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Insights into the Genomic Mechanism of Action of 1,25-Dihydroxyvitamin D3

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Book cover Steroid Hormone Receptors: Basic and Clinical Aspects

Part of the book series: Hormones in Health and Disease ((HHD))

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Abstract

Steroid, thyroid, and vitamin hormones are known to exert profound regulatory control over complex gene networks. Many, if not all, of these actions occur at the level of the cellular genome (O’Malley, 1992; Yamamoto, 1985). The products of these modulated genes control processes essential to cellular growth and differentiation as well as influence mechanisms integral to the maintenance of intracellular and extracellular homeostasis. The actions of these signals are mediated by unique intracellular receptors (Jensen et al, 1968; Jensen and DeSombre, 1972). Indeed, the presence of these receptor proteins in cells and tissues represents a principal determinant of response to a particular hormone. These soluble signal-transducing proteins are members of an enlarging gene family of latent transcription factors that acquire unique gene regulating capacities upon activation by their respective hormonal ligands (Evans, 1988). While hormone interaction has been well characterized, the events that follow association of the ligand with its receptor remain less well understood.

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Authors and Affiliations

  1. Department of Biochemistry, Ligand Pharmaceuticals, Inc., USA

    J. Wesley Pike

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  1. J. Wesley Pike
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Editors and Affiliations

  1. Department of Biological Sciences, Oakland University, Rochester, Michigan, 48309-4401, USA

    V. K. Moudgil

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© 1994 Birkhäuser Boston

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Pike, J.W. (1994). Insights into the Genomic Mechanism of Action of 1,25-Dihydroxyvitamin D3 . In: Moudgil, V.K. (eds) Steroid Hormone Receptors: Basic and Clinical Aspects. Hormones in Health and Disease. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9849-7_6

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  • DOI: https://doi.org/10.1007/978-1-4615-9849-7_6

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4615-9851-0

  • Online ISBN: 978-1-4615-9849-7

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