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Getting Along With Oxygen

  • Chapter
Oxygen Free Radicals in Tissue Damage

Abstract

The spin restriction predisposes dioxygen to a univalent pathway of reduction. Superoxide (O -2 ), the first intermediate encountered on this univalent pathway, is consequently a commonly encountered product of dioxygen reduction. The finding that O -2 is produced by some enzymes and is efficiently scavenged by others (McCord and Fridovich, 1968, 1969) led to the view that O -2 is an agent of oxygen toxicity. In this view the superoxide dismutases (SODs), which catalytically scavenge O -2 , serve a defensive role (McCord et al., 1971), much as do catalases vís a vís H2O2. Given the early association of O -2 with radiation chemistry and its extensive study by pulse radiolysis (Czapski, 1971), the biological relevance of O -2 was not easily accepted.

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Authors
  1. Irwin Fridovich
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Editors and Affiliations

  1. Dept. of Physiology, University of Kansas Medical Ctr., Kansas City, KS, 66160-7401, USA

    Merrill Tarr

  2. Ralph L. Smith Research Center, University of Kansas Medical Ctr., Kansas City, KS, 66160-7401, USA

    Fred Samson

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© 1993 Springer Science+Business Media New York

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Fridovich, I. (1993). Getting Along With Oxygen. In: Tarr, M., Samson, F. (eds) Oxygen Free Radicals in Tissue Damage. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4615-9840-4_1

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  • DOI: https://doi.org/10.1007/978-1-4615-9840-4_1

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4615-9842-8

  • Online ISBN: 978-1-4615-9840-4

  • eBook Packages: Springer Book Archive

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