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Lipid Metabolic Interactions in the Mother during Pregnancy and their Fetal Repercussions

  • Chapter
Endocrine and Biochemical Development of the Fetus and Neonate

Part of the book series: Reproductive Biology ((RBIO))

Abstract

Aside from the products of conception, maternal body weight increase during gestation corresponds to increased mass in certain maternal structures and a specific accumulation of fat, as shown both in human pregnancy (1) and in the rat (2–4). This fat accumulation occurs during the first part of gestation (2,4) and is related to both maternal hyper-phagia, since it is not found in food restricted (5,6) or food deprived rats (2,7), and enhanced lipogenesis and unmodified or even augmented extrahepatic lipoprotein lipase (8,9). The tendency to accumulate fat ceases during late gestation (1,2,4) because the maternal lipid metabolism changes to a catabolic condition as shown by the increased lipolysis (10, 11) and the reduced circulating triglycerides uptake by adipose tissue (12). The latter is a consequence of reduced adipose tissue lipoprotein lipase activity (4,13–15). These changes, together with the hepatic overproduction of triglycerides (16–18) and enhanced absorption of dietary lipids (19) boosts the circulating triglyceride concentration in the mother during late gestation (4,8,13,20–26).

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Authors and Affiliations

  1. Departamento de Bioquímica e Investigación, Universidad de Alcalá de Henares and Hospital Ramón y Cajal, 28034, Madrid, Spain

    Emilio Herrera, Miguel A. Lasunción, Diego Gómez-Coronado, Antonia Martín & Bartolomé Bonet

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  1. Emilio Herrera
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  2. Miguel A. Lasunción
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  3. Diego Gómez-Coronado
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  4. Antonia Martín
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  5. Bartolomé Bonet
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Editor information

Editors and Affiliations

  1. Universidad Autonoma de Madrid, Madrid, Spain

    José M. Cuezva

  2. C.S.I.C. Universidad Complutense de Madrid, Madrid, Spain

    Ana M. Pascual-Leone

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Mulchand S. Patel

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© 1990 Plenum Press, New York

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Herrera, E., Lasunción, M.A., Gómez-Coronado, D., Martín, A., Bonet, B. (1990). Lipid Metabolic Interactions in the Mother during Pregnancy and their Fetal Repercussions. In: Cuezva, J.M., Pascual-Leone, A.M., Patel, M.S. (eds) Endocrine and Biochemical Development of the Fetus and Neonate. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9567-0_23

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  • DOI: https://doi.org/10.1007/978-1-4615-9567-0_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9569-4

  • Online ISBN: 978-1-4615-9567-0

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