Abstract
It is well known that anthracycline antibiotics having an anthraquinone group in the molecule are an important class of widely used antitumor antibiotics1. Their clinical efficacy is limited by severe doserelated cardiotoxicity1,2. It has been considered that these undesirable side effects as well as the clinical benefits result from their ability to shuttle electrons from NADPH-cytochrome P-450 reductase to molecular oxygen that is, in turn, transformed into activated oxygen species such as superoxide anion radical, hydroxyl radical, and hydrogen peroxide1–3. The activated oxygen species have been proposed to play a fatal role in DNA scission4 and peroxidation of mitochondrial membranes5. However, the detailed mechanism is not yet fully understood.
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Kano, K., Konse, T., Uno, B., Kubota, T. (1988). Electrochemical Study of the Mechanism and Kinetics of Oxygen Reduction Mediated by Anthracycline Antibiotics Adsorbed on Electrode Surface. In: Dryhurst, G., Niki, K. (eds) Redox Chemistry and Interfacial Behavior of Biological Molecules. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9534-2_19
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DOI: https://doi.org/10.1007/978-1-4615-9534-2_19
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