Abstract
Non invasive infrared spectroscopy is a well established technique for monitoring changes in the oxygenation status of tissues (1). The technique has in particular been successfully employed to monitor changes in cerebral blood and tissue oxygenation by observing the absorption of haemoglobin and cytochrome aa3 respectively. Because of the highly light scattering nature of the tissues studied, it has normally not been possible to quantitate the observed changes.
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References
F.F. Jobsis, Noninvasive, infrared monitoring of cerebral and myocardial oxygen deficiency and circulatory parameters, Science, 198:1264–1267 (1977).
J.S. Wyatt, M. Cope, D.T. Delpy, S. Wray, E.O.R. Reynolds, Quantitation of cerebral oxygenation and haemodynamics in sick newborn infants by near infra red spectrophotometry, Lancet, 8515:1063–1066 (1986).
M. Cope, D.T. Delpy, A system for long term cerebral blood and tissue oxygenation measurement on newborn infants by near infra red transillumination, in: “Optical monitoring of metabolism in vivo”, F.F. Jobsis, ed., Plenum Press (in press).
S. Wray, M. Cope, D.T. Delpy, J.S. Wyatt, E.O.R. Reynolds, Characterisation of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the noninvasive monitoring of cerebral oxygenation, Biochem. Biophys. Acta (submitted).
L.O. Svaasand, R. Ellingsen, Optical properties of human brain, Photochem. & Photobiol., 38:3:293–299 (1983).
L.O. Svaasand, R. Ellingsen, Optical penetration in human intracranial tumours, Photochem. & Photobiol., 41:1:73–76 (1985).
P. van der Zee, D.T. Delpy, Simulation of the point spread function for light in tissue by a Monte Carlo method, in: “Oxygen transport to tissue”, vol. IX, I.A. Silver, ed., Plenum Press, New York (1987).
G. Ladurner, E. Zilkha, L.D. Iliff, G.H. Du Boulay, J. Marshall, Measurement of regional cerebral blood volume by computerised axial tomography, J. Neurol., Neurosurg. & Psychiatry, 39:152–158 (1976).
F. Sakai, K. Nakazawa, Y. Tazaki, K. Ishii, H. Hiro, H. Igarishi, T. Kanda, Regional cerebral blood volume and haematocrit measured in normal human volunteers by single photon emission computed tomography, J. Cereb. Blood Flow & Met., 5:207–213 (1985).
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© 1988 Plenum Press, New York
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Cope, M., Delpy, D.T., Reynolds, E.O.R., Wray, S., Wyatt, J., van der Zee, P. (1988). Methods of Quantitating Cerebral Near Infrared Spectroscopy Data. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_21
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DOI: https://doi.org/10.1007/978-1-4615-9510-6_21
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