Environmental Lung Disorders Induced by Organic (Nonmineral) Agents

  • Miriam Sperber


A large variety of precipitating organic agents can be inhaled as fine particles or aerosols, including proteins of animal origin, pathogenic microorganisms, fungal spores, mineral oils, and several organic chemicals. Specific occupational disorders have been found to result from exposure to these offending substances. In addition to these exogenous antigens, endogenous antigens may be released from infectious agents invading the bronchopulmonary area, such as Aspergillus fumigatus.


Hypersensitivity Pneumonitis Clin Allergy Organic Agent Allergic Bronchopulmonary Aspergillosis Extrinsic Allergic Alveolitis 
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  1. 1.
    Hapke EJ, Seal RMF, Thomas GO, Hayes M, Meek JC: Farmer’s lung: A clinical, radiographic, functional and serological correlation of acute and chronic stages. Thorax 23:451–468, 1968PubMedCrossRefGoogle Scholar
  2. 2.
    Kawanami O, Basset F, Barrios R, Lacronique JG, Ferrans VJ, Crystal RG: Hypersensitivity pneumonitis in man. Light and electron microscopic studies of 18 lung biopsies. Am J Pathol 110:275–289, 1983PubMedGoogle Scholar
  3. 3.
    Cotes JE, Steel J: Work-Related Lung Disorders. Oxford, England, Blackwell Scientific Publications, 1987, pp 320–345Google Scholar
  4. 4.
    Burrell R, Rylander R: A critical review of the role of precipitins in hypersensitivity pneumonitis. Eur J Respir Dis 62:332–343, 1981Google Scholar
  5. 5.
    Avila R: Some aspects of occupational asthma.Clin Allergy 13:191–195, 1983PubMedCrossRefGoogle Scholar
  6. 6.
    Hensley GT, Garancis JC, Cherayil GD, Fink IN: Lung biopsies of pigeon breeders’ disease. Arch Pathol 87: 572–579, 1969PubMedGoogle Scholar
  7. 7.
    Cross T, Maciver AM: The thermophilic actinomycetes in mouldy hay. J Gen Microbiol 50:351–359, 1968PubMedGoogle Scholar
  8. 8.
    Dickie HA, Rankin J: Farmer’s lung: An acute granulomatous interstitial pneumonitis occurring in agricultural workers. JAMA 167: 1069, 1958CrossRefGoogle Scholar
  9. 9.
    Reyes CN, Wenzel FJ, Lawton BR, Emanuel DA: The pulmonary pathology of farmers’ lung disease. Chest 81:142–146, 1982PubMedCrossRefGoogle Scholar
  10. 10.
    Braun SR, do Pico GA, Tsiatis A, Horvath E, Dickie HA, Rankin J: Farmers’ lung disease: Long-term clinical and physiologic outcome. Am Rev Respir Dis 119: 185–191, 1979PubMedGoogle Scholar
  11. 11.
    Christensen LT, Schmidt CD, Ribbins L: Pigeon breeder’s disease-a prevalence study and review. Clin Allergy 5:417–430, 1975Google Scholar
  12. 12.
    British Thoracic Society: A national survey of bird fancier’s lung including its possible association with jejunal villous atrophy. Br J Chest 78:75–87, 1984CrossRefGoogle Scholar
  13. 13.
    Allen DH, Williams GV, Woolcock AJ: Bird breeder’s hypersensitivity pneumonitis: Progress studies of the lung function after cessation of exposure to the provoking antigen. Am Rev Respir Dis 114:555–566, 1976PubMedGoogle Scholar
  14. 14.
    Andersen P, Christensen KM, Jensen BE, Axel K, Laursen JCS, Geday H, Lunsgaard A, Anderson HK: Antibodies to pigeon antigens in pigeon breeders. Eur J Respir Dis 63: 113–121, 1982Google Scholar
  15. 15.
    Schaffner W, Drutz DJ, Duncan GW, Koenig MG: The clinical spectrum of endemic psittacosis. Arch Intern Med 119:433, 1967Google Scholar
  16. 16.
    Hearn CED: Bagassosis: An epidemiological, environmental and clinical survey. Br J Ind Med 25:267–282 1968Google Scholar
  17. 17.
    Well H, Buechner HA, Gonzalez E, Herbert SJ, Ancoin E, Ziskind MM: Bagassosis: A study of pulmonary function in 20 cases. Ann Intern Med 64:737–747, 1966Google Scholar
  18. 18.
    Bouhuys A, Heaphy LJ Jr, Schilling RSF, Welborn JW: Byssionosis in the United States. N Engl J Med 277: 170, 1967PubMedCrossRefGoogle Scholar
  19. 19.
    Bouhuys A, Van de Woestijne KP: Respiratory mechanics and dust exposure in byssinosis. J Clin Invest 49: 106, 1970PubMedCrossRefGoogle Scholar
  20. 20.
    Pimentel JC, Avila R: Respiratory disease in cork workers (suberosis). Thorax 28:409–423, 1973PubMedCrossRefGoogle Scholar
  21. 21.
    Campbell, JA, Kryda MJ, Treuhaft MW: Cheese worker’s hypersensitivity monitis. Am Rev Respir Dis 127:495–496, 1983PubMedGoogle Scholar
  22. 22.
    Stewart CJ, Pickering CAC: Mushroom worker’s lung. Lancet 1:317,1974PubMedCrossRefGoogle Scholar
  23. 23.
    Babaszak EF, Thiede WH, Fink JN: Hypersensitivity pneumonitis due to contamination of an air conditioner. N Engl J Med 283:271–276, 1970CrossRefGoogle Scholar
  24. 24.
    Belin L: Prevalence of symptoms and immunoresponse in relation to exposure to infected humidifiers. Eur J Respir Dis 61:155–162,1980Google Scholar
  25. 25.
    Fink JN, Banaszak EF, Baroriak JJ, Hensley GT, Kurup VP: Interstitial lung disease due to contamination of forced air system. Ann Intern Med 84:406–413, 1976PubMedGoogle Scholar
  26. 26.
    Grant JWB, Blackadder ES, Greenberg M, Blyth W: Extrinsic allergic alveolitis in Scottish maltworkers. Br Med J 1:490–493, 1976CrossRefGoogle Scholar
  27. 27.
    Cohen HI, Merigan TC, Kosek JC, Eldridge F: A granulomatous pneumonitis associated with red wood sawdust inhalation. Am J Med 43:785–794, 1967PubMedCrossRefGoogle Scholar
  28. 28.
    Coombs RRA, Gell PGH: Classification of allergic reactions responsible for clinical hypersensitivity and disease, in Gell PGH, Coombs RRA (eds): Clinical Aspects of Immunology. Oxford, England, Blackwell Scientific Publications, 1968Google Scholar
  29. 29.
    Parkes WR: Occupational Lung Disorders ed 2. London, Butterworth, 1983Google Scholar
  30. 30.
    Wuthe H, Bergmann K, Vogel J: Frequency of lung function disturbances and immunological status of industrial poultry farmers. Eur J Respir Dis 62:38–39, 1981Google Scholar
  31. 31.
    Lee TH, Wraith GD, Bennett CO, Bentley, AP: Budgerigar fancier’s lung: The persistence of budgerigar precipitins and the recovery of lung function after cessation of avian exposure. Clin Allergy 13:197–202, 1983PubMedCrossRefGoogle Scholar
  32. 32.
    Scibner GH, Barboriak JJ, Fink IN: Prevalence of precipitins in groups at risk of developing hypersensitivity pneumonitis. Clin Allergy 10:91–95, 1980CrossRefGoogle Scholar
  33. 33.
    Turton CWG, Firth G, Grundy E, Rigden BG, Smyth JT, Turner-Warwick M: Raised enzyme markers of chronic inflammation in asymptomatic farmers’ lung. Thorax 36:122–125, 1981PubMedCrossRefGoogle Scholar

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© Springer-Verlag New York Inc. 1990

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  • Miriam Sperber

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