Abstract
Peritoneal cavity lymphatic absorption significantly reduces net ultrafiltration (UF) and solute clearances in peritoneal dialysis.(1,2) Lymphatic absorption from the peritoneal cavity occurs primarily via the subdiaphragmatic stomata(3) which constrict following intraperitoneal administration of cholinergic drugs.(4) Neostigmine, an anticholinesterase agent, is also thought to reduce the patency of the subdiaphragmatic stomata and so may reduce lymphatic drainage of intraperitoneal fluid. This study was performed to evaluate net UF, solute clearances, and lymphatic absorption during single hypertonic exchanges in rats using 2.5% dextrose dialysis solution with and without added neostigmine.
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References
Mactier RA, Khanna R, Twardowski Z, Nolph KD Kidney Int 1987; 31: 252A.
Nolph KD, Mactier RA, Khanna R, Twardowski ZJ, Moore HL Kidney Int (in press).
Courtice FC, Simmonds WJ Physiol Rev 1954; 34: 419–448.
Tsilibary EC, Wissig SL Microvasc Res 1983; 25: 22–39.
Lill SR, Parsons RH, Bohac I Gastroenterology 1979; 76: 997–1001.
Aune S Scand J Gastroenterol 1970;5:241–252.
Nicoll PA, Taylor AE Ann Rev Physiol 1977; 39: 73–95.
Henriksen JH, Larsen LA, Parving H, Winkler K Scand J Lab Clin Invest 1980; 40: 503–513.
Zink J, Greenway CV Gastroenterology 1977; 73: 1119–1124.
Higgins GM, Beaver MG, Lemon WS Am J Anat 1930; 45: 137–157.
Morris B Austral J Exp. Biol Med Sci 1953;31:239–246.
Twardowski ZJ, Khanna R, Nolph KD, et al. Nephron 1986; 44: 129–135.
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© 1990 Plenum Publishing Corporation
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Mactier, R.A., Khanna, R., Moore, H.L., Twardowski, Z.J., Nolph, K.D. (1990). Neostigmine Increases Net Ultrafiltration and Solute Clearances in Peritoneal Dialysis by Reducing Lymphatic Absorption. In: Avram, M.M., et al. Ambulatory Peritoneal Dialysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9555-7_7
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DOI: https://doi.org/10.1007/978-1-4615-9555-7_7
Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4615-9555-7
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