Abstract
The relation of the chemical structure of heparin to its anticoagulant activity has been of interest for many years (4, 8, 11), and much information has accumulated on it. However, study of this has been complicated by the variability in composition of heparin (1) and by its chemical similarity to some other mucopolysaccharides with which it is often associated in tissues. It is now possible to isolate heparin that is nearly free of contaminating polysaccharides and has high biologic activity, but this was not always so. Thus, some of the early reports of the effects of molecular size or sulfate concentration on biologic activity are difficult to assess. Because earlier preparations generally had lower and more variable anticoagulant activity than current ones, conflicting reports of the relation of various characteristics to biologic activity have appeared, and the problem is made more difficult by the lack of full knowledge of the chemical structure of heparin and by the complexity of its possible structural arrangements.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barlow, G.H., Coen, L.J. and Mozen, M.M., Biochim. Biophys. Acta, 83 (1964) 272.
Barlow, G.H., Sanderson, N.D. and McNeill, P.G., Arch. Biochem. Biophys., 115 (1961) 360.
Braswell, E., Biochim. Biophys. Acta, 158 (1968) 103.
Brimacombe, J.S. and Webber, J.M., Mucopolysaccharides, (1964) Elsevier Publishing Co., Amsterdam, p. 92.
Cifonelli, J.A., Carbohyd. Res., in press.
Cifonelli, J.A. and King, J., Biochim. Biophys. Acta, 320 (1973) 331.
Danishefsky, I., Steiner, H., Bella, A. and Friedlander, A., J. Biol. Chem., 224 (1969) 1741.
Foster, A.B. and Huggard, A.J., in Advances in Carbohydrate Chemistry, (Eds. Wolfrom, M.L. and Tipson, R.S. ), Academic Press, New York, 1955, vol. 10, p. 335.
Foster, A.B., Martlew, E.F. and Stacey, M., Chem. Ind., 899 (1953).
Jaques, L.B. and Bell, H.J., in Methods of Biochemical Analysis, ( Ed ). Glick, D.). 1959, vol. 7, p. 253.
Jeanloz, R.W., in The Carbohydrates (Eds. Pigman, W. and Horton, D.), Academic Press, New York, vol. IIB, p. 609.
Kuo, S.H., Jaques, L.B. and Millar, G.J., J. Pharm. Pharmac., 24 (1972) 858.
Laurent, T.C., Arch. Biochem. Biophys., 92 (1961) 224.
Liberti, P.A. and Stivala, S.S., Arch. Biochem. Biophys., 119 (1967) 510.
Lloyd, A.G., Embery, G. and Fowler, L.J., Biochem. Pharmacol., 20 (1971) 637.
Patat, F. and Elias, H.-G., Naturwissenschaften, 46 (1959) 322.
Perlin, A.S., Mackie, D.M. and Dietrich, C.P., Carbohyd. Res., 18 (1971) 185.
Rezansoff, W.E. and Jaques, L.B., Thromb. Diath. Haemorrh., 18 (1967) 150.
Rodén, L., Baker, J., Cifonelli, J.A. and Mathews, M.B., in Methods of Enzymology (Ed. Ginsburg, V ), Academic Press, New York, 1972, vol. 28, p. 73.
Stivala, S.S., Yuan, L., Ehlich, J. and Liberti, P.A., Biochem. Biophys., 122 (1967) 32.
Taylor, R.L., Shively, J.E., Conrad, H.E. and Cifonelli, J.A., Biochem., 12 (1973) 3633.
Wolfrom, M.L., Wang, P.Y. and Honda, S., Carbohyd. Res., 11 (1969) 179.
Foster, A.B., Martlew, E.F. and Stacey, M., Chem. Ind., 899 (1953).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Plenum Press, New York
About this chapter
Cite this chapter
Cifonelli, J.A. (1975). Relation of Chemical Structure of Heparin to Its Anticoagulant Activity. In: Bradshaw, R.A., Wessler, S. (eds) Heparin. Advances in Experimental Medicine and Biology, vol 52. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0946-8_8
Download citation
DOI: https://doi.org/10.1007/978-1-4684-0946-8_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-0948-2
Online ISBN: 978-1-4684-0946-8
eBook Packages: Springer Book Archive