Abstract
Aspartame doses of 50 mg/kg and 100 mg/kg, given intraperitoneally, reduced 50% convulsion doses of lidocaine by 29.5% and 37.8%, respectively. These values are statistically significant. Latency time and recovery time were not significantly changed. Orally administered doses of aspartame up to 600 mg/kg did not change the 50% convulsion dose of lidocaine.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baird, H.W. (1983). Convulsive disorders. In Behrman, R.E., and Vaughan, V.C. (eds.), Textbook of pediatrics. 12th ed. Philadelphia: W.B. Saunders, pp. 1234.
Geddes, I.C. (1967). Metabolism of local anesthetic agents. Anesthesiol. Clin. 5:525–541.
Litchfield, J.T., and Wilcoxon, F. (1949). A simplified method of evaluating dose-effect experiments. J. Exp. Pharm. Ther. 96:90–113.
Stegink, L.D. (1984a). Aspartame and glutamate metabolism. In Stegink, L.D., and Filer, L.J. (eds.), Aspartame: physiology and biochemistry. New York: Marcel Dekker, pp. 47–75.
Stegink, L.D. (1984b). Aspartame metabolism in humans. In Stegink, L.D., and Filer, L.J. (eds.), Aspartame: physiology and biochemistry. New York: Marcel Dekker, pp. 509–553.
Yokogoshi, H., Roberts, C.H., Caballero, B., and Wurtman, R.J. (1984). Effects of aspartame and glucose administration on brain and plasma levels of large neutral amino acids and brain 5-hydroxyindoles. Am. J. Clin. Nutr. 40:1–7.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Birkhäuser Boston
About this chapter
Cite this chapter
Kim, K.C., Tasch, M.D., Kim, S.H. (1988). The Effect of Aspartame on 50% Convulsion Doses of Lidocaine. In: Wurtman, R.J., Ritter-Walker, E. (eds) Dietary Phenylalanine and Brain Function. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9821-3_14
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9821-3_14
Publisher Name: Birkhäuser Boston
Print ISBN: 978-1-4615-9823-7
Online ISBN: 978-1-4615-9821-3
eBook Packages: Springer Book Archive