Abstract
Theoretical modeling of oxygen delivery to tissue provides a means to obtain information about oxygen concentration fields in tissue at the scale of individual capillaries. Such information is difficult or impossible to obtain with available experimental techniques. Theoretical models can provide insights into the relationship between perfusion and metabolic demand in tissue, and also contribute to the understanding of metabolic mechanisms of blood flow regulation. The value of theoretical analyses was recognized in the classic work of Krogh (1918) on oxygen diffusion from parallel arrays of capillaries, and since then most models of oxygen delivery to tissue have been modifications and extensions of the Krogh model (Middleman, 1972). Generally, these models have retained the assumption that each point in the tissue receives oxygen only from the nearest capillary. However, this assumption was relaxed, for the case of multiple parallel capillaries, in studies by Popel (1978, 1980), Salathe (1982) and Klitzman et al (1983).
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© 1988 Plenum Press, New York
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Secomb, T.W., Hsu, R. (1988). Analysis of Oxygen Delivery to Tissue by Microvascular Networks. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_11
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DOI: https://doi.org/10.1007/978-1-4615-9510-6_11
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