Abstract
It is apparent from previous work that the major brain phospholipids are synthesized in the endoplasmic reticulum and in vivo are transferred to ‘myelin’ in both developing and mature animals (l). Nevertheless, no transfer of phospholipids from ‘microsomes’ to ‘myelin’ has been demonstrated in vitro (2), after subcellular fractionation, as it has been between ‘microsomes’ and mitochondria. One possible reason for the failure of workers to establish phospholipid exchange with myelin in the usual simple in vitro test systems employed is that subcellular fractionation may disrupt some critical structures required for exchange in this particular instance. A second possibility may be that the exchange reactions are too slow to be ever detected in the 60 or 90 min incubations used by most workers investigating phospholipid exchange.
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© 1976 Plenum Press, New York
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Dawson, R.M.C., Gould, R.M. (1976). Renewal of Phospholipids in the Myelin Sheath. In: Porcellati, G., Amaducci, L., Galli, C. (eds) Function and Metabolism of Phospholipids in the Central and Peripheral Nervous Systems. Advances in Experimental Medicine and Biology, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0955-0_9
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DOI: https://doi.org/10.1007/978-1-4684-0955-0_9
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