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Regulation of the Primate Corpus Luteum During Early Pregnancy

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The Primate Ovary

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

Abstract

In women and many nonhuman primates, the life span of the corpus luteum during the nonfertile menstrual cycle is limited to approximately 2 weeks. However, the interval of luteal function is extended when conception and pregnancy follow ovulation. The so-called “rescue” (1) and continued function of the corpus luteum in early pregnancy is essential until the endocrine activities, notably progesterone production, are assumed by the placenta. Ovariectomy or lutectomy prior to the development of placental steroidogenesis causes abortion unless progesterone supplements are provided (2). The luteal-placental shift occurs near the end of the third week of gestation in rhesus monkeys (3) and at 6 weeks in women (2). Hence, the corpus luteum of the fertile cycle must function for an additional 1–4 weeks to ensure continued pregnancy in these species.

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References

  1. Knobil E. On the regulation of the primate corpus luteum. Biol Reprod 1973; 8:246–58.

    CAS  Google Scholar 

  2. Tullner WW. Comparative aspects of primate chorionic gonadotropins. In: Kuhn H, ed. Contributions to Primatology vol 3. Basel, Switzerland: S Karger, 1984:235–57.

    Google Scholar 

  3. Goodman AL, Hodgen GD. Corpus luteum-conceptus-follicle relationships during the fertile cycle in rhesus monkeys: pregnancy maintenance despite early luteal removal. J Clin Endocrinol Metab 1979; 49:469–71.

    Article  PubMed  CAS  Google Scholar 

  4. Hodgen GD, Niemann WH, Tullner WW. Duration of chorionic gonadotropin production by the placenta of the rhesus monkey. Endocrinology 1975; 96:789–91.

    Article  PubMed  CAS  Google Scholar 

  5. Hearn JP. The embryo-maternal dialogue during early pregnancy in primates. J Reprod Fertil 1986; 76:809–19.

    Article  PubMed  CAS  Google Scholar 

  6. Meyer RK. Chorionic gonadotropin, corpus luteum function and embryo implantation in the rhesus monkey. Acta Endocrinol [suppl] 1972; 166:214–7.

    CAS  Google Scholar 

  7. Prahalada S, Venkatramaiah M, Rao AJ, Moudgal NR. Termination of pregnancy in macaques (Macaca radiata) using monkey antiserum to ovine LH. Contraception 1975; 12:137–47.

    Article  PubMed  CAS  Google Scholar 

  8. Talwar GP, Sharma NC, Dubey SK, et al. Isoimmunization against hCG with conjugates of processed β-subunit of the hormone and tetanus toxoid. Proc Natl Acad Sci USA 1976; 73:218–22.

    Article  PubMed  CAS  Google Scholar 

  9. Stevens VC. Immunization of female baboons with hapten-coupled gonadotropins. J Obstet Gynecol 1973; 42:496–506.

    Article  CAS  Google Scholar 

  10. Thau RB, Sundaram K. The mechanisms of action of an antifertility vaccine in the rhesus monkey: reversal of the effects of antisera to β-oLH by medroxyprogesterone acetate. Fertil Steril 1980; 33:317–20.

    PubMed  CAS  Google Scholar 

  11. Strott CA, Yoshimi T, Ross GT, Lipsett MB. Ovarian physiology: relationship between plasma LH and steroidogenesis by the follicle and corpus luteum; effect of hCG. J Clin Endocrinol Metab 1969; 29:1157–67.

    Article  PubMed  CAS  Google Scholar 

  12. Hanson FW, Powell JE, Stevens VC. Effects of hCG and human pituitary LH on steroid secretion and functional life of the human corpus luteum. J Clin Endocrinol Metab 1971; 32:211–5.

    Article  PubMed  CAS  Google Scholar 

  13. Neill JD, Knobil E. On the nature of the initial luteotropic stimulus of pregnancy in the rhesus monkey. Endocrinology 1972; 90:34–8.

    Article  PubMed  CAS  Google Scholar 

  14. Surve AH, Harrington FE, Elton RL. Effect of chorionic gonadotropin on corpus luteum of the monkey. Proc Soc Exp Biol Med 1973; 144:963–8.

    PubMed  CAS  Google Scholar 

  15. Wilks JW, Noble AS. Steroidogenic responsiveness of the monkey corpus luteum to exogenous chorionic gonadotropin. Endocrinology 1983; 112:1256–66.

    Article  PubMed  CAS  Google Scholar 

  16. Ottobre JS, Stouffer RL. Persistent vs. transient stimulation of the macaque corpus luteum during prolonged exposure to hCG: a function of age of the menstrual cycle. Endocrinology 1984; 114:2175–82.

    Article  PubMed  CAS  Google Scholar 

  17. Ottobre JS, Nixon WE, Stouffer RL. Induction of relaxin secretion in rhesus monkeys by hCG: dependence on the age of the corpus luteum of the menstrual cycle. Biol Reprod 1984; 31:1000–6.

    Article  PubMed  CAS  Google Scholar 

  18. Ellendorff F, Koch E, eds. Early pregnancy factors. Proceedings of an International Workshop April 17–19, 1985, Mariensee, West Germany. New York: Perinatology Press, 1985.

    Google Scholar 

  19. Aschheim S, Zondek B. Hypophysenvorderlappenhormon and ovarial hormon im harn von schwangeren. Klin Wochenschr 1927; 6:1322–30.

    Article  Google Scholar 

  20. Tyrey L. Human chorionic gonadotropin: structural, biologic and immunologic aspects. Semin Oncol 1982; 9:163–73.

    PubMed  CAS  Google Scholar 

  21. Schwartz M, Jewelewicz R, Dyrenfurth I, Tropper P, VandeWeile RL. The use of human menopausal and chorionic gonadotropins for induction of ovulation: sixteen years’ experience at the Sloane Hospital for Women. Am J Obstet Gynecol 1980; 138:801–7.

    PubMed  CAS  Google Scholar 

  22. Bavister BD, Boatman DE, Collins K, Dierschke DJ, Eisele SG. Birth of rhesus monkey infant after in vitro fertilization and nonsurgical embryo transfer. Proc Natl Acad Sci USA 1984; 81:2218–22.

    Article  PubMed  CAS  Google Scholar 

  23. Cameron JL, Stouffer RL. Comparisons of the species specificity of gonadotropin binding to primate and non primate corpora lutea. Biol Reprod 1981; 25:568–72.

    Article  PubMed  CAS  Google Scholar 

  24. Cameron JL, Stouffer RL. Gonadotropin receptors of the primate corpus luteum: I. Characterization of 125I-labeled hLH and hCG binding to luteal membranes from the rhesus monkey. Endocrinology 1982; 110:2059–67.

    Article  PubMed  CAS  Google Scholar 

  25. Cameron JL, Stouffer RL. Gonadotropin receptors of the primate corpus luteum: II. Changes in available LH and CG binding sites in macaque luteal membranes during the nonfertile menstrual cycle. Endocrinology 1982; 110:2068–73.

    Article  PubMed  CAS  Google Scholar 

  26. Ottobre JS, Ottobre AC, Stouffer RL. Changes in available gonadotropin receptors in the corpus luteum of the rhesus monkey during simulated early pregnancy. Endocrinology 1984; 115:198–204.

    Article  PubMed  CAS  Google Scholar 

  27. Eyster KM, Stouffer RL. Characterization of the adenylate cyclase system in the nonhuman primate (Macaca mulatta) corpus luteum. II. Sensitivity to gonadotropins, other hormones and nonhormonal activators. Endocrinology 1985; 116:1552–8.

    Article  PubMed  CAS  Google Scholar 

  28. Stouffer RL, Gulyas BJ, Nixon WE, Hodgen GD. Gonadotropin-sensitive progesterone production by rhesus monkey luteal cells in vitro: a function of age of the corpus luteum during the menstrual cycle. Endocrinology 1977; 100:506–12.

    Article  PubMed  CAS  Google Scholar 

  29. Rao CH V, Griffin LP, Carman FR Jr. Gonadotropin receptors in human corpora luteal of the menstrual cycle and pregnancy. Am J Obstet Gynecol 1976; 128:146–53.

    Google Scholar 

  30. Marsh JM, LeMaire WJ. Cyclic AMP accumulation and steroidogenesis in the human corpus luteum: effect of gonadotropins and prostaglandins. J Clin Endocrinol Metab 1974; 38:99–106.

    Article  PubMed  CAS  Google Scholar 

  31. Crowley WF Jr, Filicori M, Spratt DI, Santoro NF. The physiology of GnRH secretion in men and women. Recent Prog Horm Res 1985; 41:473–532.

    PubMed  CAS  Google Scholar 

  32. Ellinwood WE, Norman RL, Spies HG. Changing frequency of pulsatile luteinizing hormone and progesterone secretion during the luteal phase of the menstrual cycle of rhesus monkeys. Biol Reprod 1984; 31:714–22.

    Article  PubMed  CAS  Google Scholar 

  33. Hutchison JS, Nelson PB, Zeleznik AJ. Effects of different gonadotropin pulse frequencies on corpus luteum function during the menstrual cycle of rhesus monkeys. Endocrinology 1986; 119:1964–71.

    Article  PubMed  CAS  Google Scholar 

  34. Hutchison JS, Zeleznik AJ. The corpus luteum of the primate menstrual cycle is capable of recovering from a transient withdrawal of pituitary gonadotropin support. Endocrinology 1985; 117:1043–49.

    Article  PubMed  CAS  Google Scholar 

  35. Soules MR, Steiner RA, Clifton DK, Bremner WJ. The effects of inducing a follicular phase gonadotropin secretory pattern in normal women during the luteal phase. Fertil Steril 1986; 47:45–53.

    Google Scholar 

  36. Niswender GD, Schwall RH, Fitz TA, Farin CE, Sawyer HR. Regulation of luteal function in domestic ruminants: new concepts. Recent Prog Horm Res 1985; 41:101–51.

    PubMed  CAS  Google Scholar 

  37. Bazer FW, Vallet JV, Roberts RM, Sharp DC, Thatcher WW. Role of conceptus secretory products in establishment of pregnancy. J Reprod Fertil 1986; 76:841–50.

    Article  PubMed  CAS  Google Scholar 

  38. Tulchinsky D, Hobel CJ. Plasma hCG, estrone, estradiol, estriol, progesterone and 17α-hydroxyprogesterone in human pregnancy III. Early normal pregnancy. Am J Obstet Gynecol 1973; 117:884–93.

    PubMed  CAS  Google Scholar 

  39. Stouffer RL, Nixon WE, Hodgen GD. The refractory state of luteal cells isolated from rhesus monkeys after prolonged exposure to CG during early pregnancy. Biol Reprod 1978; 18:858–64.

    Article  PubMed  CAS  Google Scholar 

  40. Gwynne JT, Strauss JF III. The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands. Endocr Rev 1982; 3:299–329.

    Article  PubMed  CAS  Google Scholar 

  41. Carr BR, MacDonald PC, Simpson ER. The role of lipoproteins in the regulation of progesterone secretion by the human corpus luteum. Fertil Steril 1982; 38:303–11.

    PubMed  CAS  Google Scholar 

  42. Golos TG, August AM, Strauss JF III. Expression of low density lipoprotein receptor in cultured human granulosa cells: regulation by hCG, cyclic AMP and sterol. J Lipid Res 27:1089–96.

    Google Scholar 

  43. Booher C, Enders AC, Hendrickx AG, Hess DL. Structural characteristics of the corpus luteum during implantation in the rhesus monkey (Macaca mulatta). Am J Anat 1981; 160:17–36.

    Article  PubMed  CAS  Google Scholar 

  44. Ellinwood WE, Resko JA. Effect of inhibition of estrogen synthesis during the luteal phase on function of the corpus luteum in rhesus monkeys. Biol Reprod 1983; 28:636–44.

    Article  PubMed  CAS  Google Scholar 

  45. Schoonmaker JN, Bergman KS, Steiner RA, Karsch FJ. Estradiolinduced luteal regression in the rhesus monkey: evidence for an extraovarian site of action. Endocrinology 1982; 110:1708–15.

    Article  PubMed  CAS  Google Scholar 

  46. Auletta FJ, Kamps DL, Pories S, Bissett J, Gibson M. An intracorpus luteum site for the luteolytic action of PGF2α in the rhesus monkey. Prostaglandins 1984; 27:285–98.

    Article  PubMed  CAS  Google Scholar 

  47. Auletta FJ, Paradis DK, Wesley M, Duby RT. Oxytocin is luteolytic in the rhesus monkey (Macaca mulatta). J Reprod Fertil 1984; 72:401–6.

    Article  PubMed  CAS  Google Scholar 

  48. Birnbaumer L, Kirchick HJ. Regulation of gonadotropic action: the molecular mechanisms of gonadotropin-induced activation of ovarian adenylyl cyclases. In: Greenwald G, Terranova P, eds. Factors regulating ovarian function. New York: Raven Press, 1983:287–310.

    Google Scholar 

  49. Ottobre JS, Stouffer RL. Receptors for chorionic gonadotropin in the corpus luteum of the rhesus monkey during simulated early pregnancy: lack of down-regulation. Endocrinology 1986; 1594–1602.

    Google Scholar 

  50. VandeVoort C, Molskness T, Stouffer R. Adenylate cyclase in the primate corpus luteum during CG treatment simulating early pregnancy: homologous (gonadotropin) versus heterologous (prostaglandin) desensitization [Abstract]. Abstract 4 at the Sixth Ovarian Workshop. Ithaca, NY July 14–15, 1986.

    Google Scholar 

  51. Stouffer RL, Bennett LA, Hodgen GD. Estrogen production by luteal cells isolated from rhesus monkeys during the menstrual cycle: correlation with spontaneous luteolysis. Endocrinology 1980; 106:519–25.

    Article  PubMed  CAS  Google Scholar 

  52. Clark MR, Kawai Y, Davis JS, LeMaire WJ. Ovarian protein kinases. In: Toft DO, Ryan RJ, eds. Proceedings of the Fifth Ovarian Workshop. Champaign: Ovarian Workshops, 1985:383–401.

    Google Scholar 

  53. Davis JS, West LA, Weakland LL, Farese RV. hCG activates the inositol 1,4,5-triphosphate-Ca+2 intracellular signalling system in bovine luteal cells. FEBS Lett 1986; 208:287–91.

    Article  PubMed  CAS  Google Scholar 

  54. Hansel W, Dowd JP. New concepts of the control of corpus luteum function. J Reprod Fertil 1986; 78:755–68.

    Article  PubMed  CAS  Google Scholar 

  55. diZerega GS, Hodgen GD. Changing functional status of the monkey corpus luteum. Biol Reprod 1980; 23:253–63.

    Article  PubMed  CAS  Google Scholar 

  56. Schwall RH, Gamboni F, Mayan MH, Niswender GD. Changes in the distribution of sizes of ovine luteal cells during the estrous cycle. Biol Reprod 1986; 34:911–19.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Reproductive Biology and Behavior, Oregon Regional Primate Research Center, Beaverton, Oregon, USA

    Richard L. Stouffer & Catherine A. VandeVoort

  2. Department of Dairy Science, Ohio State University, Columbus, Ohio, USA

    Joseph S. Ottobre

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  1. Richard L. Stouffer
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  2. Joseph S. Ottobre
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  3. Catherine A. VandeVoort
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Editors and Affiliations

  1. Oregon Regional Primate Research Center, Beaverton, Oregon, USA

    Richard L. Stouffer

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© 1987 Plenum Press, New York

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Stouffer, R.L., Ottobre, J.S., VandeVoort, C.A. (1987). Regulation of the Primate Corpus Luteum During Early Pregnancy. In: Stouffer, R.L. (eds) The Primate Ovary. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9513-7_14

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  • DOI: https://doi.org/10.1007/978-1-4615-9513-7_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9515-1

  • Online ISBN: 978-1-4615-9513-7

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