Skip to main content
SpringerLink
Log in

Analysis of Pedigree Data

  • Chapter
Book cover Advances in Human Genetics 1

Abstract

A pedigree is defined by a series of individuals connected by the bonds of parentage and possessing various characteristics, either attributes or variates, at one or several times. The unit from which any pedigree may be assembled involves an identity, a pair of parental identities, and a set of one or more characters, of the form of Fig. 1.

Part of this work was done while the author was at the New York Blood Center, and was supported by grant HE 09011 from the National Institutes of Health.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  1. Berg, K., and A. G. Beam,Progress in Medicine. Genetics (1968).

    Google Scholar 

  2. Carter, C. O., Inheritance of congenital pyloric stenosis, Brit. Med. Bull. 17(3):251–253 (1961).

    PubMed  CAS  Google Scholar 

  3. Ceppelini, R.,et aL, Genetics of leukocyte antigens: a family study of segregation and linkage, in “Histocompatibility Testing” (E. S. Curtoni et aL, eds.), pp. 149–187, Williams & Wilkins, Baltimore (1967).

    Google Scholar 

  4. Chung, C. S., O. W. Robison, and N. E. Morton, A note on deaf mutism, Ann. Hum. Genet. 23:357–366 (1959).

    Article  PubMed  CAS  Google Scholar 

  5. Edwards, A. W. F., in “Conference on Computer Application to Genetics,” in press.

    Google Scholar 

  6. Edwards, J. H., A note on the practical interpretation of 2 x 2 tables, Brit, J. Prev. Soc. Med. 11:73 (1957).

    CAS  Google Scholar 

  7. Edwards, J. H., The Simulation of Mendelism, Acta Genet. Statist. Med. 10:63 (1960).

    PubMed  CAS  Google Scholar 

  8. Edwards, J. H., The genetic basis of common disease, Am. J. Med. 34:627 (1963).

    Article  Google Scholar 

  9. Edwards, J. H., Linkage studies of whole populations,in “Proc. Ill Int. Congress on Human Genetics,” p. 479 (1966).

    Google Scholar 

  10. Edwards, J. H., in “Record Linkage in Medicine,” (E. D. Acheson, ed.), Livingstone, London (1968).

    Google Scholar 

  11. Edwards, J. H., The familial predisposition in man, Brit. Med. Bull. 25:58 (1969).

    PubMed  CAS  Google Scholar 

  12. Everitt, P. F., Supplementary tables for finding the correlation coefficient from tetrachoric groupings, Biometrika VIII:385 (1914).

    Google Scholar 

  13. Falconer, D. S., “An Introduction to Quantitive Genetics,” Oliver & Boyd, London (1960).

    Google Scholar 

  14. Falconer, D. S., The inheritance of liability to certain diseases, estimated from the incidence among relatives, Ann. Hum. Genet. 29:51 (1965).

    Article  Google Scholar 

  15. Falconer, D. S., The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitus, Ann. Hum. Genet. 31:1 (1967).

    PubMed  CAS  Google Scholar 

  16. Fisher, R. A., The correlation between relatives on the supposition of Mendelian inheritance. Trans. Roy. Soc. Edinburgh 52:399 (1918).

    Google Scholar 

  17. Fisher, R. A., “The Genetical Theory of Natural Selection” (1930).

    Google Scholar 

  18. Galton, F., Co-relations and their measurement, chiefly from anthropometric data, Proc. Roy. Soc. XLV:135 (1888).

    Google Scholar 

  19. Haldane, J. B. S., The estimation of the frequencies of recessive conditions in man, Ann. Hum. Genet. 8:255–262 (1938).

    Article  Google Scholar 

  20. Holt, Sarah B., Quantitative genetics of finger-print patterns, Brit. Med. Bull. 17:247–250 (1961).

    PubMed  CAS  Google Scholar 

  21. Karn, M. N., and L. S. Penrose, Birthweight and gestation time in relation to maternal age, parity and infant survival, Ann. Hum. Genet. 16:147–164 (1951).

    Article  CAS  Google Scholar 

  22. Lee, A., and K. Pearson, On the laws of inheritance in man. 1. Inheritance of physical characters, Biometrika 2:357.

    Google Scholar 

  23. Lejeune, J., Sur une solution “¿z priori’’ de la méthode “ût posteriori’’ de Haldane, Biometrics 14:513–520 (1958).

    Article  Google Scholar 

  24. MacDonell, W. R., A study of the variation and correlation of the human skull, with special reference to English crania, Biometrika 3:191 (1904).

    Google Scholar 

  25. McKusick, V. A., and H. E. Cross, in “Record Linkage in Medicine,” (E. D. Acheson, ed.), Livingstone, London (1968).

    Google Scholar 

  26. Maynard-Smith, S., L. S. Penrose, and C. A. B. Smith, “Mathematical Tables for Research Workers in Human Genetics,” Churchill, London (1961).

    Google Scholar 

  27. Mi, M.-P., Segregation analysis. Am. J. Hum. Genet. 19:313–321 (1967).

    PubMed  CAS  Google Scholar 

  28. Moran, P. A. P., and C. A. B. Smith, Commentary on R. A. Fisher’s paper on The Correlation between Relatives on the Supposition of Mendelian Inheritance, Eugenics Laboratory Memoirs, Vol. XLI, pp. 1–62 (1967).

    Google Scholar 

  29. Morton, N. E., Sequential tests for the detection of linkage. Amer. J. Hum. Genet. 7:277–318 (1955).

    PubMed  CAS  Google Scholar 

  30. Morton, N. E., Further scoring types in sequential linkage tests with a critical review of autosomal and partial sex linkage in man. Amer. J. Hum. Genet. 9:55–75 (1957).

    PubMed  CAS  Google Scholar 

  31. Morton, N. E., Genetic tests under incomplete ascertainment, Amer. J. Hum. Genet. 11:1–17(1959).

    Google Scholar 

  32. Morton, N. E., and C. S. Chung, Are the MN blood groups maintained by selection? Amer. J. Hum. Genet. 11:237–251 (1959).

    PubMed  CAS  Google Scholar 

  33. Morton, N. E.,in “Conference on Computer Application to Genetics, 1968,” in press.

    Google Scholar 

  34. Pearson, K., On the laws of inheritance in man, II. On the inheritance of the mental and moral characters in man and its comparison with the inheritance of the physical characters, Biometrika 3:131 (1904).

    Google Scholar 

  35. Pearson, K., “Tables for Statisticians and Biometricians,” C.U.P. (1914).

    Book  Google Scholar 

  36. Penrose, L. S., The genetical background of common diseases. Acta Genet. (Basel) 4:257 (1953).

    CAS  Google Scholar 

  37. Race, R. R., and R. Sanger, “Blood Groups in Man,” Blackwell, Oxford (1968).

    Google Scholar 

  38. Record, R. G., and J. H. Edwards, Environmental influences related to the aetiology of congenital dislocation of the hip, Brit. J. Prev. Soc. Med. 12:8 (1958).

    CAS  Google Scholar 

  39. Renwick, J. H., Progress in mapping human autosomes, Brit. Med. Bull. 25:65 (1969).

    PubMed  CAS  Google Scholar 

  40. Renwick, J. H., Nail-patella syndrome; evidence for modification by alleles at the main locus, Ann. Hum. Genet. 21:159 (1956).

    Article  PubMed  CAS  Google Scholar 

  41. Renwick, J. H., and D. Boiling, A program-complex for encoding, analyzing and storing human linkage data, Amer. J. Hum. Genet. 19:360–367 (1962).

    Google Scholar 

  42. Renwick, J. H., and S. D. Lawler, Genetical linkage between the ABO and nail-patella loci, Ann. Hum. Genet. 19:312 (1955).

    Article  PubMed  CAS  Google Scholar 

  43. Wright, S., Coefficients of inbreeding and relationship, Amer. Naturalist 56:330 (1922).

    Article  Google Scholar 

  44. Vogel, F., and J. Krüger, Multifactorial determination of genetic affections,in “Proc. of the III International Congress on Human Genetics,” p. 437 (1966).

    Google Scholar 

  45. Yasuda, N., An extension of Wahlund’s principle to evaluate mating type frequency, Amer. J. Hum. Genet. 20:1–23 (1968).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human Genetics, University of Birmingham, Birmingham, England

    J. H. Edwards

Authors
  1. J. H. Edwards
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Human Genetics, University College London, London, England

    Harry Harris (Galton Professor) (Galton Professor)

  2. Mount Sinai School of Medicine, The City University of New York, USA

    Kurt Hirschhorn (Arthur J. and Nellie Z. Cohen Professor of Genetics and Pediatrics) (Arthur J. and Nellie Z. Cohen Professor of Genetics and Pediatrics)

Rights and permissions

Reprints and permissions

Copyright information

© 1970 Plenum Press, New York

About this chapter

Cite this chapter

Edwards, J.H. (1970). Analysis of Pedigree Data. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0958-1_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-0958-1_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0960-4

  • Online ISBN: 978-1-4684-0958-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation