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Role of Oxygen Radicals in Central Nervous System Trauma

  • Chapter
Oxygen Free Radicals in Tissue Damage

Abstract

There is now extensive experimental support for the early occurrence and pathophysiological importance of oxygen radical formation and cell membrane lipid peroxidation in the injured nervous system (Braughler and Hall, 1989; Demopoulos et al., 1980; Hall and Braughler, 1986; Kontos and Povlishock, 1986). The radical-initiated peroxidation of neuronal, glial, and vascular cell membranes and myelin is catalyzed by free iron released from hemoglobin, transferrin, and ferritin by either lowered tissue pH or oxygen radicals. If unchecked, lipid peroxidation is a geometrically progressing process that will spread over the surface of the cell membrane causing impairment to phospholipid-dependent enzymes, disruption of ionic gradients and, if severe enough, membrane lysis.

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Authors
  1. Edward D. Hall
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Editors and Affiliations

  1. Dept. of Physiology, University of Kansas Medical Ctr., Kansas City, KS, 66160-7401, USA

    Merrill Tarr

  2. Ralph L. Smith Research Center, University of Kansas Medical Ctr., Kansas City, KS, 66160-7401, USA

    Fred Samson

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© 1993 Springer Science+Business Media New York

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Hall, E.D. (1993). Role of Oxygen Radicals in Central Nervous System Trauma. In: Tarr, M., Samson, F. (eds) Oxygen Free Radicals in Tissue Damage. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4615-9840-4_9

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  • DOI: https://doi.org/10.1007/978-1-4615-9840-4_9

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4615-9842-8

  • Online ISBN: 978-1-4615-9840-4

  • eBook Packages: Springer Book Archive

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