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Molecular Approaches to Human Neurological Diseases and Their Animal Models

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In Situ Hybridization in Brain

Abstract

In situ hybridization with labeled probes will have widespread applicability for investigations of neuropathological processes occurring in humans and animals. At this stage in the development of this approach, it is important to determine the kinds of questions that can be usefully examined with this technique, recognizing that in situ hybridization needs to be complemented by other methods, e.g., RNA blots, radioimmunoassays, and immunocytochemistry.

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Author information

Authors and Affiliations

  1. Neuropathology Laboratory, Neuromuscular Laboratory, Division of Comparative Medicine, Department of Pathology, Department of Neurology, Department of Neuroscience, and Department of Ophthalmology, Johns Hopkins Medical Institutions, Baltimore, MD, 21205, USA

    Donald L. Price, Paul N. Hoffman, Richard J. Altschuler, Edward H. M. Koo, Peter J. Whitehouse, John W. Griffin, Cheryl A. Kitt, Linda C. Cork, Richard E. Powers, Lary C. Walker, Errol B. DeSouza & W. Scott Young III

  2. Laboratory of Cell Biology, National Institutes of Mental Health, Bethesda, MD, 20205, USA

    Donald L. Price, Paul N. Hoffman, Richard J. Altschuler, Edward H. M. Koo, Peter J. Whitehouse, John W. Griffin, Cheryl A. Kitt, Linda C. Cork, Richard E. Powers, Lary C. Walker, Errol B. DeSouza & W. Scott Young III

  3. National Institute of Drug Abuse and Alcohol, Baltimore, MD, 21202, USA

    Donald L. Price, Paul N. Hoffman, Richard J. Altschuler, Edward H. M. Koo, Peter J. Whitehouse, John W. Griffin, Cheryl A. Kitt, Linda C. Cork, Richard E. Powers, Lary C. Walker, Errol B. DeSouza & W. Scott Young III

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  1. Donald L. Price
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Editor information

Editors and Affiliations

  1. Department of Neurology and Howard Hughes Medical Institute, USA

    George R. Uhl M.D., Ph.D.

  2. Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

    George R. Uhl M.D., Ph.D.

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© 1986 Plenum Press, New York

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Price, D.L. et al. (1986). Molecular Approaches to Human Neurological Diseases and Their Animal Models. In: Uhl, G.R. (eds) In Situ Hybridization in Brain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9486-4_10

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  • DOI: https://doi.org/10.1007/978-1-4615-9486-4_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9488-8

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