Abstract
The Ah locus was first described as a difference among inbred strains of mice when challenged with polycyclic aromatic hydrocarbons. Schmid et al (1) noted that when 7,12-dimethylbenzanthracene was applied to the skin of C57BL/6J they developed skin ulceration, while AKR/J did not. Nebert et al (2) noted that intraperitoneal administration of 3-methylcholanthrene (3-MC) induced hepatic cytochrome P-450IA1 and the associated monooxygenase activity—aryl hydrocarbon hydroxylase (AHH) in C57BL/6 mice but not in DBA/2 mice. In crosses and backcrosses between these strains, the trait of aromatic hydrocarbon responsiveness (hence the Ah locus) is inherited in a simple autosomal dominant mode.
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© 1994 Birkhäuser Boston
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Poland, A., Bradfield, C. (1994). The Ah Locus: A Review. In: Moudgil, V.K. (eds) Steroid Hormone Receptors: Basic and Clinical Aspects. Hormones in Health and Disease. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9849-7_20
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DOI: https://doi.org/10.1007/978-1-4615-9849-7_20
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