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Phosphorylation and Progesterone Receptor Function

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Steroid Hormone Receptors: Basic and Clinical Aspects

Part of the book series: Hormones in Health and Disease ((HHD))

Abstract

The progesterone receptor is a member of a superfamily of ligand activated transcription factors which includes the steroid receptors, thyroid hormone, retinoic acid and vitamin D receptors as well as a large number of proteins which are termed orphans because their ligands and/or their functions are unknown (Evans,1988; Wang et al, 1989). A variety of studies have shown that phosphorylation/dephosphorylation plays a major role in the regulation of the activity of numerous transcription factors. Phosphorylation can alter DNA binding, either by enhancing or inhibiting the activity, by changing DNA binding specificity or by altering interactions with other transcription factors (Englander et al, 1991; Prywes et al, 1988; Raychaudri et al, 1989; Boyle et al, 1991). In addition, phosphorylation is often important for transcriptional activation of the factors (Binetruy et al, 1991; Jackson et al, 1991). Moreover, transcription factors are frequently multiply phosphorylated and these phosphorylations may play different roles (Barber and Verma, 1987; Boyle et al, 1991). In some cases, both specific phosphorylations as well as specific dephosphorylations are required for full activity (Boyle et al, 1991).

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Author information

Authors and Affiliations

  1. Department of Cell Biology, Baylor College of Medicine, USA

    Nancy L. Weigel

  2. Istituto di Endocrinologia, Milano, Italy

    Angelo Poletti

  3. Department of Pathology, University of Colorado Health Science Center, USA

    Candace A. Beck & Dean P. Edwards

  4. Department of Biological Sciences, St John’s University, USA

    Timothy H. Carter

  5. Texas Biotechnology Corp., Houston, Texas, USA

    Larry A. Denner

Authors
  1. Nancy L. Weigel
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  2. Angelo Poletti
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  3. Candace A. Beck
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  4. Dean P. Edwards
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  5. Timothy H. Carter
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  6. Larry A. Denner
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Editor information

Editors and Affiliations

  1. Department of Biological Sciences, Oakland University, Rochester, Michigan, 48309-4401, USA

    V. K. Moudgil

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© 1994 Birkhäuser Boston

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Weigel, N.L., Poletti, A., Beck, C.A., Edwards, D.P., Carter, T.H., Denner, L.A. (1994). Phosphorylation and Progesterone Receptor Function. In: Moudgil, V.K. (eds) Steroid Hormone Receptors: Basic and Clinical Aspects. Hormones in Health and Disease. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9849-7_12

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  • DOI: https://doi.org/10.1007/978-1-4615-9849-7_12

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4615-9851-0

  • Online ISBN: 978-1-4615-9849-7

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