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The Functional Roles of Metals in Metalloenzymes

  • J. F. Riordan
  • B. L. Vallee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 48)

Abstract

There is now widespread appreciation for the fact that overall and local changes in protein conformation are critical to the mechanism of enzymatic catalysis. Yet, it has been difficult to document the occurrence and judge the significance of such changes, since methods for the analysis of protein structure often require conditions which cannot be compared easily and directly with those designed for determining function. This is true even while the number, resolving power and sophistication of suitable approaches has increased rapidly.

Keywords

Metal Atom Circular Dichroic Spectrum Zinc Atom Metal Binding Site Neutral Protease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • J. F. Riordan
    • 1
  • B. L. Vallee
    • 1
  1. 1.Biophysics Research Laboratory, Department of Biological ChemistryHarvard Medical SchoolBostonUSA

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