Abstract
Oxygen transport has traditionally been approached as a specialized subject with little connection to the large amount of data on transport of other substances, equally essential for steady-state metabolism. Heuristically, there is no reason to expect a major difference but measurements of tissue PO2 with oxygen electrodes in organs with high oxygen consumptions have yielded data which are incompatible with the classical Krogh-cylinder model of capillary-tissue oxygen transport. A number of alternative models, including diffusional shunting and flow heterogeneity, have been developed on the assumption that oxygen transport is a special case, with little or no consideration of the overall, nature of organ transport as reflected in the transport of other substances equally essential for metabolism. As we shall show, when examined in this light, oxygen transport is not essentially different from that of other substances. With the understanding afforded by this approach and recent developments based on it, future investigational effort can now be profitably directed at more complex problems, such as the role of impaired oxygen transport in certain pathological states of vital organs.
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© 1988 Plenum Press, New York
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Rose, C.P., Goresky, C.A., Bach, G.G., Bassingthwaighte, J.B., Little, S. (1988). In Vivo Comparison of Non-Gaseous Metabolite and Oxygen Transport in the Heart. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_5
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DOI: https://doi.org/10.1007/978-1-4615-9510-6_5
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