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The Topical Effects of Nickel Subsulfide on Renal Parenchyma

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Inorganic and Nutritional Aspects of Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 91))

Abstract

Earlier investigations have shown that nickel subsulfide (Ni3S2) is a potent carcinogen when injected intramuscularly in rats.(1,2) More recently we found that intrarenal injection of this metal salt causes malignant tumors in the rat kidney.(3,4) Interestingly, these animals become plethoric soon after application of the carcinogen and the reaction subsides after removal of the injected kidney. (5) The early cellular changes mainly involve the distal tubule lining cells with typical inclusions in the nuclei and the mitochondria. (6) So far, these events are only demonstrable in the rat, and there is, as yet, no clear-cut evidence that they are interrelated. In the present paper, we shall report these and other pertinent findings regarding the topical effects of Ni3S2 on the kidney parenchyma.

This work was supported by a grant from the Medical Research Council of Canada (No. MA-1827).

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References

  1. Gilman, J. P. W., Cancer Research 22, Page 158, 1962.

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  2. Jasmin, G., Bajusz, E. and Mongeau, A., Revue Canadienne de Biologie 22, Page 113, 1963.

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  3. Jasmin, G., J. Microscopie 17, Page 68a, 1973.

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  4. Jasmin, G. and Riopelle, J. L., Laboratory Investigations 35, Page 71, 1976.

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  5. Jasmin, G. and Solymoss, B., Proceedings Soc. Exp. Biol. Med. 148, Page 774, 1975.

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  6. Jasmin, G., J. Microscopie et Biol. Cel. 23, Page 54a, 1975.

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  7. Jasmin, G., British J. Cancer XVII, Page 618, 1964.

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  8. Jasmin, G., (unpublished data).

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  9. Solymoss, B. and Jasmin, G., Exper. Haematology (in press).

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Author information

Authors and Affiliations

  1. Départment de Pathologie, Faculté de Médecine, Université de Montréal, Canada

    Gaëtan Jasmin & Béla Solymoss

Authors
  1. Gaëtan Jasmin
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  2. Béla Solymoss
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Editor information

Editors and Affiliations

  1. University of California at San Diego, La Jolla, California, USA

    G. N. Schrauzer

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© 1978 Plenum Press, New York

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Jasmin, G., Solymoss, B. (1978). The Topical Effects of Nickel Subsulfide on Renal Parenchyma. In: Schrauzer, G.N. (eds) Inorganic and Nutritional Aspects of Cancer. Advances in Experimental Medicine and Biology, vol 91. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0796-9_5

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  • DOI: https://doi.org/10.1007/978-1-4684-0796-9_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0798-3

  • Online ISBN: 978-1-4684-0796-9

  • eBook Packages: Springer Book Archive

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