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Contributions of the Physical Properties of Neuroprotective Agents to their Efficacy as Inhibitors of Lipid Peroxidation

  • Chapter
Oxygen Free Radicals in Tissue Damage

Abstract

The chemistry and role of oxygen radicals and lipid peroxidation in brain damage has been extensively reviewed (Aust et al., 1985; Halliwell and Gutteridge, 1989; Siesjo et al., 1989). Collectively, the literature implicates oxygen radicals and the process of lipid peroxidation in central nervous system (CNS) tissue damage resulting from head and spinal cord injury, trauma, inflammation, and ischemic cerebrovascular disorders (Braughler and Hall, 1989). A causative role for oxygen radicals has also been suggested for other human diseases including cancer, multiple sclerosis, Parkinson’s disease, autoimmune diseases, senile dementia and the aging process (Gutteridge, 1987), and atherosclerosis (Henning and Chow, 1988; Henry, 1991). Accordingly, current drug research includes design and development of neuroprotective agents with appropriate antioxidant chemistry.

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Authors
  1. Kenneth L. Audus
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Editors and Affiliations

  1. Dept. of Physiology, University of Kansas Medical Ctr., Kansas City, KS, 66160-7401, USA

    Merrill Tarr

  2. Ralph L. Smith Research Center, University of Kansas Medical Ctr., Kansas City, KS, 66160-7401, USA

    Fred Samson

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© 1993 Springer Science+Business Media New York

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Audus, K.L. (1993). Contributions of the Physical Properties of Neuroprotective Agents to their Efficacy as Inhibitors of Lipid Peroxidation. In: Tarr, M., Samson, F. (eds) Oxygen Free Radicals in Tissue Damage. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4615-9840-4_11

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  • DOI: https://doi.org/10.1007/978-1-4615-9840-4_11

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4615-9842-8

  • Online ISBN: 978-1-4615-9840-4

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