Abstract
The decline in overall protein synthesis and concomitant increase in specific protein synthesis during brain development indicate the existence of mechanisms which control qualitative and quantitative modulations in protein biosynthesis as a function of physiological need. The decrease in the rate of protein synthesis in mammalian brain tissue during neural development is measurable at several levels of neural complexity including in vivo, cortical slices and ce11-free systems. The aggregation of ribosomes forming polyribosomes also diminishes during brain development and an age-dependent decrease in the activity of protein initiation factors in rat brain has also been reported (1–3). These findings suggest that the control of protein synthesis during brain development may be exerted at the level of initiation.
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© 1990 Plenum Press, New York
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Salinas, M., Alcázar, A., Martín, M.E., Azuara, M., Fando, J.L. (1990). Regulation of Protein Synthesis during Brain Development. Role for Initiation Factor 2. In: Cuezva, J.M., Pascual-Leone, A.M., Patel, M.S. (eds) Endocrine and Biochemical Development of the Fetus and Neonate. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9567-0_22
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DOI: https://doi.org/10.1007/978-1-4615-9567-0_22
Publisher Name: Springer, Boston, MA
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