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Central and Peripheral Mechanisms of Cardiovascular Regulation pp 59–81Cite as

Mechanisms Involved in the Actions of Stimulant Drugs on Vascular Smooth Muscle

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Part of the book series: NATO ASI Series ((NSSA,volume 109))

Abstract

Smooth muscle tissues in the mammalian body carry out a wide variety of physiological functions. In each organ the smooth muscle is organized to provide tension development, or relaxation of existing tension, in response to varied stimuli reaching it from both local and distant parts of the body. The stimuli which reach it are of two main types — blood borne or local hormones and neurotransmitter substances. The smooth muscle in a particular organ is generally endowed with a wide variety of receptors which can recognize and respond to these hormones and neurotransmitters. The complement of receptors possessed by a particular smooth muscle to a large extent determine its responsiveness to chemical signals from other cells of the body. A second important factor in determining this responsiveness is the type of electromechanical coupling exhibited by the constituent smooth muscles of the tissue. In different tissues this takes a bewildering variety of forms. However, a simple and important division is between those smooth muscle cells which readily generate and propagate action potentials and those which do not. Where action potentials occur in smooth muscle cells they are the main determinant of tension generation by smooth muscle tissues — although not necessarily the only one.

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Authors and Affiliations

  1. Department of Pharmacology, St. George’s Hospital Medical School, London, SW17 ORE, UK

    Thomas B. Bolton

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  1. Thomas B. Bolton
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Editors and Affiliations

  1. Wadsworth Center for Laboratories and Research, Albany, New York, USA

    A. Magro

  2. University of Porto, Porto, Portugal

    W. Osswald

  3. Cornell University Medical College, New York, New York, USA

    D. Reis

  4. Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

    P. Vanhoutte

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© 1986 Plenum Press, New York

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Bolton, T.B. (1986). Mechanisms Involved in the Actions of Stimulant Drugs on Vascular Smooth Muscle. In: Magro, A., Osswald, W., Reis, D., Vanhoutte, P. (eds) Central and Peripheral Mechanisms of Cardiovascular Regulation. NATO ASI Series, vol 109. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9471-0_3

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  • DOI: https://doi.org/10.1007/978-1-4615-9471-0_3

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