Abstract
The presence of chronic hypoxia in peripheral tissue in patients with chronic obstructive pulmonary disease (COPD) is one of the major factors leading to a poor prognosis (Kawakami et al., 1983) If hemoglobin-oxygen affinity can be reduced by pharmacological agents, oxygen delivery to the tissues should be improved in mild hypoxemia. We examined the effects of three agents on hemoglobin-oxygen affinity in vivo and in vitro. The first is pentoxifylline which is a xanthine derivative and has the effect of improving capillary circulation’ and increasing intracellular ATP (Ohshima and Sato, 1981; Stefanovich, 1975). The second was coenzyme Q10 (CoQ10) which improves oxygen utilization in ischemic heart muscles (Mochizuki et al., 1980). The third was calcium hopantenate which increases glucose utilization in brain tissues (Tamura et al., 1986).
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References
Kawakami, Y., Kishi, F., Yamamoto, H., Miyamoto, K., 1983, Relation of oxygen delivery, mixed venous oxygenation, and pulmonary hemodynamics to prognosis in chronic obstructive pulmonary disease. N Engl J Med., 308:1045.
Mochizuki, S., Feuvray, D., Ishikawa, S., Saso, F., Yoshiwara, T., Ozasa, H., Shimada, T., Saito, N., Abe, M and Neeley, J.R., 1980, Energy metabolism and funktion during ischemia and with reperfusion in rat hearts: Effects of substrates, hormone and coenzyme Q10, in: “Biomedical and Clinical Aspects of Coenzyme Q, Vol 2,” p.377, Yamamura, Y., Folkers, K and Ito, Y.,ed., Elsevier/North-Holland Biomedical Press,
Oski, F.A., Millar, L.D., Delivoria-Papadopoulous, M., Manchester, J.H. and Scheiburne, J.C., 1972, Oxygen affinity in red cells, Changes induced in vivo by propranolol, Science, 175:1372.
Pendelton, P.G., Newman, D.J., Sherman, S.S., Bran, E.G. and Maya, W.E., 1972, Effect of propranolol upon the hemoglobin-oxygen dissociation curve, J Pharmacol Exp Ther., 180:647.
Schrumpf, J.D., Sheps, D.S., Wolfson, S., Aronson, A.L., Cohen, L.S., 1977, Altered hemoglobin-oxygen affinity with long-term proranolol therapy in patients with coronary artery disease, Am J Cardiol., 40:76.
Soliman, M.H., O’Neal, K. and Waxman, K., 1987, Pentoxifylline improves tissue oxygenation following anesthesia and operation, Crit Care Med., 15:93.
Stefanovich, V., 1975, Beeinflussung des ATP-Gehaltes der Erythrozyten durch Pentoxifyllin, Med Welt., 26:1882.
Tamura, J., Hashimoto, K., and Kuriyama, K., 1986. Effect of calcium hopantenate on energy metabolism in the experimental ischemic brain (in Japanese). Folia Pharmacol japon., 88:26p.
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© 1988 Plenum Press, New York
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Kishi, F., Nishiura, Y., Kamada, A., Kawakami, Y. (1988). Pharmacological Effects on Hemoglobin-Oxygen Affinity in Vitro and in Patients with Chronic Obstructive Pulmonary Disease. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_40
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DOI: https://doi.org/10.1007/978-1-4615-9510-6_40
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