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Oxygen Transport to Tissue X pp 69–75Cite as

Oxygen Delivery to Tissue: Calculation of Oxygen Gradients in the Cardiac Cell

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 222))

Abstract

In this study, a two dimensional mathematical model of a cross section of a single heart muscle cell 30.0 u in diameter, was constructed from which one would be able to calculate the rate of oxygen delivery from the capillary blood supply to the mitochondria by passive oxygen diffusion, myoglobin facilitation of oxygen delivery, and subsequent utilization of oxygen by cytochrome oxidase. From such calculations, the conditions under which the two hemoprotein indicators, myoglobin and cytochrome oxidase, behave in a coherent manner, as observed by Tamura and his colleagues (1978), could be established and the loci of oxygen gradients identified.

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References

  • Chance, B., Chance, E.M. et al., 1987, On the Location of Steep Oxygen Gradients in Rapidly Respiring Tissues, Proc. Natl. Acad. Sci. USA in preparation.

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  • Chance, E.M., Curtis, A.R., Jones, I.P. and Kirby, C.R., 1977, FACSIMILE: A Computer Program for Flow and Chemistry Simulation, and General Initial Value Problems, A.E.R.E. Report No. R8775, H.M. Stationary Office, London.

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  • Curtis, A.R. (1983) An Introduction to the FACSIMILIE Program, AERE Rpt. R-3134, H.M. Stationary Office, London.

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  • Hess, B., Chance, E.M., Curtis, A.R. and Boiteux, A., 1981, in “Complex Dynamic Structures, Snergetics,” Vial, C. and Pacault, A., Eds. Springer Verlag, Berlin, 172–179.

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  • Tamura, M., Oshino, N., Chance, B and Silver, I.A., 1978, Optical Measurements of Intracellular Oxygen Concentration of Rat Heart in vitro. Arch. Biochem. Biophys. 191, 8–82.

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Author information

Authors and Affiliations

  1. Biochemistry Dept., University College London, London, WC1E 6BT, UK

    E. M. Chance

  2. Biochemistry/Biophysics Department, University of Pennsylvania, Phila., PA, 19104, USA

    Britton Chance

  3. Institute for Structural and Functional Studies, University City Science Center, Phila., PA, 19104, USA

    Britton Chance

Authors
  1. E. M. Chance
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  2. Britton Chance
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Editor information

Editors and Affiliations

  1. Nishimaruyama Hospital, Sapporo, Japan

    Masaji Mochizuki

  2. The University of Rochester, Rochester, New York, USA

    Carl R. Honig

  3. Hokkaido University, Sapporo, Japan

    Tomiyasu Koyama

  4. Northwestern University, Evanston, Illinois, USA

    Thomas K. Goldstick

  5. California Polytechnic State University, San Luis Obispo, California, USA

    Duane F. Bruley

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© 1988 Plenum Press, New York

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Chance, E.M., Chance, B. (1988). Oxygen Delivery to Tissue: Calculation of Oxygen Gradients in the Cardiac Cell. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_8

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  • DOI: https://doi.org/10.1007/978-1-4615-9510-6_8

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-9512-0

  • Online ISBN: 978-1-4615-9510-6

  • eBook Packages: Springer Book Archive

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