Abstract
During mammalian development an important aspect of cell metabolism is that related with the pathway of energy provision, because, in one way or another, the rest of metabolic pathways and cellular functions depend on an efficient supply of energy. It is in the mitochondria where energy is generated by the oxidation of cellular substrates into its useful form of ATP. Cells devoid of, or which contain a poorly developed mitochondria, rely on the less efficient anaerobic glycolysis for harnessing their ATP needs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
H.B. Burch, D.H. Lowry, A.M. Kuhlman, J. Skerjance, E.J. Diamant, S. R. Lowry and P.Von Dippe, Changes in patterns of enzymes of carbohydrate metabolism in the developing rat liver, J.Biol.Chem. 238: 2267 (1963).
F.A. Hommes, Energetic aspects of late fetal and neonatal metabolism, in: “Normal and Pathological Development of Energy Metabolism”, F.A. Hommes and C.J.Van den Berg, eds. Academic Press, London, pp. 1 (1975).
F.A. Hommes, G.P.B. Kraan and R. Berger, The regulation of ATP synthesis in fetal rat liver, Enzyme 1: 351 (1973).
E. Chico, J.S. Olavarria and I.Nunez de Castros, Crabtree effect induced by fructose in hepatocytes isolated from developing rats, Enzyme 24: 209 (1979).
R. Berger and F.A. Hommes, Regulation of pyruvate oxidation in mitochondria isolated from fetal and adult rat liver, Biochim. lBiophys.Acta. 314: 1 (1973).
H. P. Rohr, A. Wirz, L.C. Henning, V.N. Riede and L. Bianchi, Morphometric analysis of the rat liver cell in the perinatal period, Lab.Invest. 24: 128 (1971).
C.A. Lang and G. H. Herber, Quantitative comparison of the mitochondrial populations in the livers of newborn and weaning rats, Dev.Biol. 29: 176 (1972).
H. David, Quantitative and qualitative changes in the mitochondria in hepatocytes during postnatal development of male rats, Exp.Pathol. 17: 359 (1979).
J.R. Aprille, Perinatal development of mitochondria in rat liver, in: “Mitochondrial Physiology and Pathology”, G. Fiskum, ed., Van Nostrand Reinhold Co., New York, pp. 66 (1986).
J.K. Pollak and C.G. Duck-Chong, Changes in rat liver mitochondria and endoplasmic reticulum during development and differentiation, Enzyme 15: 139 (1973).
M. Hallman, Changes in mitochondrial respiratory chain proteins during perinatal development. Evidence of the importance of environmental oxygen tension, Biochim.Biophys. Acta 253: 360 (1971).
T. Nakazawa, K. Asami, H. Suzuki and O. Yukawa, Appearance of an energy conservation system in rat liver mitochondria during development, J.Biochem. 73: 397 (1973).
J.K. Pollak, The maturation of the inner membrane of fetal rat liver mitochondria, Biochem. J. 150: 477 (1975).
J.R. Aprille and G.K. Asimakis, Postnatal development of rat liver mitochondria: State 3 respiration, adenine nucleotide translocase activity, and the net accumulation of adenine nucleotides, Arch. Biochem.Biophys. 201: 564 (1980).
C. Valcarce, R.M. Navarrete, P. Encabo, E. Loeches, J. Satrustegui and J.M. Cuezva, Postnatal development of rat liver mitochondrial functions: The roles of protein synthesis and of adenine nucleotides, J.Biol.Chem. 263: 7767 (1988).
C. Valcarce, J.M. Cuezva and J.M. Medina, Increased gluconeogenesis in the rat at term gestation, Life Sciencies 37: 553 (1985).
C. Valcarce, J.M. Cuezva and J.M. Medina, Phosphoenolpyruvate carboxykinase activity in the kidney of pregnant rats during late gestation, Biochem.Soc.Trans. 12: 789 (1984).
J.M. Cuezva, C. Valcarce, M. Chamorro, A. Franco and F. Mayor, Alanine and actate as gluconeogenic substrates during late gestation, FEBS Lett. 194: 219 (1986).
P.C. Foster and E. Bailey, Changes in the activities of the enzymes of hepatic fatty acid oxidation during development of the rat, Biochem. J. 154: 49 (1976).
J. Girard and P. Ferré, Metabolic and hormonal changes around birth, in: “The Biochemical Development of the Fetus and Neonate”, C.T. Jones, ed., Elsevier Biomedical Press, Amsterdam, pp. 517 (1982).
F. Mayor and J.M. Cuezva, Hormonal and metabolic changes in the perinatal period, Biol.Neonate 48: 185 (1985).
J.K. Pollak and R. Sutton. The differentiation of animal mitochondria during development, Trends Biochem.Sei. 5: 23 (1980).
K.D. Garlid and A.D. Beavis, Evidence for the existence of an inner membrane anion channel in mitochondria, Biochim. Biophys. Acta 853: 187 (1986).
R. Sutton and J.K. Pollak, The increasing adenine nucleotide concentration of rat liver mitochondria during neonatal development, Differentiation 12: 15 (1978).
R. Hay, P. Bohni and S. Gasser. How mitochondria import protein, Biochim. Biophys.Acta 779: 65 (1984).
A. Tzagoloff and A.M. Myers, Genetics of mitochondrial biogenesis, Ann. Rev.Biochem. 55: 249 (1986).
D.E. Hale and J.R. Williamson, Developmental changes in the adenine nucleotide translocase in the guinea pig, J.Biol.Chem. 259: 8737 (1984).
L. Bagetto, D. C. Gautheron and C. Godinot, Effects of ATP on various steps controlling the rate of oxidative phosphorylation in newborn rat liver mitocondria, Arch. Biochem.Biophys. 232: 670 (1984).
N. Pfanner and W. Neupert, Transport of proteins into mitochondria: a potassium diffusion potential is able to drive the import of ADP/ATP carrier, EMBO J. 4: 2819 (1985).
Y. Kagawa, Proton motive ATP synthesis, in: “Bionergetics”, New Comprehensive Biochemistry, L. Ernster, ed., Elsevier/North-Ho11and Biomedical Press, Amsterdam, vol. 9, pp. 149 (1984).
J.K. Pollak and R. Sutton, The transport and accumulation of adenine nucleotides during mitochondrial biogenesis, Biochem. J. 192: 75 (1980).
J. Austin and J.R. Aprille, Carboxyatractyloside-insensitive influx and efflux of adenine nucleotides in rat liver mitochondria, J.Biol. Chem. 259: 154 (1984).
J. M. Izquierdo, A.M. Luis and J.M. Cuezva, Postnatal mitochondrial differentiation in rat liver. Regulation by thyroid hormones of the β-subunit of the mitochondrial Fi-ATPase complex, J. Biol.Chem. (in press) (1990).
C. Hackenbrock, Ultrastructural basis for metabolically linked mechanical activity in mitochondria. I. Reversible ultrastructural changes with change in metabolic steady state in isolated liver mitochondria, J.Cell.Biol. 30: 269 (1966).
C. Hackenbrock, Untrastruetural basis for metabolically linked mechanical activity in mitochondria. II. Electron transport-linked ultrastructural transformations in mitochondria, J.Cell.Biol. 37: 345 (1968).
N.E. Weber and P.V. Blair, Ultrastructural studies of beef mitochondria. II. Adenine nucleotide induced modifications of mitochondrial morphology, Biochem.Biophys.Res.Commun. 41: 821 (1970).
B. Scherser and M. Klingenberg, Demonstration of the relationship between the adenine nucleotide carrier and the structural changes of mitochondria as induced by adenosine 5’-diphosphate, Biochemistry 13: 161 (1974).
P. Lundberg, ATP and phosphate induce configurational changes of submitochondrial particles, Biochim. Biophys. Acta 376: 458 (1975).
S.F. Jakovcic, K. Haddock, G.S. Geta, M. Rabinowitz and H. Swift, Mitochondrial development in liver of foetal and newborn rats, Biochem. J. 121: 341 (1971).
G. P. Brierley, The uptake and extrusion of monovalent cations by isolated heart mitochondria, Mol.Cell.Biochem. 10: 41 (1976).
K.D. Garlid, Unmasking the mitochondrial K /H exchanger: tetraethyl-ammoniurn-induced K loss, Biochem.Biophys. Res. Commun. 87: 842 (1979).
K.D. Garlid, On the mechanism of regulation of the mitochondrial K /H exchanger, J.Biol.Chem. 255: 11273 (1980).
R.S. Dordick, G.P. Brierley and K.D. Garlid, On the mechanism of A23187-induced potassium efflux in rat liver mitochondria, J. Biol.Chem. 255: 10299 (1980).
G.P. Brierley, M. S. Jurkowitz, T. Farooqui and D. W. Jung, K+/H+ antiport in heart mitochondria, J.Biol.Chem. 259: 14672 (1984).
A. Panov, S. Flippova and V. Lyakhovich, Adenine nucleotide translocase as a site of regulation by ADP of the rat liver mitochondria permeability to H and K ions, Arch.Biochem.Biophys. 199: 420 (1980).
A.P. Halestrap, The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism, Biochim. Biophys. Acta 973: 355 (1989).
E.C. Slater, J.A. Berder and M.A. Herweijer, A hypothesis for the mechanism of respiratory-chain phosphorylation not involving the eletrochemical gradient of protons as obligatory intermediate, Biochim.Biophys. Acta 811: 217 (1985).
J.M. Cuezva and J.M. Medina, Adenine nucleotide concentrations in liver of fetal rats. Neonatal changes in the premature newborn, Rev. Esp. Flsiol. 38: 161 (1982).
J.M. Cuezva, C.I. Chitra and M.S. Patel, The newborn of diabetic rat II. Impaired gluconeogenesis in the postnatal period, Pediatr.Res. 16: 638 (1982).
E. Serrano, A.M. Luis, P. Encabo, A. Alconada, L. Ho, M.S. Patel and J.M. Cuezva, Rapid postnatal induction of the pyruvate dehydrogenase complex in rat liver mitochondria, Annals N. Y.Acad.Sei. 573: 412 (1989).
D.G. Nicholls and R. Locke, Brown adipose tissue in the mammalian neonate, Physiol. Rev. 64: 1 (1984).
J. Nedergaard, E. Connolly and B. Cannon, Thermogenic mechanisms in brown fat: “Brown Adipose Tissue”, P. Trayhurn and D.G. Nicholls, eds., Edward Arnold Ltd., London, pp. 152 (1986).
D. Ricquier, F. Bovillaud, P. Toumelin, G. Mory, R. Bazin, J. Arch and L. Penicaud, Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue: Evidence for a rapid β-adrenoreeeptor-mediated and transcriptionally regulated step during activation of thermogenesis, J.Biol.Chem. 261: 13905 (1986).
A.M. Luis and J.M. Cuezva, Rapid postnatal changes in F1-ATPase proteins and in the uncoupling protein in brown adipose tissue mitochondria of the newborn rat, Biochem.Biophys.Res. Commun. 159: 216 (1989).
J.M. Cuezva, M. Benito, F.J. Moreno and J.M. Medina, Prematurity in rat. II. Effect of hypothermia, Biol.Neonate. 37: 218 (1980).
E.D. Saggerson, T.W.J. McAllister and H. Baht, Lipogenesis in rat brown adipocytes, Biochem. J. 251: 701 (1988).
D. Ricquier, G. Mory, F. Bovillaud, J. Thibault and J. Wissenbach, Rapid increase of mitochondrial uncoupling protein and its mRNA in stimulated brown adipose tissue, FEBS Lett. 178: 240 (1984).
A. Jacobsson, U. Stadler, M.A. Glotzler and L.P. Kozak, Mitochondrial uncoupling protein from mouse brown fat: Molecular cloning, genetic mapping and mRNA expression, J.Biol.Chem. 260: 16250 (1985).
J.M. Cuezva, F.J. Moreno and J.M. Medina, Prematurity in the rat. I. Fuels and gluconeogenic enzymes, Biol.Neonate 88 (1980).
J.M. Cuezva, F.J. Moreno and J.M. Medina, Blood oxygen concentrations in premature newborn rats during the early neonatal period, IRCS Med. Sei.Biochem. 39: 644 (1981).
J.M. Cuezva and J.M. Medina, Prematurity in the rat, III. Effect of oxygen supply, Biol.Neonate 39: 70 (1981).
J.M. Medina, J.M. Cuezva and F. Mayor, Non-gluconeogenic fate of lactate during the early neonatal period in the rat, FEBS Lett. 114: 132 (1980)
J.M. Cuezva, C. Valcarce and J.M. Medina, Substrate availability for maintenance of energy homeostasis in the inmediate postnatal period of the fasted newborn rat, in.: “The Physiological Development of the Fetus and Newborn”, C.T. Jones and P.W. Nathanieslz, eds., Academic Press, London, pp. 63 (1985).
E. Fernández, C. Valcarce, J.M. Cuezva and J.M. Medina, Postnatal hypoglycemia and gluconeogenesis in the newborn rat, Biochem. J. 214: 5250 (1983).
J. H. Oppenheimer and H.H. Samuels, “Molecular Basis of Thyroid Hormone Action”, Academic Press Inc., New York, (1983).
H.H. Samuels, B.M. Forman, Z.D. Horowitz and Z.S. Ye, Regulation of gene expression by thyroid hormone, J.Clin.Invest 81: 957 (1988).
M.D. Brand and M.P. Murphy, Control of electron flux through the respiratory chain in mitochondria and cells, Biol.Rev. 62: 141 (1987).
R.P. Hafner, Thyroid hormone uptake into the cell and its subsequent localization to the mitochondria, FEBS Lett. 224:251–256 (1987).
K. Sterling, M.A. Brener and T. Sakurada, Rapid effect of triiodothyronine on the mitochondrial pathway in rat liver in vivo, Science 210: 340 (1980).
K. Sterling, Thyroid hormone action at the cell level, N.Engl.J.Med. 300: 117 (1979).
N. M. Gadaleta, M. Renis, G.R. Minervini, E. Serra, T. Bleve, A. Giovine, G. Zacheo and A. M. Giuffrida, Effect of hypothyroidism on the biogenesis of free mitochondria in the cerebral hemispheres and in cerebellum of rat during postnatal development, Neurochem.Res. 10: 163 (1985).
C.A. Batie and M.A. Verity, Membrane enzyme development in nerve ending mitochondria during neonatal hypothyroidism, Dev.Neurosei. 2: 139 (1979).
B.D. Nelson, A. Mutvei and V. Joste, Regulation of biosynthesis of the rat liver inner mitochondrial membrane by thyroid hormone, Arch. Biochem.Biophys. 228: 41 (1984).
H.J. Seitz, M.J. Müller and S. Soboll, Rapid thyroid hormone effect on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell, Biochem. J. 227: 149 (1985).
W.E. Thomas and J. Mowbray, Receptor mediated amplification control of oxidative phosphorylation by tri-iodothyronine, Biochem.Soc.Trans. 15: 669 (1987).
K. Sterling, Direct thyroid hormone activation of mitochondria: The role of adenine nucleoside translocase, Endocrino1ogy 119: 292 (1986).
J.E. Silva and P.R. Larsen, Comparison of iodothyronine 5’-deiodinase and other thyroid-hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat, J. Clin.Invest. 70: 1110 (1982).
J.M. Cuezva, E.S. Burkett, D.S. Kerr, H.M. Rodman and M. S. Patel, The newborn of diabetic rat, I. Hormonal and metabolic changes” in the postnatal period, Pediatr.Res. 16: 632 (1982).
J.M. Cuezva and M.S. Patel, Disturbances of fetal liver carbohydrate metabolism and perinatal glucose homeostasis, Biochem.Soc.Trans. 13: 83 (1985).
J.M. Cuezva and M.S. Patel, Effect of glucose and insulin administration on hepatic adenylate energy charge and the cytosolic redox state in the neonates of normal and insulin-treated diabetic rats, Biol. Neonate 48: 221 (1985).
J.R. Aprille and M. T. Nosek, Neonatal hypoxia or maternal diabetes delays postnatal development of liver mitochondria, Pediatr.Res. 21: 266 (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Cuezva, J.M., Valcarce, C., Luis, A.M., Izquierdo, J.M., Alconada, A., Chamorro, M. (1990). Postnatal Mitochondrial Differentiation in the Newborn Rat. In: Cuezva, J.M., Pascual-Leone, A.M., Patel, M.S. (eds) Endocrine and Biochemical Development of the Fetus and Neonate. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9567-0_14
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9567-0_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9569-4
Online ISBN: 978-1-4615-9567-0
eBook Packages: Springer Book Archive