Abstract
Several studies have been carried out in recent years on the chemical modification of brain white matter lipids in various pathological conditions, and particular attention has been given to “demyelination” occurring in inflammatory, traumatic, vascular and tumoral conditions. Many evidences indicate, as a most significative result, the increase of cholesterol esters in nervous tissue. These compounds, normally absent in adult brain tissue, increase in fact drammatically either in demyelinated areas or in apparently normal white matter, as already indicated long ago by Cumings (1953;1955). For this reason cholesterol ester metabolism has been largely studied, either in normal growing brain (Pritchard, 1964) and in normal adult brain or in pathological brain tissue.
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Inzitari, D., Bartolini, L., de Medio, G.E., Amaducci, L. (1976). Possible Effects of Serum Transferases on Brain Phospholipid Metabolism. In: Porcellati, G., Amaducci, L., Galli, C. (eds) Function and Metabolism of Phospholipids in the Central and Peripheral Nervous Systems. Advances in Experimental Medicine and Biology, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0955-0_28
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DOI: https://doi.org/10.1007/978-1-4684-0955-0_28
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