Invertebrate Neuropeptides



Peptides are now recognised as by far the largest and most structurally diverse class of neuroculatory substances (Snyder, 1980; Iversen, 1983; Krieger, 1983). This is true not only for vertebrates (Krieger, 1983, listed 38 known brain peptides) but also for invertebrates (see Table 5.1). The realisation that peptides play an important role within the brain has come only recently, being largely a result of improved techniques for physically handling and chemically manipulating the tiny quantities of peptides characteristically present in nervous tissue. Of course, peptides have been studied for much longer than this in their role as neurohormones. Indeed it is true to say that we still know most about those neuropeptides (vasopressin is a vertebrate example) that have neurohormonal functions, many (if not all) of which also have modulatory or transmitter roles within the brain. However, it is now clear that neuropeptides also exist (e. g. substance P) that have no known function as circulating regulatory agents.


High Performance Liquid Chromatography Abdominal Ganglion Atrial Gland Corpus Cardiaca Adipokinetic Hormone 
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