Abstract
Respiratory distress syndrome (RDS) in infants was first described in 1959 by Avery and Mead who showed it results from a deficiency of surfactant, a phospholipid-protein complex, in the lung. RDS, also called hyaline membrane disease, is most prevalent in premature infants. This lung abnormality has interested many scientists and clinicians and has led to a greater understanding of the biochemistry of the lung and to the elucidation of the components of lung surfactant. To understand the function of lung surfactant, it is appropriate to consider first the overall gross anatomy of the lung (Fig. 9–1).
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References
Avery, M. G., and Mead, J., 1959, Surface properties in relation to atelectasis and hyaline membrane disease, Am. J. Dis. Child., 97:517.
Clements, J. A., 1970, Pulmonary surfactant, Am. Rev. Respir. Dis., 101:984.
Clements, J. A., 1974, Biochemical aspects of pulmonary function, Fed. Proc., 33:2231.
Erbland, J., and Marinetti, G. V., 1965a, The enzymatic acylation and hydrolysis of lysolecithin, Biochim. Biophys. Acta., 106:128
Erbland, J., and Marinetti, G. V., 1965b, The metabolism of lysolecithin in rat liver particulate systems, Biochim. Biophys. Acta, 106:139.
Farrell, P. M., and Avery, M. E., 1975, Hyaline membrane disease, Am. Rev. Respir. Dis., 111:657.
Hawthorne, J. N., and Ansell, G. B. (eds.), 1982, Phospholipids, Elsevier, Amsterdam, The Netherlands.
Infante, J. P., and Huszagh, V. A., 1987, Is there a new biosynthetic pathway for lung surfactant phosphatidylcholine, Trends Biochem. Sci., 12:131.
King, R. J., 1974, The surfactant system of the lung, Fed. Proc., 33:2254.
King, R. J., 1979, Pulmonary surface active material: basic concepts, in The Surfactant System and the Neonatal Lung, Mead Johnson Symposium on Perinatal and Developmental Medicine, published by Mead Johnson & Co., Evansville, Indiana, No. 14, p. 3.
King, R. J., Carmichael, M. C., and Horowitz, C. M., 1983, Reassembly of lipid-protein complexes of pulmonary surfactant: proposed mechanism of interaction, J. Biol. Chem., 258:10672.
Morgan, T. E., 1971, Pulmonary surfactant, N. Engl. J. Med., 284:1185.
Notter, R. H., and Shapiro, D. L., 1981, Lung surfactant in an era of replacement therapy, Pediatrics, 68:781.
Pelech, S. L., and Vance, D. E., 1984, Regulation of phosphatidylcholine biosynthesis, Biochim. Biophys. Acta, 779:217.
Post, M., and van Golde, L. M. G., 1988, Metabolic and developmental aspects of the pulmonary surfactant system. Biochim. Biophys. Acta, 947:249.
Rooney, S. A., 1975, Development of pulmonary surfactant system during late fetal and early postnatal life, Am. Rev. Respir. Dis., 111:657.
Rooney, S. A., 1979, Pulmonary surface active material: basic concepts, in The Surfactant System and the Neonatal Lung, Mead Johnson Symposium on Perinatal and Developmental Medicine, published by Mead Johnson & Co., Evansville, Indiana, No. 14, p. 17.
Smith, B. T., 1979, The surfactant system and the neonatal lung, in Biochemistry and Metabolism of Pulmonary Surface-active Material, Mead, Johnson Symposium on Perinatal and Developmental Medicine, published by Mead Johnson & Co., Evansville, Indiana, No. 14, p. 12.
Smith, E. L., Hill, R. L., Lehman, I. R., Lefkowitz, R. J., Handle, P., and White, A., 1983a, Principles of Biochemistry: Mammalian Biochemistry, 7th ed., McGraw-Hill Book Co., New York.
Smith, E. L., Hill, R. L., Lehman, I. R., Lefkowitz, R. J., Handler, P., and White, A., 1983b, Principles of Biochemistry: General Aspects, 7th ed., McGraw-Hill Book Co., New York.
Staub, N. C., 1970, The pathophysiology of pulmonary edema, Hum. Pathol., 1:419.
Tierney, D. F., 1974, Intermediary metabolism of the lung, Fed. Proc., 33:2232.
Von Neergaard, K., 1929, Neue auffassungen uber einen grundbegriff der atemmechanik, Z. Ges. Exptl. Med., 66:373.
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© 1990 Plenum Press, New York
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Marinetti, G.V. (1990). Lung Surfactant Deficiency. In: Disorders of Lipid Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9564-9_10
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DOI: https://doi.org/10.1007/978-1-4615-9564-9_10
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