Abstract
The classical pharmacological actions of kinins that occur at umol and higher concentrations comprise the interaction with pain receptors, stimulation of smooth muscle contraction, vasodilatation and an increase of vascular permeability. Thus kinins were thought to be circulatory active peptides that are in some way involved in inflammatory processes. With the development of highly sensitive radioimmunoassays as well as sophisticated procedures for blood sampling and kinin extraction, the concentration ranges that were thought to be normal had to be gradually corrected until we now know that kinins are circulating in low picomolar concentrations1. Furthermore, in the past few years animal models2 3 as well as in vivo observations in man4 yielded evidence, that in these low concentration ranges kinins exhibit insulin-like effects on carbohydrate and protein metabolism of muscle tissue. Moreover, kinins appear to improve disturbed peripheral insulin sensitivity in insulin-resistant states like postoperative stress and non-insulin dependent diabetes — without exhibiting any systemic cardiovascular effect5-7.
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© 1989 Plenum Press, New York
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Rett, K., Jauch, K.W., Wicklmayr, M., Fink, E., Dietze, G.J., Mehnert, H. (1989). Increased Insulin-Responsiveness by Ace-Inhibition in Non-Insulin Dependent Diabetes Mellitus. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_29
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DOI: https://doi.org/10.1007/978-1-4615-9543-4_29
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