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Effect of SV4O Infection on DNA Polymerase Activity in Monkey Cells

  • Chapter
DNA Synthesis

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 17))

Abstract

Infection of permissive host cells by either simian virus 40 (SV4O) or polyoma virus causes a wide spectrum of changes in cell metabolism. The activities of a number of enzymes concerned with DNA metabolism increase; host cell DNA synthesis is usually initiated and one round of DNA replication appears to occur; cell histone and non-histone chromosomal proteins are synthesized at increased rates. Changes in the cell surface and in cell morphology occur, along with the expression of viral specific non-capsid antigens, such as T, U, or TSTA (references 1–5 are recent reviews of SV4O and polyoma virus molecular biology). We have carried out experiments examining one aspect of this virushost cell interaction more closely: the effect of SV4O infection on monkey cell DNA polymerase activity.

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Author information

Author notes

  1. Silvano Riva

    Present address: Laboratorio di Genetica Biochimica ed Evoluzionistica, Consiglio Nazionale delle Richerche, Pavia, Italy

Authors and Affiliations

  1. Department of Biochemistry, University of Florida, Gainesville, Florida, 32610, USA

    Silvano Riva, Martha A. Cline & Philip J. Laipis

Authors
  1. Silvano Riva
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  2. Martha A. Cline
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  3. Philip J. Laipis
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Editor information

Editors and Affiliations

  1. Imperial Cancer Research Fund, London, England

    Ian Molineux

  2. University of Paris, Paris, France

    Masamichi Kohiyama

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© 1978 Plenum Press, New York

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Riva, S., Cline, M.A., Laipis, P.J. (1978). Effect of SV4O Infection on DNA Polymerase Activity in Monkey Cells. In: Molineux, I., Kohiyama, M. (eds) DNA Synthesis. NATO Advanced Study Institutes Series, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0844-7_46

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  • DOI: https://doi.org/10.1007/978-1-4684-0844-7_46

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0846-1

  • Online ISBN: 978-1-4684-0844-7

  • eBook Packages: Springer Book Archive

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