Abstract
Oxygen flux to respiring tissue depends upon the oxygen diffusion gradient between blood in the microvascular network and sites of oxygen utilization. Current knowledge of how this gradient is regulated is quite incomplete. The magnitude of the gradient is determined by a number of morphological and functional parameters, one of which is blood oxygen affinity. Experiments examining control of oxygen delivery have traditionally made use of induced changes in parameters determining systemic oxygen transport (FIO2, [Hb], and/or flow), with secondary effects on the pattern of PO2 values along the capillary. Changes in blood oxygen affinity, by contrast, allow one to observe effects of a change in PO2 downstream in the capillary while PO2 upstream and oxygen transport (CaO2 x flow) are not primarily affected.
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© 1988 Plenum Press, New York
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Woodson, R.D. (1988). Evidence that Changes in Blood Oxygen Affinity Modulate Oxygen Delivery: Implications for Control of Tissue PO2 Gradients. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_36
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DOI: https://doi.org/10.1007/978-1-4615-9510-6_36
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