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Alternative Mechanisms of Multidrug Resistance in Cancer pp 173–190Cite as

The Contribution of Protein Kinase C to Multiple Drug Resistance in Cancer

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Abstract

The use of combination chemotherapy in cancer treatment to address the heterogeneous nature of tumor cell populations has long been accepted as a standard practice. The acquisition of resistance to chemotherapeutic agents by malignant tumor cell populations during cancer therapy presents a formidable barrier to efforts underway to successfully manage the disease (Gottesman and Pastan, 1993). This has been the driving force behind the search for agents that can reverse clinical drug resistance in cancer therapy. In recent years, the heterogeneous nature of drug resistance mechanisms acquired by cancer cell populations during chemotherapy and innate in certain untreated cancers has become evident (Gottesman and Pastan, 1993; Fan et al., 1994; Kellen, 1994; Beck, 1989). For example, drug resistance mechanisms in cancer cell populations have been found to involve to various extents glutathione-S-transferases (Chapter 2), the multidrug resistance-associated protein (MRP) (Chapter 5), topoisomerases (Chapters 7 and 8), the oncogene Bcl-2 (Chapter 12), the drug-efflux pump P-glycoprotein (Endicott and Ling, 1989), and protein kinase C (PKC). This suggests that a combination of agents that antagonize distinct drug resistance mechanisms may be required to reverse clinical drug resistance in cancer and improve the ultimate therapeutic outcome for the patient.

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Authors
  1. Catherine A. O’Brian
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  2. Nancy E. Ward
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  3. Krishna P. Gupta
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  4. Karen R. Gravitt
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Editor information

Editors and Affiliations

  1. Sunnybrook Health Science Center, University of Toronto, Toronto, Canada, M4N 3M5

    John A. Kellen

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© 1995 Birkhäuser Boston

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O’Brian, C.A., Ward, N.E., Gupta, K.P., Gravitt, K.R. (1995). The Contribution of Protein Kinase C to Multiple Drug Resistance in Cancer. In: Kellen, J.A. (eds) Alternative Mechanisms of Multidrug Resistance in Cancer. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9852-7_9

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  • DOI: https://doi.org/10.1007/978-1-4615-9852-7_9

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4615-9854-1

  • Online ISBN: 978-1-4615-9852-7

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