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Prostaglandins

  • Chapter
Mediators of Inflammation

Abstract

In 1930, two New York City gynecologists (Kurzrok and Lieb, 1930) observed that human myometrium exhibited rhythmic contractions and relaxation when incubated with fresh human semen. Goldblatt (1933) and von Euler (1936) independently confirmed this finding and identified the active principle as an acidic lipid, which von Euler believed to be produced in the prostate gland and therefore named “prostaglandin.” Eliasson (1959) later demonstrated that prostaglandin in human semen is in fact derived from seminal vesicles. Bergström and Sjövall (1957, 1960) determined that the active component was not a single substance but several closely related compounds. These investigators isolated two of the substances in crystalline form from homogenates of sheep vesicular glands and described their chemical structure (Bergström et al., 1962).

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  1. Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA

    Robert B. Zurier

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  1. Department of Medicine Division of Rheumatology School of Medicine, New York University Medical Center, New York, New York, USA

    Gerald Weissmann

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Zurier, R.B. (1974). Prostaglandins. In: Weissmann, G. (eds) Mediators of Inflammation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0745-7_7

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