Abstract
Plasma lipid levels have a high variability within and in-between populations. Genetic factors are involved in controlling plasma lipid levels and explain more than 50% of the variance of total plasma cholesterol levels in Caucasian populations. Single polymorphic genes affecting plasma lipid levels have only recently been identified (for review see Utermann, 1985, 1987a,b, 1988; Lusis, 1988).
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References
Albers, J. J., and Hazzard, W. R., 1974, Immunochemical quantification of human plasma Lp(a) lipoprotein, Lipids, 9: 15
Beisiegel, U., and Utermann, G., 1979, An apolipoprotein homology of rat apolipoprotein A-IV in human plasma, Eur J Biochem., 93: 601
Berg, K., 1963, A new serum type system in man: the Lp-system, Acta Pathol Microbiol Scand., 59: 369.
Boerwinkle, E., Visvikis, S., Welsh, D., Steinmetz, J., Hanash, S. M., and Sing, C. F., 1987, The Use of Measured Genotype.Information in the Analysis of Quantitative Phenotypes in Man, Am J Med Genet., 27: 567.
Boerwinkle, E., and Utermann, G., 1988, Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B and cholesterol metabolism, Am J Hum Genet., 42: 104.
Brown, M. S., and Goldstein, J. L., 1986, A receptor mediated pathway for cholesterol homeostasis, Science, 232: 34.
Brwon, M. S., and Goldstein, J. L., 1987, Plasma lipoproteins: Teaching old dogmas nwe tricks, Nature, 330: 113.
Davignon, J., Gregg, R. E., and Sing, C. F., 1988, Apolipoprotein E polymorphism and atherosclerosis, Arterioscl., 8: 1.
Dvorin, E., Gordon, N. L., Benson, D. M., and Gotto Jr. A. M., 1986, Apolipoprotein A-IV A determinant for binding and uptake of high density lipoprotein by rat hepatocytes, J Biol Chem., 261: 15714.
Eaton, D. L., Fless, G. M., Kohr, W. J., Mc Lean, J. W., Xu, Q.-T., Miller, C.G., Lawn, R. W., and Scanu, A. M., 1987, Partial amino acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen, Proc Natl Acad Sci. USA, 84: 3224.
Gregg, R. E., Zech, L. A., Schaefer, E. J., Stark, D., Wilson, D., and Brewer, Jr. H. B., 1986, Abnormal in vivo metabolism of apolipoprotein E4 in humans, J Clin Invest., 78: 815.
Hasstedt, S. J., and Williams, R. R., 1986, Three alleles for quantitative Lp(a), Genet Epidemiol., 3: 53.
Klasen, E. C., Smit, M., De Kniff, P., Leuven, J. G., Kempen-Voogd, R., and Havekes, L., 1987, Apolipoprotein E Phenotype and Gene Distribution in the Netherlands, Hum Hered., 37: 340.
Kraft, H. G., Dieplinger, H., Hoye, E., and Utermann, G., 1988, Lp(a) phenotyping by immunoblotting with polyclonal and monoclonal antibodies, Arterioscl.,. 8: 212.
Kratzin, H., Armstrong, V. W., Niehaus, M., Hilschman, N., and Seidel, D., 1987, Structural relationship of an apolipoprotein(a) phenotype (570 K Da) to plasminogen: Homologous kringle domains are linked by carbohydrate-rich region, Hoppe-Seylerxs Z Biol Chem., 368: 1533.
Lusis, A. J., 1988, Genetic factors affecting blood lipoproteins. The candidate gene approach, J Lipid Res., 29: 397.
Mahley, R. W., 1988, Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology, Science, 240: 622.
Mc Lean, J. W., Tomlinson, J. E., Kuang, W., Eaton, D. L., Chen, E. Y., Fless, G. M., Scanu, A. M., and Lawn, R. M., 1987, cDNA sequence of human apolipoprotein(a) is homologous to plasminogen, Nature, 330: 132.
Menzel, H. J., Kövary, P. M., and Assmann, G., 1982, Apolipoprotein A-IV Polymorphism in Man, Hum Genet., 62: 349.
Menzel, H. J., Boerwinkle, E., Schrangl-Will, S., and Utermann, G., 1988, Human apolipoprotein A-IV polymorphism: frequency and effect on lipid and lipoprotein levels. Hum Genet., in press.
Morganti, G., and Beolchini, P. E., 1972, contribution to the genetics of serum ß-lipoprotein in man, Hum Genet., 16: 307.
Rail, S. C. Jr., Weisgraber, K. H., and Mahley, R. W., 1982, Human apolipoprotein E. The complete amino acid sequence, J Biol Chem., 257: 4171.
Rhoads, G. G., Dahlen, G., Berg, K., Morton, N. E., and Dannenberg, A. L., 1986, Lp(a) lipoprotein as a risk factor for myocardial infarction, JAMA, 256: 2540.
Rosseneu, M., Michiels, G., de Keersgleter, W., Bury, J., De Slypere, J. P., Dieplinger, H., and Utermann, G., 1988, Quantification of human apolipoprotein A-IV by “Sandwich”-type enzyme linked immunosorbent assay, Clin Chem., 34: 739.
Schneider, W. J., Kovanen, P. T., Brown, M. S., Goldstein, J. L., Utermann, G., Weber, W., Havel, R. J., Kotite, L., Kane, J. P., Innerarity, T. L., and Mahley, R. W., 1981, Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenals of rats, rabbits, and cows, J Clin Invest., 68: 1075.
Sing, C. F., Schultz, J. S., and Shreffler, D. C., 1974, The genetics of the Lp-antigen II, Ann Hum Genet., 38: 47.
Steinmetz, A., and Utermann, G., 1985, Activation of lecithin: cholesterol acyltransferase by human apolipoprotein A-IV, J Biol Chem., 260: 2258.
Utermann, G., Hees, M., and Steinmetz, A., 1977, Polymorphism of apolipoprotein E and occurance of dysbetalipoproteinemia in man, Nature 604.
Utermann, G., Pruin, N., and Steinmetz, A., 1979, Polymorphism of apolipoprotein E. Ill: Effect of a single polymorphic gene locus on plasma lipid levels in man, Clin Genet., 15: 63.
Utermann, G., Feussner, G., Franceschini, G., and Steinmetz, A., 1982, Genetic Variants of Group A Apolipoproteins. J Biol Chem., 257: 501.
Utermann, G., 1985, Genetic polymorphism of apolipoprotein E — impact on plasma lipoprotein metabolism, in: “Diabetes, obesity and hyper- lipidemias-III,” G. Crepaldi, ed., Elsevier Science Publishers, New York, pp 1.
Utermann, G., Menzel, H. J., Kraft, H. G., Duba, H. C., Kemmler, H. G., and Seiß, C. 1987, Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentration in plasma, J Clin Invest., 80: 458.
Utermann, G., 1987a, Apolipoproteins, quantitative lipoprotein traits and multifactorial hyperlipidemia, in: “CIBA Foundation Symposium 130”, Wiley, Chichester, pp 52.
Utermann, G., 1987b, Apolipoprotein E polymorphism in health and disease, Am Heart J., 113: 433.
Utermann, G., Duba, C., and Menzel, H. J., 1988, Genetics of the quantitative Lp(a) lipoprotein trait, Hum Genet., 78: 47.
Utermann, G., 1988, Apolipoprotein variation: Effect on plasma lipid variability, J Inher Metab Pis., in press
Wiegandt, H., Lipp, K., and Wendt, G., 1968, Identifizierung eines Lipoproteins mit Antigenwirksamkeit im Lp-System, Hoppe-Seyler’s Z Physiol Chem., 349: 489.
Young, S. G., Bertics, S. J., Curtiss, L. K., Casal, D. C., and Witztum, L., 1986, Monoclonal antibody MB 19 detects genetic polymorphism in human apolipoprotein B, Proc Natl Acad Sci. USA, 83: 1101.
Zannis, V. I., and Breslow, J. L., 1981, Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and post-translational modification, Biochemistry, 20: 1033.
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© 1989 Plenum Press, New York
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Utermann, G. (1989). Apolipoprotein Variation: Effect on Plasma Lipid Variability. In: Sirtori, C.R., Franceschini, G., Brewer, H.B., Assmann, G. (eds) Human Apolipoprotein Mutants 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9549-6_2
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DOI: https://doi.org/10.1007/978-1-4615-9549-6_2
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