Abstract
In the search for bioactive compounds from marine sources, the selection of specific organisms and classes of compounds to be studied is dictated by bioassay, rather than the conscious choice of the investigator. As a result, efforts are often not focused on a given phylum or class of compounds. Instead, animals from different phyla and compounds varying greatly in size, type, and structural complexity are dealt with. The collection of different organisms and assorted types of natural products described in this paper illustrates these points.
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Dr. Schmitz has requested that the authorship of this paper be quoted as follows: F. J. Schmitz, D. C. Campbell, K. Hollenbeak, D. J. Vanderah, L. S. Ciereszko, P. Steudler, J. D. Ekstrand, D. van der Helm, P. Kaul, and S. Kulkarni.
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References
F. J. McDonald, D. C. Campbell, D. J. Vanderah, F. J. Schmitz, D. M. Washecheck, J. E. Burks, and D. van der Helm, J. Org. Chem. 40, 665 (1975).
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100 MHz (CDCI3) 1.07(d, 3, 2°-Me), 1.24 (s, 3, 3°-Me), 1.68 (br s, 3, vinyl Me), 4.73 (m, 2, = CH2), 5.36 (br m, 1,-CH=C(CH3)-), 5.94 (ABq, 1, J = 12, 16,-CH=CH), 5.06 (dd, 1, J = 12, 2,-CH=CH2), 5.20 (dd, 1, J = 16, 2,-CH=CH2).
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Calcd for C28H38O9: C, 64.86; H, 7.38; M+ 518.2518; Found: C, 64.90; H, 7.32, M+ 518.24888.
D. J. Vanderah, P. A. Steudler, L. S. Ciereszko, F. J. Schmitz, J. D. Ekstrand, and D. van der Helm, J. Am. Chem. Soc., submitted.
J. B. Hendrickson, Tetrahedron 7, 82 (1959).
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© 1977 Plenum Press, New York
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Schmitz, F.J. (1977). Chemistry Related to the Search for Drugs from the Sea. In: Faulkner, D.J., Fenical, W.H. (eds) Marine Natural Products Chemistry. Nato Conference Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0802-7_24
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DOI: https://doi.org/10.1007/978-1-4684-0802-7_24
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