Abstract
Tangier disease is characterized by the absence of normal HDL in plasma and by the accumulation of cholesterol esters in various tissues. These include the liver, spleen, lymph nodes, thymus, intestinal mucosa, skin and probably the cornea.
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References
G. Assmann, 6. Schmitz, and H.B. Brewer, Familial lipoprotein deficiency: Abetalipoproteinemia, Hypobetalipoproteinemia and Tangier Disease, in: The Metabolic Basis of Inherited Disease. McGraw-Hill, New York 6. ed., chapter 29 (1988), (in press).
M.S. Brown, and J.L. Goldstein, Lipoprotein metabolism in the macrophages implications for cholesterol deposition in atherosclerosis, Ann. Rev. Biochem. 52: 223–261 (1983).
Y.K. Ho, M.S. Brown, and J.L. Goldstein, Hydrolysis and excretion of cytoplasmic cholesterol esters by macrophages: stimulation by high density lipoproteins and other agents, J. Lipid Res. 21: 391–398 (1980).
G. Schmitz, H. Robenek, H. Lohmann, and G. Assmann, Interactions of high density lipoproteins with macrophages: biochemical and morphological characterization of cell surface receptor binding, endocytosis and resecretion of high density lipoproteins by macrophages, EMBO J. 4: 613–622 (1985).
G. Schmitz, R. Niemann, B. Brennhausen, R. Krause, and G. Assmann, Regulation of high density lipoprotein receptors in cultured macrophages: role of acyl-CoA: cholesterol acyltransferase, EMBO J. 4: 2773–2779 (1985).
G. Schmitz, G. Wulf, and Th. Brüning, Flow-Cytometric Determination of high-density-1ipoprd tein binding sites on human leukocytes, Clin. Chem. 33: 2195–2203 (1987).
G. Schmitz, H. Robenek, M. Beuck, R. Krause, A. Schurek, and R. Niemann, Calcium antagonists and ACAT-inhibitors promote cholesterol efflux from macrophages by different mechanisms. I. Charaterization of cellular lipid metabolism, Arteriosclerosis 8: 46–56 (1988).
H. Robenek, and G. Schmitz, Calcium antagonists and ACAT-inhibitors promote cholesterol efflux from macro-phages by different mechanisms. II. Characterization of intracellular morphologic changes, Arteriosclerosis 8: 57–67 (1988).
G. Schmitz, G. Assmann, H. Robenek, and B. Brennhausen, Tangier disease: A disorder of intracellular membrane traffic, Proc. Natl. Acad. Sci. USA, 82: 6305–6309 (1985).
G. Schmitz, G. Assmann, B. Brennhausen, and H.-E. Schaefer, Interaction of Tangier lipoproteins with cholesterol ester-laden mouse peritoneal macrophages, J. Lipid Res. 28: 87–99 (1987).
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© 1989 Plenum Press, New York
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Schmitz, G., Robenek, H., Brennhausen, B., Assmann, G. (1989). Abnormal Processing of HDL Precursors in Tangier Monocyte Derived Macrophages. In: Sirtori, C.R., Franceschini, G., Brewer, H.B., Assmann, G. (eds) Human Apolipoprotein Mutants 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9549-6_21
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DOI: https://doi.org/10.1007/978-1-4615-9549-6_21
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