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RFLPS of ApoB Gene

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Human Apolipoprotein Mutants 2

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Abstract

Epidemiological studies have shown1–3 that the plasma concentration of LDL cholesterol and apolipoprotein B-100 are positively correlated with the incidence of coronary artery disease. ApoB-100 is believed to have an important role in the alteration of lipid metabolism that may lead to premature atherosclerosis2,4. Apolipoprotein B-100 is the molecular determinant of some apoB-containing lipoproteins, serving as a recognition signal for LDL receptor-mediated endocytosis in a variety of cells5. More information on the nature of the protein is being obtained through the techniques of molecular biology. In recent years (1985–1986)6–10 the amino acid sequence of apoB-100 was deduced from the nucleotidic sequences of a number of cDNAs and genomic DNAs, which were isolated from human liver, intestine, and hepatoma libraries.

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Author information

Authors and Affiliations

  1. The Methodist Hospital, Houston, TX, 77030, USA

    F. Turturro, J. Heibig, G. C. Ghiselli & A. M. Gotto Jr.

  2. The Vetrans Administration Medical Center, Houston, TX, 77032, USA

    F. Turturro, J. Heibig, G. C. Ghiselli & A. M. Gotto Jr.

Authors
  1. F. Turturro
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  2. J. Heibig
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  3. G. C. Ghiselli
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  4. A. M. Gotto Jr.
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Editor information

Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    C. R. Sirtori  & G. Franceschini  & 

  2. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA

    H. B. Brewer Jr.

  3. University of Münster, Münster, Federal Republic of Germany

    G. Assmann

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© 1989 Plenum Press, New York

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Turturro, F., Heibig, J., Ghiselli, G.C., Gotto, A.M. (1989). RFLPS of ApoB Gene. In: Sirtori, C.R., Franceschini, G., Brewer, H.B., Assmann, G. (eds) Human Apolipoprotein Mutants 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9549-6_12

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  • DOI: https://doi.org/10.1007/978-1-4615-9549-6_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9551-9

  • Online ISBN: 978-1-4615-9549-6

  • eBook Packages: Springer Book Archive

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