Abstract
It is generally recognized that the cortical collecting duct plays a major role in the fine control of renal sodium excretion, and thus in the regulation of extracellular fluid volume. Several lines of evidence point to the cortical collecting duct as a possible site of kinin action on sodium transport. First, both kallikrein1-3 and kininogen4 have been localized to the collecting duct system. Second, high-affinity binding sites for bradykinin have recently been localized to the cortical and outer medullary collecting ducts5. Third, kinins have a marked inhibitory effect on vasopressin-stimulated water permeability in the isolated, perfused cortical collecting duct of the rabbit. First part of our studies is to investigate whether bradykinin directly affects net sodium transport in the cortical collecting duct of the rat using the isolated, perfused tubule technique.
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© 1989 Plenum Press, New York
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Tomita, K., Ujiie, K., Maeda, Y., Iino, Y., Yoshiyama, N., Shiigai, T. (1989). Effects of Kinin on Electrolytes Transport and Regulation of Kininase Activity in Distal Nephron Segments of the Rat. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_14
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DOI: https://doi.org/10.1007/978-1-4615-9543-4_14
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