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In Situ Detection of GAD mRNA in Mouse Brain

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In Situ Hybridization in Brain

Abstract

The enzyme glutamic acid decarboxylase (GAD, E.C. 4.1.1.15) is responsible for the biosynthesis of GABA, one of the most abundant inhibitory neurotransmitters in the vertebrate brain. In humans, pathophysiology involving GABA inhibitory systems can lead to movement disorders, seizures, and mental dysfunction (1–3). Detection of GAD mRNA by in situ hybridization can allow new approaches to the study of the regulation of these important systems.

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Author information

Authors and Affiliations

  1. Department of Biology, Mental Retardation Research Center, Los Angeles, CA, 90024, USA

    Carol W. Wuenschell, Robin S. Fisher, Niranjala J. K. Tillakaratne & Allen J. Tobin

  2. Department of Anatomy, Molecular Biology Institute, Los Angeles, CA, 90024, USA

    Carol W. Wuenschell, Robin S. Fisher, Niranjala J. K. Tillakaratne & Allen J. Tobin

  3. Department of Psychiatry, Molecular Biology Institute, Los Angeles, CA, 90024, USA

    Carol W. Wuenschell, Robin S. Fisher, Niranjala J. K. Tillakaratne & Allen J. Tobin

  4. Brain Research Institute, University of California, Los Angeles, CA, 90024, USA

    Carol W. Wuenschell, Robin S. Fisher, Niranjala J. K. Tillakaratne & Allen J. Tobin

Authors
  1. Carol W. Wuenschell
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  2. Robin S. Fisher
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  3. Niranjala J. K. Tillakaratne
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  4. Allen J. Tobin
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Editor information

Editors and Affiliations

  1. Department of Neurology and Howard Hughes Medical Institute, USA

    George R. Uhl M.D., Ph.D.

  2. Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

    George R. Uhl M.D., Ph.D.

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© 1986 Plenum Press, New York

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Wuenschell, C.W., Fisher, R.S., Tillakaratne, N.J.K., Tobin, A.J. (1986). In Situ Detection of GAD mRNA in Mouse Brain. In: Uhl, G.R. (eds) In Situ Hybridization in Brain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9486-4_8

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  • DOI: https://doi.org/10.1007/978-1-4615-9486-4_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9488-8

  • Online ISBN: 978-1-4615-9486-4

  • eBook Packages: Springer Book Archive

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