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The Protozoa

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Abstract

Protozoans are an extremely diverse group of unicellular animals. As free-living organisms they are found in virtually every ecological niche, such as bottoms of the deepest marine trenches, salt lakes, edges of ice flows, and even certain thermal springs. As parasites, they infect all species of vertebrates and many invertebrates, in which they have adapted to life in nearly all available sites within the body of the host.

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References

  1. Honigberg BM: Trichomonads of importance in human medicine. In Kreier JP (ed): Parasitic Protozoa, Vol 2. New York, Academic Press, 1978, pp 275–454

    Google Scholar 

  2. Donne A: Animalcules observes dans la matieres purulentes et le produit des secretions des organes genitaux de l’homme et de la femme. C R Hebdomad Seanc Acad Sci 3:385–386, 1837

    Google Scholar 

  3. Ehrenberg CO: Die Infusionsthierchen als vollkommenen Organismen. Leipzig, Voss, 1838

    Google Scholar 

  4. Kessel JF, Gafford JA: Observations on the pathology of trichomonas vaginitis and on vaginal implants with Trichomonas vaginalis and Trichomonas intestinalis. Am J Obstet Gynecol 39:1005–1014, 1940

    Google Scholar 

  5. Müller M: The hydrogenosome. In Gooday GW, Lloyd D, Trine APJ (eds): The Eukaryotic Microbial Cell. Symposium 30. Cambridge, Cambridge University Press, 1980, pp 127–142

    Google Scholar 

  6. Mack SR, Müller M: End products of carbohydrate metabolism in Trichomonas vaginalis. Comp Biochem Physiol 67B:213–216, 1980

    CAS  Google Scholar 

  7. Littlewood JM, Kohler HG: Urinary tract infection by Trichomonas vaginalis in a newborn baby. Arch Dis Child 41:693–695, 1966

    Article  PubMed  CAS  Google Scholar 

  8. Alderete JF, Garza GE: Specific nature of Trichomonas vaginalis parasitism of host cell surfaces. Infect Immun 50:701–708, 1985

    PubMed  CAS  Google Scholar 

  9. Krieger NJ, Ravdin JI, Rein MF: Contact-dependent cytopathogenic mechanisms of Trichomonas vaginalis. Infect Immun 50:778–786, 1985

    PubMed  CAS  Google Scholar 

  10. Krieger JN, Holmes KK, Spence MR, et al.: Geographic variation among isolates of Trichomonas vaginalis: demonstration of antigenic heterogenicity by using monoclonal antibodies and the indirect fluorescence test. J Infect Dis 152:979–984, 1985

    Article  PubMed  CAS  Google Scholar 

  11. Müller M, Meingassner JG, Miller WA, et al.: Three metronidazole-resistant strains of Trichomonas vaginalis from the United States. Am J Obstet Gynecol 138:808–812, 1980

    PubMed  Google Scholar 

  12. Osterholm MT, Forfang JC, Ristinen TL, et al.: An outbreak of food-borne giardiasis. N Engl J Med 304:24–28, 1981

    Article  PubMed  CAS  Google Scholar 

  13. Shaw PK, Brodsky RE, Lyman DO, et al.: A communitywide outbreak of giardiasis with evidence of transmission by a municipal water supply. Ann Intern Med 87:421–426, 1977

    Google Scholar 

  14. Schmerin MJ, Jones TC, Klein H: Giardiasis: Association with homosexuality. Ann Intern Med 88:801–803, 1978

    PubMed  CAS  Google Scholar 

  15. Sagi EF, Shapiro M, Deckelbaum, R: Giardia lamblia: Prevalence, influence on growth, and symptomatology in healthy nursery children. Israel J Med Sci 19:815–817, 1983

    Google Scholar 

  16. Pickering LK, Woodward WE, Dupont HL, et al.: Occurrence of Giardia lamblia in children in day care centers. J Pediatr 104:522–526, 1984

    Article  PubMed  CAS  Google Scholar 

  17. Davies RB, Hibler CP: Animal reservoirs and cross-species transmission of Giardia. In Jakubowski W, Hoff JC (eds): Waterbome Transmission of Giardiasis. EPA 600/9-79-001, 1979, pp 104–126

    Google Scholar 

  18. Nash TE, McCutchan T, Keister D et al.: Restriction-endonuclease analysis of DNA from 15 giardia isolates obtained from humans and animals. J Infect Dis 152:64–73, 1985

    Article  PubMed  CAS  Google Scholar 

  19. van Leeuwenhoek A: cited by Dobell C. In: Antony van Leeuwenhoek and His “Little Animals.” New York, Dover Publications, 1960, p 224

    Google Scholar 

  20. Lambl VDF: Mikroskopische Untersuchungen der Darm-Excrete. Beitrag zur Pathologic des Darms und zur Diagnostik am Krankenbette. Vierteljahrschrift für die Praktische Heilkunde. Med Fac Prague 1:1–58, 1859

    Google Scholar 

  21. Simon CE: Giardia enterica, a. parasitic intestinal flagellate of man. Am J Hyg 1:440–491, 1921

    Google Scholar 

  22. Lindmark DJ: Energy metabolism of the anaerobic protozoan Giardia lamblia. Mol Biochem Parasitol 1:1–12, 1980

    Article  PubMed  CAS  Google Scholar 

  23. Bingham AK, Jarroll EL Jr, Meyer EA, et al.: Giardia sp.: Physical factors of excystation in vitro, and excystation vs. eosin exclusion as determinants of viability. Exp Parasitol 47:284–291, 1979

    Article  PubMed  CAS  Google Scholar 

  24. Meyer EA: Giardia lamblia: Isolation and axenic cultivation. Exp Parasitol 39:101–105, 1976

    Article  PubMed  CAS  Google Scholar 

  25. Brasitus TA: Parasites and malabsorption. Amer J Med 67:1058–1065, 1979

    Article  PubMed  CAS  Google Scholar 

  26. Levinson JD, Nastro LJ: Giardiasis with total villous atrophy. Gastroenterology 74:271–275, 1978

    PubMed  CAS  Google Scholar 

  27. Ament ME, Rubin CE: Relation of giardiasis to abnormal intestinal structure and function in gastrointestinal immuno-deficiency syndrome. Gastroenterology 62:216–226, 1972

    PubMed  CAS  Google Scholar 

  28. Smith PD: Pathophysiology and immunology of giardiasis. Annu Rev Med 36:295–307, 1985

    Article  PubMed  CAS  Google Scholar 

  29. Nayak N, Ganguly NK, Walia BNS, et al.: Specific secretory IgA in the milk of Giardia lamblia-infected and uninfected women. J Infect Dis 155:724–727, 1987

    Article  PubMed  CAS  Google Scholar 

  30. Gillin FD, Reiner DS, Gault, MJ: Cholate-dependent killing of Giardia lamblia by human milk. Infect Imm 47:619–622, 1985

    CAS  Google Scholar 

  31. Hernell O, Ward H, Blackberg L et al.: Killing of Giardia lamblia by human milk lipases: an effect mediated by lipolysis of milk lipids. J Inf Dis 153:715–720, 1986

    Article  CAS  Google Scholar 

  32. Reiner DS, Wang CS, Gillin FS: Human milk kills Giarda lamblia by generating toxic lipolytic products. J Infect Dis 154:825–832, 1986

    Article  PubMed  CAS  Google Scholar 

  33. Okeahialom TC: Giardiasis in protein energy malnutrition. E Afr Med J 59:765–770, 1982

    Google Scholar 

  34. Mahalanabis D, Simpson TW, Chakrabosty ML, et al.: Malabsorption of water miscible vitamin A in children with giardiasis and ascariasis. Am J Clin Nutr 32:313–318, 1979

    PubMed  CAS  Google Scholar 

  35. Kumath KR, Murugasu R: A comparative study of four methods for detecting Giardia lamblia in children with diarrheal disease and malabsorption. Gastroenterology 66:16–21, 1974

    Google Scholar 

  36. Bezjak B: Evaluation of a new technique for sampling duodenal contents in parasitologic diagnosis. Am J Digest Dis 17:848–850, 1972

    Article  PubMed  CAS  Google Scholar 

  37. Ungar BL, Yolken RH, Nash TE et al.: Enzymelinked immunosorbent assay for the detection of Giardia lamblia in fecal specimens. J Infect Dis 149:90–97, 1984

    Article  PubMed  CAS  Google Scholar 

  38. Green EL, Miles MA, Warhurst DC: Immunodiagnostic detection of giardia antigen in faeces by a rapid visual enzyme-linked immunosorbent assay. Lancet 28:691–693, 1985

    Article  Google Scholar 

  39. Guerrant FL: The global problem of amoebiasis: current status, research needs, and opportunities for progress. Rev Infect Dis 8:218–227, 1986

    Article  PubMed  CAS  Google Scholar 

  40. Pomerantz BM, Marr JS, Goldman WD: Amebiasis in New York City 1958–1978: Identification of the male homosexual high risk population. Bull NY Acad Med 56:232–244, 1980

    CAS  Google Scholar 

  41. Goldmeier D, Sargeaunt PG, Price AB, et al.: Is Entamoeba histolytica in homosexual men a pathogen? Lancet 1:641–644, 1986

    Article  PubMed  CAS  Google Scholar 

  42. Allison-Jones E, Mindel A, Sargeaunt P et al.: Entamoeba histolytica as a commensal intestinal parasite in homosexual men. N Eng J Med 315:353–356, 1986

    Article  Google Scholar 

  43. Losch FA: Massenhafte Entwicklung von Amöben in Dickdarm. Arch Pathol Anat Phys Klin Med Virchow 65:196–211, 1875

    Article  Google Scholar 

  44. Quincke HI, Roos E: Über Amöben-enterids. Berl Klin Wochenschr 30:1089–1094, 1893

    Google Scholar 

  45. Schaudinn F: Untersuchungen über Fortpflanzung einiger Rhizopoden (vorläufige Mitteilung). Arbeiten aus dem Kaiseriichen Gesundheitsamte 19:547–576, 1903

    Google Scholar 

  46. Councilman WT, Lafleur HA: Amebic dysentery. Johns Hopkins Hosp Rep 2:395–548, 1891

    Google Scholar 

  47. Walker EL, Sellards AW: Experimental entamoebic dysentery. Philip J Sci Trop Med 8:230–253, 1913

    Google Scholar 

  48. Boeck WC: Cultivation of Entamoeba histolytica. Am J Hyg 5:371–407, 1925

    Google Scholar 

  49. Dobell C: Researches on the intestinal protozoa of monkeys and man. Parasitology 20:357–412, 1928

    Article  Google Scholar 

  50. Sargeaunt PG, Williams JE, Grene JD: The differentiation of invasive and non-invasive Entamoeba histolytica by isoenzyme electrophoresis. Trans Roy Soc Trop Med Hyg 72:519–521, 1978

    Article  PubMed  CAS  Google Scholar 

  51. Farri TA, Sargeaunt PG, Warhurst DC et al.: Electrophoretic studies of the hexokinase of Entamoeba histolytica groups I and IV. Trans Roy Soc Trop Med Hyg 78:672–673, 1980

    Article  Google Scholar 

  52. Ravdin JI: Pathogenesis of disease caused by Entamoeba histolytica: studies of adherence, secreted toxins and contact-dependent cytolysis. Rev Infect Dis 8:247–260, 1986

    Article  PubMed  CAS  Google Scholar 

  53. Ravdin JI, Murphy CF, Salata RA, et al.: N-acetyl-D-galactosamine-inhibiting adherence lectin of Entamoeba histolytica. I. Partial purification and relation of ameoebic virulence in vitro. J Infect Dis 151:804–815, 1985

    Article  PubMed  CAS  Google Scholar 

  54. Ravdin JI, Guerrant RL: Studies on the cytopathogenicity of Entamoeba histolytica. Arch Invest Med (Mexico) (Suppl. 1) 11:123–128, 1980

    CAS  Google Scholar 

  55. Salata R, Ravdin JR: Reviews of the human immune mechanisms directed against Entamoeba histolytica. Rev Infect Dis 8:261–272, 1986

    Article  PubMed  CAS  Google Scholar 

  56. Sawitz WG, Faust EC: The probability of detecting intestinal protozoa by successive stool examinations. Am J Trop Med 22:131–136, 1942

    Google Scholar 

  57. Kagan IG: Serodiagnosis of parasitic diseases. In Rose NR, Friedman H (eds): Manual of Clinical Immunology, 2nd edition. Washington, DC, American Society for Microbiology, 1980, pp 573–604

    Google Scholar 

  58. Nuti M, De Comarmond C, De Dac C: An edemic focus of balantidiasis in the Seychelles Islands. In: Abstracts of the 10th International Congress of Tropical Medicine and Malaria, 1980, p 13

    Google Scholar 

  59. Malmsten PH: Infusorien als intestinal-Tiere beim Menschen. Arch Pathol Anat Physiol Klin Med (Virchow) 12:302–309, 1857

    Article  Google Scholar 

  60. Wenger F: Abscesso hepatico producido por el Balantidium coli. Kasmera 2:433–435, 1967

    Google Scholar 

  61. Arean VM, Koppisch E: Balantidiasis: A review and report of cases. Am J Pathol 32: 1089–1117, 1956

    PubMed  CAS  Google Scholar 

  62. Nicolle C, Manceaux LH: Sur une infection a coyes de Leishman (ou organismes voisins) du gondi. C R Hebdomad Seance Acad Sci 147:763–766, 1908

    Google Scholar 

  63. Splendore A: Un nuovo protozoa parassita dei conigli: Incontrato nelle lesioni anatomiche d’ua malttia che ricorda in molti punti il Kala-azar dell’uomo. Rev Soc Sci Sao Paulo 3:109–112, 1908

    Google Scholar 

  64. Janku J: Pathogenesis and pathologic anatomy of the “congenital coloboma” of the macula lutea in an eye of normal size, with microscopic detection of parasites in the retina. J Czech Phys 62:1021–1027, 1923

    Google Scholar 

  65. Wolf A, Cowen D, Paige BH: Human toxoplasmosis: Occurrence in infants as encephalomyelitis: Verification by transmission to animals. Science 89:226–277, 1939

    Article  PubMed  CAS  Google Scholar 

  66. Pinkerton H, Henderson RG: Adult toxoplasmosis: A previously unrecognized disease entity simulating the typhus-spotted fever group. JAMA 116:807–814, 1941

    Article  Google Scholar 

  67. Sabin AB: Toxoplasmic encephalitis in children. JAMA 116:801–807, 1941

    Google Scholar 

  68. Frenkel JK, Dubey JP, Miller NL: Toxoplasma gondii in cats: Fecal stages identified as coccidian oocysts. Science 167:893–896, 1970

    Article  PubMed  CAS  Google Scholar 

  69. Hutchinson WM, Dunachie JF, Sim JC et al.: Coccidian-like nature of Toxoplasma gondii. Br Med J 1:142–144, 1970

    Article  Google Scholar 

  70. Desmonts G, Couvrer J: Congenital toxoplasmosis. A prospective study of 378 pregnancies. N Engl J Med 290:1110–1116, 1974

    Article  PubMed  CAS  Google Scholar 

  71. Koppe JG, Loewer-Sieger DH, Roever-Bonnet H: Results of 20-year follow-up of congenital toxoplasmosis. Lancet, 1:254–256, 1986

    Article  PubMed  CAS  Google Scholar 

  72. Masur H, Jones TC, Lempert JA, et al.: Outbreak of toxoplasmosis in a family and documentation of acquired retinochoroidids. Am J Med 64:396–402, 1978

    Article  PubMed  CAS  Google Scholar 

  73. Ruskin J, Remington JS: Toxoplasmosis in the compromised host. Ann Intern Med 84:193–199, 1976

    PubMed  CAS  Google Scholar 

  74. Wanke C, Tuazon CU, Kovacs A et al.: Toxoplasma encephalitis in patients with acquired immune deficiency syndrome: diagnosis and response to therapy. Am J Trop Med Hyg 36:509–516, 1987

    PubMed  CAS  Google Scholar 

  75. Welch PC, Masur H, Jones TC, et al.: Serologic diagnosis of acute lymphadenopathic toxoplasmosis. J Infect Dis 142:256–264, 1980

    Article  PubMed  CAS  Google Scholar 

  76. Dorfman RF, Remington JS: Value of lymph-node biopsy in the diagnosis of acute acquired toxoplasmosis. N Engl J Med 289:878–881, 1973

    Article  PubMed  CAS  Google Scholar 

  77. Haverkos HW: Assessment of therapy for Toxoplasma encephalitis. Am J Med 72:907–914, 1987

    Article  Google Scholar 

  78. Navin, TR, Juranek DD: Cryptosporidium: Clinical, epidemiologic, and parasitologic review. Rev Inf Dis 6:313–327, 1984

    Article  CAS  Google Scholar 

  79. Tzipori S, Angus TW, Grey EW et al.: Diarrhea in lambs experimentally infected with Cryptosporidium isolated from calves. Am J Vet Res 42:1400–1404, 1981.

    PubMed  CAS  Google Scholar 

  80. Current WL, Reese NC, Ernst JV et al.: Human cryptosporidiosis in immunocompetent and immunodeficient persons. N Eng J Med 308:1252–1257, 1983

    Article  CAS  Google Scholar 

  81. Tyzzer EE: A sporozoan found in the peptic glands of the common mouse. Proc Soc Exp Biol Med 5:12–13, 1907

    Google Scholar 

  82. Slavin D: Cryptosporidium meleagridis (Sp. nov.) J Comp Pathol 65:262–266, 1955

    PubMed  CAS  Google Scholar 

  83. Nime FA, Burek JD, Page DL, et al.: Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gasteroenterol 70:592–598, 1976

    CAS  Google Scholar 

  84. Meisel JE, Perera DR, Meloigro C, et al.: Overwhelming water diarrhea associated with Cryptosporidium in an immunosuppressed patient. Gastroenterol 70:1156–1160, 1976

    CAS  Google Scholar 

  85. Bird RG, Smith MD: Cryptosporidiosis in man. Parasite life cycle and fine structural pathology. J Pathol 132:217, 1980

    Article  PubMed  CAS  Google Scholar 

  86. Current WL, Haynes TB: Complete development of Cryptosporidium in cell culture. Science 224:603–605, 1984

    Article  PubMed  CAS  Google Scholar 

  87. Lefkowitch JH, Krumholtz S, Kuo-Ching F-C et al.: Crytosporidiosis of the human small intestine: A light and electron microscopic study. Hum Pathol 15:746–752, 1984

    Article  PubMed  CAS  Google Scholar 

  88. Stemmerman GN, Hayashi T, Glober GA, et al.: Crytosporidiosis: Report of a fatal case complicated by disseminated toxoplasmosis. Am J Trop Med Hyg 69:637–642, 1980

    Google Scholar 

  89. Slope KS, Dormashkin RR, Bird RB et al.: Chronic malabsorption due to crytosporidiosis in a child with immunoglobulin deficiency. Gut 23:80–82, 1982

    Article  Google Scholar 

  90. Sloave R, Danne RL, Lonig CI et al.: Crytosporidiosis in homosexual men. Ann Int Med 100:504–511, 1984

    Google Scholar 

  91. Ma P, Soave R: Three-step stool examination for cryptosporidiosis in 10 homosexual men with protracted watery diarrhea. J Inf Dis 147:824–829, 1983

    Article  CAS  Google Scholar 

  92. Harrison G: Mosquitoes, Malaria, and Man. New York, E P Dutton, 1978

    Google Scholar 

  93. Haggis AW: Fundamental errors in the early history of cinchona. Bull Hist Med 10:567–568, 1941

    Google Scholar 

  94. Meis JEGM, Verhave JP, Jap PHK, Meuwissen JHETh: An ultrastructural study on the role of Küpffer cells in the process of infection by Plasmodium berghei sporozoites in rats. Parasitology 86:231–242, 1983

    Article  PubMed  Google Scholar 

  95. Hollingdale MR: Malaria and the liver. Hepatology 5:327–335, 1985

    Article  PubMed  CAS  Google Scholar 

  96. Coatney GR: Relapse in malaria—an enigma. J Parasitol 62:3–9, 1976

    Article  PubMed  CAS  Google Scholar 

  97. Schmidt LH: Compatibility of relapse patterns of Plasmodium cynomolgi infections in rhesus monkeys with continuous cyclical development and hypnozoite concepts of relapse. Am J Trop Med Hyg 35:1077–1099, 1986

    PubMed  CAS  Google Scholar 

  98. Krotoski WA: Discovery of the hypozoite and a new theory of malarial relapse. Trans Roy Soc Trop Med Hyg 79:1–11, 1985

    Article  PubMed  CAS  Google Scholar 

  99. Dvorak, JSA, Miller LH, Whitehouse WC, et al.: Invasion of erythrocytes by malaria merozoites. Science 187:748–750, 1975

    Article  PubMed  CAS  Google Scholar 

  100. Aikawa M, Miller LH, Johnson J, et al.: Erythrocyte entry by malaria parasites, a moving junction between erythrocyte and parasite J. Cell Biol. 77:72–82, 1978

    Article  PubMed  CAS  Google Scholar 

  101. Garvey G, Neu HC, Katz M: Transfusion-induced malaria after open heart surgery. N.Y. State J. Med. 75:602–603, 1975

    PubMed  CAS  Google Scholar 

  102. Covell G. Congential malaria Trop. Dis. Bull. 47:1147–1167 1950

    CAS  Google Scholar 

  103. Coatney GR, Collins WE, Warren N, et al.: The primate malarias. U.S. Department of Health, Education and Welfare, Bethesda, Maryland, 1971

    Google Scholar 

  104. World Health Organization: Severe and complicated Malaria. Trans Roy Soc Trop Med Hyg 80:(suppl) 1–50, 1986

    Article  Google Scholar 

  105. MacPherson GG, Warrell MJ, White NJ et al. Human cerebral malaria: a quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am J Path 119:385–401, 1985

    PubMed  CAS  Google Scholar 

  106. Udeinya I, Schmidt JA, Aikawa M, Miller LH, Green I: Falciparum malaria-infected erythrocytes bind to cultured human endothelial cells. Science 213:555–557, 1981

    Article  PubMed  CAS  Google Scholar 

  107. Looareesuwan S, Ho M, Wattanagoon Y, White NJ et al. Dynamic alteration in splenic function during acute falciparum malaria. N Eng J Med 317:675–679, 1987

    Article  CAS  Google Scholar 

  108. Greenwood BM, Fakunle YM: The tropical splenomegaly syndrome. A review of its pathogenesis. In: The role of the spleen in the immunology of parasitic diseases. Tropical Disease Research Series. No. 1. Basel, Schwabe & Co., 1979, pp. 229–244

    Google Scholar 

  109. Bruce-Chwatt ZJ: Malaria. In: Jelliffe D.B., Stanfield JP (eds): Diseases of children in the subtropics and tropics, 3rd Edition, London. Edward Arnold, 1978, pp. 827–856.

    Google Scholar 

  110. Whittle HC, Brown J, Marsh K, Greenwood BM et al: T-cell control of Epstein-Barr virus-infected B cells is lost during P. falciparum malaria. Nature 312:449–450, 1984

    Article  PubMed  CAS  Google Scholar 

  111. Allison, AC: Protection afforded by sickle-cell trait against subtertion malarial infection. Br. Med. J. 1:290–294, 1954

    Article  PubMed  CAS  Google Scholar 

  112. Dean J, Schecter AN: Sickle-cell anemia: Molecular and cellular basis of therapeutic approaches (First of three parts) N Eng J Med 296:752–763, 1978

    Article  Google Scholar 

  113. Dean J, Schecter AN: Sickle-cell anemia: Molecular and cellular basis of therapeutic approaches (Second of three parts) N Eng J Med 299:804–811, 1978

    Article  CAS  Google Scholar 

  114. Dean J, Schecter AN: Sickle-cell anemia: Molecular and cellular basis of therapeutic approaches (Third of three parts) N Eng J Med 299:863–870, 1978

    Article  CAS  Google Scholar 

  115. Friedman, MJ: Ultrastructural damage to the malaria parasite in the sickled cell. J. Protozool. 26:195–199, 1979.

    PubMed  CAS  Google Scholar 

  116. Friedman MJ, Roth EF, Nagel RL, et al. Plosmodium falciparum: Physiological interactions with human sickle cells. Exp. Parasital. 47:73–80 1979

    Article  CAS  Google Scholar 

  117. Bunn HE, Forget BG: In Hemoglobin: Molecular, Genetic, and Clinical Aspects. Philadelphia, W.B. Saunders Co., 1986 pp 690

    Google Scholar 

  118. Londner MV, Rosen G, Sintov A, Spira OT: The feasibility of a DOT enzyme-linked immunosorbent assay (DOT-ELISA) for the diagnosis of Plasmodium falciparum antigens and antibodies. Am J Trop Med Hyg 36:240–245, 1987

    PubMed  CAS  Google Scholar 

  119. Collins FH, Zavala F, Graves PM, Cochrane AH, et al.: First field trial of an immuno-radiometric assay for the detection of malarial sporozoites in mosquitoes. Am J Trop Med Hyg 33:538–542, 1984

    PubMed  CAS  Google Scholar 

  120. Beier JC, Perkens PV, Wirtz RA, Whitmire RE et al.: Field evaluation of an enzyme-linked immunosorbent assay (ELISA) for Plasmodium falciparum sporozoite detection in anopheline mosquitoes from Kenya. Am J Trop Med Hyg 36:459–468, 1987

    PubMed  CAS  Google Scholar 

  121. Bruce-Chwatt LJ: From Laveran’s discovery to DNA probes: New trends in diagnosis of malaria. Lancet 92:1509–1511, 1988

    Google Scholar 

  122. Miller KD, Lobel HO, Satriale RF, Kuritsky JN et al.: Severe cutaneous reactions among American travelers using Pyramethamine-Sulfadoxine (Fansidar ®) for malaria prophylaxis Am J Trop Med Hyg 35:451–458, 1986

    PubMed  CAS  Google Scholar 

  123. Miller LH, Howard RJ, Carter R, Good MF et al.: Research toward malaria vaccines. Science 234:1349–1356, 1986

    Article  PubMed  CAS  Google Scholar 

  124. Nussenzweig RS, Nussenzweig V: Development of a malaria vaccine based on the structure of the circumsporozoite protein. In: WA Siddiqui (ed) Proceedings of the Asia and Pacific Conference on Malaria: Practical Considerations on Malaria Vaccines and Clinical Trials. Honolulu, JA Burns School of Medicine, U of Hawaii, 1985. pp. 143–158

    Google Scholar 

  125. Ballow WR, Hoffman SL, Sherwood MR, Hollingdale MR et al.: Safety and efficacy of a recombinent DNA Plasmodium falciparum sporozoite vaccine. Lancet 1:1277–1281, 1987

    Google Scholar 

  126. Herrington DA, Clyde DF, Hosonsky M, Cortesia M et al.: Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites. Nature 328:257–259, 1987

    Article  PubMed  CAS  Google Scholar 

  127. Marsh K, Howard RJ: Andgens induced on erythrocytes by P. falciparum: expression of diverse and converged determinants. Science 231:150–153, 1986

    Article  PubMed  CAS  Google Scholar 

  128. Howard RJ: Antigenic variation of bloodstage malaria parasites. Phil Trans Roy Soc London (B) 307:141–158, 1984

    Article  CAS  Google Scholar 

  129. Carter R, Miller LH, Rener J, Kaushal DC et al.: Target antigens in malaria transmission blocking immunity. Phil Trans R Soc Lond (B) 307:201–213, 1984

    Article  CAS  Google Scholar 

  130. Schiffler RJ, Mansur GP, Navin TR et al.: Indigenous Chagas’ disease (American trypanosomiasis) in California. JAMA 251:2983–2984, 1984

    Article  PubMed  CAS  Google Scholar 

  131. Woody NC, Woody HB: American trypanosomiasis (Chagas’ disease): First indigenous case in the U.S.A. JAMA 159:676, 1955

    Article  CAS  Google Scholar 

  132. Koberle F: Chagas’ disease and Chagas’ syndromes: The pathology of American trypanosomiasis. In Dawes B (ed): Advances in Parasitology. New York, Academic Press, Vol 6. 1968, pp 63–116

    Google Scholar 

  133. Brener Z: Present status of chemotherapy and chemoprophylaxis of human trypanosomiasis in the western hemisphere. Pharmacol Ther 7:71–90, 1979

    Article  PubMed  CAS  Google Scholar 

  134. Schmuñis GA: Chagas’ Disease and Blood Transfusion in: Infection, Immunity and Blood Transfusion. Alan R. Liss, Inc. pp. 127–145 1985.

    Google Scholar 

  135. Goldsmith RS, Zarte R, Kagan I, et al.: El potencial de la transmission en la enfermedad de Chagas por transfusion sanguinea: Hallazgoz serologicos entre donadores en el estade de Oaxaca. Sal Pub Mex 20:439–444, 1978

    CAS  Google Scholar 

  136. Chagas C: Nova trypanozomiaze humana. Estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen, n. spec, ajente etiolojico de nova entidade morbida de homem. Memorias Inst Oswaldo Cruz 1:159–218, 1909

    Article  Google Scholar 

  137. Brumpt AJE: Le Trypanosoma cruzi evolue chez Conorhinus megistus. Cimex lectularius, Cimex boueti et Ornithodorus moubata. Cycle evolutif de ce parasite. Bull Soc Pathol Exot 5:360–364, 1912

    Google Scholar 

  138. Vianna G: Contribuicao para o estudo da anatomia patolojica da “Moletia de Carlos Chagas” (Esquizotripanoze humana ou tireodite parazitaria). Memorias Inst Oswaldo Cruz 3:276–294, 1916

    Google Scholar 

  139. McGreevy PB, Marsden PD: American Trypanosomiasis and Leishmaniasis in: Chemotherapy of Parasitic diseases. (Campbell WC and Rew RS, eds) Plenum Press, New York and London, pp. 115–128, 1986

    Google Scholar 

  140. Dias JCP: Control of Chagas’ disease in Brazil. Parasit Today 3:336–341, 1987

    Article  CAS  Google Scholar 

  141. Brener Z: Why vaccines do not work in Chagas’ Disease. Parasit Today 2:196–197, 1986

    Article  CAS  Google Scholar 

  142. Atkins J: The Navy Surgeon, or Practical System of Surgery with a Dissertation on Cold and Hot Mineral Springs and Physical Observations on the Coast of Guiney. London, J Hodges, 1742

    Google Scholar 

  143. Bruce D: Preliminary Report of the Tsetse Fly Disease or Nagana in Zululand. Durban, Bennet and Davis, 1895

    Google Scholar 

  144. Forde RM: Some clinical notes on a European patient in whose blood a trypanosome was observed. J Trop Med 5:261–263, 1902

    Google Scholar 

  145. Stephens JWW, Fantham HB: On the peculiar morphology of a trypanosome from a case of sleeping sickness and the possibility of its being a new species (T. rhodesiense). Proc R Soc Lond S [Biol] 83:23–33, 1910

    Google Scholar 

  146. Kinghorn A, Yorke W: On the transmission of human trypanosomes by Glossina morsitans westw.; and on the occurrence of human trypanosomes in game. Ann Trop Med Parasitol 6:1–23, 1912

    Google Scholar 

  147. Bertram BCR: Sleeping sickness survey in the Serengeti Area (Tanzania) (1971). III. Discussion of the relevance of the trypanosome survey to the biology of the large mammals in the Serengeti. Acta Trop 30:36–48, 1973

    PubMed  CAS  Google Scholar 

  148. Cross GAM: Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of T. brucei. Parasitology 71:393–417, 1975

    Article  PubMed  CAS  Google Scholar 

  149. Gray AR: Antigenic variation in a strain of Trypanosoma brucei transmitted by Glossina morsitans and G. palpalis. J Gen Microbiol 41:195–214, 1965

    PubMed  CAS  Google Scholar 

  150. Buck GA, Eisen H: Regulation of the genes encoding variable surface antigens in African trypanosomes. ASM News 51:118–122, 1985

    Google Scholar 

  151. Winterbottom TM: An Account of the Native Africans in the Neighborhood of Sierra Leone, Vol. 2. London, J. Hatchard and J. Mawman, 1803

    Google Scholar 

  152. Voller A, Bidwell DE, Bartlett A, et al.: A comparison of isotopic and enzyme-immonoassays for tropical parasitic diseases. Trans R Soc Trop Med Hyg 71:431–437, 1977

    Article  PubMed  CAS  Google Scholar 

  153. Bocchi CJ, Nathan HC, Hutner SH, et al.: Polyamine metabolism: a potential therapeutic target in trypanosomes. Science 210:332–334, 1980

    Article  Google Scholar 

  154. Schechter PJ, Sjoerdsma H: Difluoromethyloornithine in the treatment of African trypanosomiasis. Parasit Today 2:223–224, 1986

    Article  CAS  Google Scholar 

  155. Phelps RJ, Vale GA: Studies on populations of Glossina morsitans morsitans and G. pallidipe (Diptera: Glossinidae) in Rhodesia. J Appl Ecol 15:743–760, 1978

    Article  Google Scholar 

  156. Wirth D, McMahon-Pratt D: Rapid identification of Leishmania species by specific hybridization of kinetoplast DNA in cutaneous lesions. Proc Nat Acad Sci USA 79:6999–7003, 1982

    Article  PubMed  CAS  Google Scholar 

  157. Pappas MG, Hajkowski R, Diggs CL, et al.: Disposable nitrocellular filtration plates simplify the Dot-ELISA for serodiagnosis of visceral leishmaniasis. Trans Roy Soc Trop Med Hyg 79:136, 1985

    Article  PubMed  CAS  Google Scholar 

  158. Russell A: Of the mal d’Aleppo. In Millar A (ed): Natural History of Aleppo and Parts Adjacent. London. 1856, pp 262–266

    Google Scholar 

  159. Cunningham DD: On the presence of peculiar parasitic organisms in the tissue of a specimen of Delhi boil. Sci Mem Med Officers Army India 1:21–31, 1885

    Google Scholar 

  160. Adler S, Theodor O: The transmission of Leishmania tropica from artificially infected sandflies to man. Ann Trop Med Parasitol 21:89–110, 1927

    Google Scholar 

  161. Sergeiev PG, Beislehem RI, Moshkovski SD, et al.: Massive vaccination against cutaneous leishmaniasis. Med Parasitol Parazit Bolezni 39:541–551, 1970

    Google Scholar 

  162. Carini A: Leishmaniose de la muqueuse rhino-buccopharyngee. Bull Soc Pathol Exot 4:289–291, 1911

    Google Scholar 

  163. Vianna G: Tratamento da leishmaniose tegumentar por injecoes intravenososas de tartaro emetico. Ann do 7 Congresso Brasileiro de Medicina e Cirurgia. 4:426–428, 1912

    Google Scholar 

  164. Kligler IJ: The cultural and serological relationship of leishmania. Trans R Soc Trop Med Hyg 19:330–335, 1916

    Article  Google Scholar 

  165. Noguchi H: Comparative studies on herpetomonads and leishmaniasis. II. Differentiation of the organisms by serological reactions and fermentation tests. J Exp Med 44:305–314, 1929

    Google Scholar 

  166. Leishman WB: On the possibihty of occurrence of trypanosomiasis in India. Br Med J 1:1252–1254, 1903

    Article  Google Scholar 

  167. Donovan C: On the possibility of occurrence of trypanosomiasis in India. Br Med J 2:79, 1903

    Article  Google Scholar 

  168. Cunningham DD: On the presence of peculiar parasitic organisms in the tissue of a specimen of Delhi boil. Sci Mem Med Officers Army India 1:21–31, 1885

    Google Scholar 

  169. Nicolle C: Nouvelles acquisitions sur Kala-azar: Cultures; inoculation au chien; etiologie. CR Hebdom Sci 146:498–499, 1908

    Google Scholar 

  170. Swaminath CS, Shortt HE, Anderson LAP: Transmission of Indian kala-zar to man by the bites of Phlebotomus argentipes. Ann Brun Indian J Med Res 30:473–477, 1942

    Google Scholar 

  171. Badaro R, Jones TC, Cawalho EM, et al.: New perspectives on a subclinical form of visceral leishmaniasis. J Infect Dis 154:1003–1011, 1986

    Article  PubMed  CAS  Google Scholar 

  172. Dutz W: Pneumocystis carinii pneumonia. Pathol Annu 5:309–341, 1970

    PubMed  CAS  Google Scholar 

  173. Chagas C: Novo trypanomaiazaia human. Mem Inst Oswaldo Cruz 1:159, 1909

    Article  Google Scholar 

  174. Delanoë P, Delanoë M: Sur les rapports des kystes de carinii du pneumon des rats avec le trypanosoma Lewisii. C R Acad Sci 155:658, 1912

    Google Scholar 

  175. Vossen MEMH, Beckers PJA, Meuwissen JHETh, et al: Developmental biology of Pneumocystis carinii, an alternative view on the life cycle of the parasite. Z Parasitenkd 55:101–118, 1978

    Article  PubMed  CAS  Google Scholar 

  176. Masur H, Jones TC: The interaction in vitro of Pneumocystis carinii with macrophages and L-cells. J Exp Med 147:157–170, 1978

    Article  PubMed  CAS  Google Scholar 

  177. Varva JK, Kucera K: Pneumocystis carinii Delanoë, its ultrastructure and intrastructural affinities. J Protozool 17:463–483, 1970

    Google Scholar 

  178. Pifer LL, Hughes WT, Murphy MJ Jr: Propagation of Pneumocystis carinii in vitro. Pediatr Res 11:305–316, 1977

    Article  PubMed  CAS  Google Scholar 

  179. Walzer PD, Schultz MG, Western KA, et al.: Pneumocystis carinii pneumonia and primary immunodeficiency diseases of infancy and childhood. J Pediatr 82:416–422, 1973

    Article  PubMed  CAS  Google Scholar 

  180. Brazinsky JH, Phillips JE: Pneumocystis pneumonia transmission between patients with lymphoma. JAMA 209:1527–1529, 1969

    Article  PubMed  CAS  Google Scholar 

  181. Koltay M, Illyes M: A study of immunoglobulin in the blood serum of infants with interstitial plasma cellular pneumonia. Acta Paediat Scand 55:489–496, 1969

    Article  Google Scholar 

  182. Grimes MM, La Pook JD, Bar MH, et al.: Disseminated Pneumocystis carinii infection in a patient with aquired immunodeficiency syndrome. Human Path 18:307–308, 1987

    Article  CAS  Google Scholar 

  183. Schinella RA, Breda SD, Hammerschlag PE: Otic infection due to Pneumocystis carinii in an apparently healthy man with antibody to the human immunodeficiency virus. Assoc Int Med 106:399–400, 1987

    CAS  Google Scholar 

  184. Wharton JM, Coleman DL, Wolfsy CB, et al.: Trimethoprim sulfamethoxyazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome Ann Int Med 105:37–44, 1986

    PubMed  CAS  Google Scholar 

  185. Hughs WT, Rivera GK, Schell MJ et al.: Successful intermittent chemoprophylaxis for Pneumocystis carinii pneumonitis. N Eng J Med 316:1627–1632, 1987

    Article  Google Scholar 

  186. Smith RP, Evans AT, Popovsky M, et al.: Transfusion-acquired babesiosis and failure of antibiotic treatment. JAMA 256:2726–2727, 1986

    Article  PubMed  CAS  Google Scholar 

  187. Smith T, Kilboume PL: Investigations into the nature, causation and prevention of Texas or south cattle fever. USDA Bureau Anim Indust Bull 1:1–301, 1893

    Google Scholar 

  188. Skrabalo Z, Deanovic Z: Piroplasmosis in man. Documenta Med Geogr Trop 9:11–16, 1957

    CAS  Google Scholar 

  189. Gamham PCC: Human babesiosis: European aspects. Trans R Soc Trop Med Hyg 74:153–156, 1980

    Article  Google Scholar 

  190. Hoare CA: Comparative aspects of human babesiosis. Trans R Soc Trop Med Hyg 74:143–148, 1980

    Article  PubMed  CAS  Google Scholar 

  191. Williams H: Human babesiosis. Trans R Soc Trop Med Hyg 74:157–158, 1980

    Article  PubMed  CAS  Google Scholar 

  192. Ruebush TK II: Human babesiosis in North America. Trans R Soc Trop Med Hyg 74:149–152, 1980

    Article  PubMed  Google Scholar 

  193. Chisolm ES, Ruebush TK II, Sulzer AJ, et al.: Babesia microti infections in man: Evaluation of indirect immunofluorescent antibody test. Am J Trop Med Hyg 27:14–19, 1978

    Google Scholar 

  194. Miller LH, Neva FA, Gill F: Failure of chloroquine in human babesiosis (Babesia microti). Ann Intern Med 88:200–202, 1978

    PubMed  CAS  Google Scholar 

  195. Brendt AB, Weinstein WM, Cohen S: Treatment of babesiosis in asplenic patients. JAMA 245:1938–1939, 1981

    Article  Google Scholar 

  196. Dammin GJ, Spielman A, Benach JL, et al.: The rising incidence of clinical Babesia microti infection. Hum Pathol 12:398–400, 1981

    Article  PubMed  CAS  Google Scholar 

  197. Healy GR, Spielman A, Gleason N: Human babesiosis: Reservoir of infection on Nantucket Island. Science 192:479–480, 1976

    Article  PubMed  CAS  Google Scholar 

  198. Spielman A: Human babesiosis on Nantucket Island: Transmission by nymphal Ixodes ticks. Am J Trop Med Hyg 25:784–787, 1976

    PubMed  CAS  Google Scholar 

  199. Spielman A, Clifford C, Piesman J, et al.: Human babesiosis on Nantucket Island, U.S.A.: Description of the vector Ixodes (Ixodes) dammini, n. sp. (Acarina: Ixodidae). J Med Entomol 15:218–234, 1979

    PubMed  CAS  Google Scholar 

  200. Spencer MJ, Garcia LS, Chapin MR: Dientamoeba fragilis an intestinal pathogen in children? Am J Dis Child 133:390–393, 1979

    PubMed  CAS  Google Scholar 

  201. Dwyer DM: Analysis of the antigenic relationships among Trichomonas, Histomonas, Dientamoeba, and Entamoeba: I. Quantitative fluorescent antibody methods. J Protozool 19:316–325, 1972

    PubMed  CAS  Google Scholar 

  202. Carter RF: Primary amoebic meningoencephalitis: Clinical, pathological, and epidemiological features of six fatal cases. J Pathol Bacteriol 96:1–25, 1968

    Article  PubMed  CAS  Google Scholar 

  203. Culbertson CG: The pathogenicity of soil amebas. Annu Rev Microbiol 25:231–254, 1971

    Article  PubMed  CAS  Google Scholar 

  204. Carter RF: Primary amoebic meningo-encephalitis—an appraisal of present knowledge. Trans R Soc Trop Med Hyg 66:193–213, 1972

    Article  PubMed  CAS  Google Scholar 

  205. Ma P, Willaert K, Juechter KB, et al.: A case of keratitis due to Acanthamoeba in New York, New York and features of 10 cases. J Infect Dis 143:662–667, 1981

    Article  PubMed  CAS  Google Scholar 

  206. Stehr-Green JK, Bailey TM, Brandt FH, et al.: Acanthamoeba keratitis in soft contact lens wearers. A case control study. JAMA 258:57–60, 1987

    Article  PubMed  CAS  Google Scholar 

  207. Zierdt, CH: Blastocystis hominis, a protozoan parasite and intestinal pathogen of human beings. Coin Micro Newsletter 5:57–59, 1983

    Article  Google Scholar 

  208. Vanaratta B, Adamson D, Mullican K: Blastocystis hominis infection presenting as recurring diarrhea. Ann Int Med 102:495–496, 1986

    Google Scholar 

  209. Markell EK, Udkow MP: Blastocystis Hominis: Pathogen or fellow fraveler? Am J Trop Med Hyg 35:1023–1026, 1986

    PubMed  CAS  Google Scholar 

  210. Honigberg BM: Trichomonads of importance in human medicine. In Kreier JP (ed): Parasitic Protozoa, Vol 2. New York, Academic Press, 1978, pp 275–454

    Google Scholar 

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Katz, M., Despommier, D.D., Gwadz, R.W. (1989). The Protozoa. In: Parasitic Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-0327-5_4

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