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Endocrine and Biochemical Development of the Fetus and Neonate pp 101–112Cite as

Perinatal Development of Liver Mitochondrial Function

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Part of the book series: Reproductive Biology ((RBIO))

Abstract

Just before birth, liver mitochondria are relatively undeveloped with respect to a capacity for aerobic ATP synthesis. They also lack the ability to perform certain reactions compartmentalized in the matrix that are an essential part of metabolic pathways such as gluconeogenesis, ureagenesis, and fatty acid oxidation. The postnatal development of these mitochondrial activities is a prerequisite for independent metabolism in the neonate. Morphologically, compared to postnatal mitochondria, prenatal mitochondria are: larger; more variable in shape; have fewer cristae; are fewer in number per cell; and have a higher equilibrium density. Shortly after birth the mitochondria begin to proliferate. Details of all these enzymatic, functional and morphological aspects of mitochondrial development in the perinatal period were reviewed recently (1). This paper will focus on some interesting regulatory events that occur immediately after birth.

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Author information

Authors and Affiliations

  1. Mitochondrial Physiology Unit Department of Biology, Tufts University, Medford, MA 02155, USA

    June R. Aprille

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  1. June R. Aprille
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Editor information

Editors and Affiliations

  1. Universidad Autonoma de Madrid, Madrid, Spain

    José M. Cuezva

  2. C.S.I.C. Universidad Complutense de Madrid, Madrid, Spain

    Ana M. Pascual-Leone

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Mulchand S. Patel

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© 1990 Plenum Press, New York

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Aprille, J.R. (1990). Perinatal Development of Liver Mitochondrial Function. In: Cuezva, J.M., Pascual-Leone, A.M., Patel, M.S. (eds) Endocrine and Biochemical Development of the Fetus and Neonate. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9567-0_13

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  • DOI: https://doi.org/10.1007/978-1-4615-9567-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9569-4

  • Online ISBN: 978-1-4615-9567-0

  • eBook Packages: Springer Book Archive

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