alfrey, C.P., Jr., and Williams, T.W., Jr. Blood 47: 949 (1976)

    PubMed  CAS  Google Scholar 

  83. Packham, M.A., Warrior, E.S., Glynn, M.F., Senyi, A.F. and Mustard, J.F. J. Exp. Med. 126:171 (1967)

    Article  PubMed  CAS  Google Scholar 

  84. Zucker, M.B. and Peterson, J. J.Lab. Clin. Med. 76: 66 (1970)

    PubMed  CAS  Google Scholar 

  85. Evans, G., Packham, M.A., Nishizawa, E.E., Mustard, J.F. and Murphy, E.A. J. Exp. Med. 128: 877 (1968)

    Article  PubMed  CAS  Google Scholar 

  86. Zucker, M.B. Thromb. Diath. Haemorrh. 28: 393 (1972)

    PubMed  CAS  Google Scholar 

  87. Ihnatowycz, I.O., Cazenave, J.-P., Moore, S. and Mustard, J.F. Thrombos. Haemostas. 38 229 (1977)

    Google Scholar 

  88. Kinlough-Rathbone, R.L., Reimers, H.J., Mustard, J.F. and Packham, M.A. Science 192: 1011 (1976)

    Article  PubMed  CAS  Google Scholar 

  89. Baumgartner, H.R. and Studer, A. Workshop on Thrombosis and Atherosclerosis, Tokyo, 1976, personal communication

    Google Scholar 

  90. Clowes, A.W. and Karnovsky, M.J. Lab. invest. 36: 452 (1977)

    PubMed  CAS  Google Scholar 

  91. Ho, P.P.K., Herrmann, R.G., Towner, R.D. and Walters, C.P. Biochem. Biophys. Res. Comm. 74: 514 (1977)

    Article  PubMed  CAS  Google Scholar 

  92. Moncada, S., Herman, A.G., Higgs, E.A. and Vane, J.R. Thromb. Res. 11,: 3 23 (1977)

    Article  Google Scholar 

  93. Gorman, R.R., Bunting, S. and Miller, O.V. Prostaglandins 33: 377 (1977)

    Google Scholar 

  94. Tateson, J.E., Moncada, S. and Vane, J.R. Prostaglandins J3: 389 (1977)

    Google Scholar 

  95. Cazenave, J.-P., Kinlough-Rathbone, R.L., Packham, M.A. and Mustard, J.F., unpublished observations

    Google Scholar 

  96. Baumgartner, H.R., Tschopp, T.B. and Weiss, H.J. Thrombos, Haemostas. 37 17 (1977)

    CAS  Google Scholar 

  97. Ts’ao, C. Am. J. Pathol. 59 327 (1970)

    PubMed  Google Scholar 

  98. Mason, R.G., Sharp, D., Chuang, H.Y.K, and Mohammad, S.F. Archiv. Pathol. Lab. Med. 101: 61 (1977)

    CAS  Google Scholar 

  99. Jenkins, C.S.P. and Packham, M.A., unpublished observations

    Google Scholar 

  100. Essien, E.M., Cazenave, J.-P., Moore, S. and Mustard, J.F., submitted for publication

    Google Scholar 

  101. Aubrey, B.J., Owen, W.G., Fry, G.L., Cheng, F.H. and Hoak, J.C. Blood 46: 1046 (1975)

    Google Scholar 

  102. Clowes, A.W. and Karnovsky, M.J. Nature 265: 625 (1977)

    Article  PubMed  CAS  Google Scholar 

  103. Hornstra, G. Haemostasis 2: 21 (1973–74)

    PubMed  CAS  Google Scholar 

  104. Sim, A.K. and McCraw, A.P. Thrombos. Res. 10: 385 (1977)

    Article  CAS  Google Scholar 

  105. Willis, A.L., Comai, K., Kuhn, D.C. and Paulsrud, J. Prostaglandins 8: 509 (1974)

    Article  PubMed  CAS  Google Scholar 

  106. Oelz, O., Seyberth, H.W., Knapp, H.R. and Gates, J.A. In: Advances in Prostaglandin and Thromboxane Research, B. Samuelsson, R. Paoletti, editors. Vol. 2 Raven,New York, 1976, p. 787

    Google Scholar 

  107. Kernoff, P.B.A., Davies, J.A., McNicol, G.P., Willis, A.L. and Stone, K.J. Thrombos. Haemostas. 194 (1977)

    Google Scholar 

  108. Seyberth, H.W., Oelz, O., Kennedy, T., Sweetman, B.J., Danon, A., Fröhlich, J.C., Heimberg, M. and Gates, J.A. Clin. Pharmacol. Therap. 38: 521 (1975)

    Google Scholar 

  109. Renaud, S., Kinlough, R.L. and Mustard, J.F. Lab. invest. 22: 339 (1970)

    PubMed  CAS  Google Scholar 

  110. Mustard, J.F. and Murphy, E.A. Br. Med. J. 1: 1651 (1962)

    Article  PubMed  CAS  Google Scholar 

  111. lacono, J.M., Binder, R.A., Marshall, M.W., Schoene, N.W., Jencks, J.A. and Mackin, J.F. Haemostasis 3:306 (1974)

    Google Scholar 

  112. Fleischman, A.I., Justice, D., Bierenbaum, M.L., Stier, A. and Sullivan, A. J. Nutrition 105: 1286 (1975)

    CAS  Google Scholar 

  113. Hornstra, G., Lewis, B., Chait, A., Turpeinen, O., Karvonen, M.J. and Vergroesen, A.J. Lancet 1: 1155 (1973)

    Article  PubMed  CAS  Google Scholar 

  114. Wu, K.K., Armstrong, M.L., Hoak, J.C. and Megan, M.B. Thrombos. Res. 7:917 (1975)

    Article  CAS  Google Scholar 

  115. Oversohl, K., Bassenge, E. and Schmid-Schonbein, H. Thrombos. Res. 7: 481 (1975)

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

    M. A. Packham, J.-P. Cazenave, R. L. Kinlough-Rathbone & J. F. Mustard

  2. Department of Pathology, McMaster University, Hamilton, Ontario, Canada

    M. A. Packham, J.-P. Cazenave, R. L. Kinlough-Rathbone & J. F. Mustard

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  1. M. A. Packham
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  2. J.-P. Cazenave
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  3. R. L. Kinlough-Rathbone
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  4. J. F. Mustard
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Editors and Affiliations

  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  2. Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

    Rodolfo Paoletti

  3. Division of Research, The Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes

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Packham, M.A., Cazenave, JP., Kinlough-Rathbone, R.L., Mustard, J.F. (1978). Drug Effects on Platelet Adherence to Collagen and Damaged Vessel Walls. In: Kritchevsky, D., Paoletti, R., Holmes, W.L. (eds) Drugs, Lipid Metabolism, and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 109. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0967-3_14

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  • DOI: https://doi.org/10.1007/978-1-4684-0967-3_14

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