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A Graphical Analysis of the Influence of Red Cell Transit Time, Carrier-Free Layer Thickness, and Intracellular PO2 on Blood-Tissue O2 Transport

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Oxygen Transport to Tissue X

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 222))

Abstract

This paper relates spectroscopic determinations of myoglobin (Mb) saturation and PO2 in individual myocytes (Gayeski and Honig, 1986) to a mathematical model of O2 transport (Federspiel, 1983). A graphical analysis of model results is used to illustrate interactions among the main determinants of O2 transport between hemoglobin (Hb) and cytochrome. The results of the analysis are summarized in a plot called the O2 release curve. The results are qualitatively applicable to normal and pathophysiology, and to Mb-free tissues.

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Author information

Authors and Affiliations

  1. School of Medicine, The University of Rochester, 601 Elmwood Avenue, Rochester, New York, 14642, USA

    T. E. J. Gayeski, W. J. Federspiel & C. R. Honig

  2. The Biomechanics Institute, Boston, Massachusetts, 02215, USA

    T. E. J. Gayeski, W. J. Federspiel & C. R. Honig

Authors
  1. T. E. J. Gayeski
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  2. W. J. Federspiel
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  3. C. R. Honig
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Editor information

Editors and Affiliations

  1. Nishimaruyama Hospital, Sapporo, Japan

    Masaji Mochizuki

  2. The University of Rochester, Rochester, New York, USA

    Carl R. Honig

  3. Hokkaido University, Sapporo, Japan

    Tomiyasu Koyama

  4. Northwestern University, Evanston, Illinois, USA

    Thomas K. Goldstick

  5. California Polytechnic State University, San Luis Obispo, California, USA

    Duane F. Bruley

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© 1988 Plenum Press, New York

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Gayeski, T.E.J., Federspiel, W.J., Honig, C.R. (1988). A Graphical Analysis of the Influence of Red Cell Transit Time, Carrier-Free Layer Thickness, and Intracellular PO2 on Blood-Tissue O2 Transport. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_3

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  • DOI: https://doi.org/10.1007/978-1-4615-9510-6_3

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4615-9512-0

  • Online ISBN: 978-1-4615-9510-6

  • eBook Packages: Springer Book Archive

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